Publications

Hoogenboom, B. W., Hough, L. E., Lemke, E. A., Lim, R. Y. H., Onck, P. R. and Zilman, A. (2021) “Physics of the nuclear pore complex: Theory, modeling and experiment”, Physics reports, p. ahead of print. doi: 10.1016/j.physrep.2021.03.003.   
Kalita, J., Kapinos, L. E. and Lim, R. Y. H. (2021) “On the asymmetric partitioning of nucleocytoplasmic transport - recent insights and open questions”, Journal of cell science, 134, p. jcs240382. doi: 10.1242/jcs.240382.   
Sharma, D., Lim, R. Y. H., Pfohl, T. and Ekinci, Y. (2021) “Optimization of Nanofluidic Devices for Geometry-Induced Electrostatic Trapping”, Particle & particle systems characterization, p. 2000275.   
Santos, J. C., Boucher, D., Schneider, L. K., Demarco, B., Dilucca, M., Shkarina, K., Heilig, R., Chen, K. W., Lim, R. Y. H. and Broz, P. (2020) “Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria”, Nature Communications. Nature Publishing Group, 11(1), p. 3276. doi: 10.1038/s41467-020-16889-z.   edoc | Open Access
Avsar, S. Y., Kapinos, L. E., Schoenenberger, C.-A., Schertler, G. F. X., Muhle, J., Meger, B., Lim, R. Y. H., Ostermaier, M. K., Lesca, E. and Palivan, C. G. (2020) “Immobilization of arrestin-3 on different biosensor platforms for evaluating GPCR binding”, Physical Chemistry Chemical Physics. Royal Society of Chemistry, 22(41), pp. 24086–24096. doi: 10.1039/d0cp01464h.   edoc | Open Access
Zelmer, C., Zweifel, L. P., Kapinos, L. E., Craciun, I., Güven, Z. P., Palivan, C. G. and Lim, R. Y. H. (2020) “Organelle-specific targeting of polymersomes into the cell nucleus”, Proceedings of the National Academy of Sciences of the United States of America, p. aheadofrint. doi: 10.1073/pnas.1916395117.   
Barbato, S., Kapinos, L. E., Rencurel, C. and Lim, R. Y. H. (2020) “Karyopherin enrichment at the nuclear pore complex attenuates Ran permeability”, Journal of cell science, p. aheadofrint. doi: 10.1242/jcs.238121.   
Kassianidou, E., Kalita, J. and Lim, R. Y. H. (2019) “The role of nucleocytoplasmic transport in mechanotransduction”, Experimental cell research. Elsevier, 377(1-2), pp. 86–93. doi: 10.1016/j.yexcr.2019.02.009.   edoc
Panatala, R., Barbato, S., Kozai, T., Luo, J., Kapinos, L. E. and Lim, R. Y. H. (2019) “Nuclear Pore Membrane Proteins Self-Assemble into Nanopores ”, Biochemistry. American Chemical Society, 58(6), pp. 484–488. doi: 10.1021/acs.biochem.8b01179.   edoc
Eftekharzadeh, B., Daigle, J. G., Kapinos, L. E., Coyne, A., Schiantarelli, J., Carlomagno, Y., Cook, C., Miller, S. J., Dujardin, S., Amaral, A. S., Grima, J. C., Bennet, R. E., Tepper, K., DeTure, M., Vanderburgh, C. R., Corjuc, B. T., Devos, S. L., Gonzalez, J. A., Chew, J., Vidensky, S., Gage, F. H., Mertens, J., Troncoso, J., Mandelkow, E., Salvatella, X., Lim, R. Y. H., Petrucelli, L., Wegmann, S., Rothstein, J. D. and Hyman, B. T. (2018) “Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease”, Neuron. Cell Press, 99(5), pp. 925–940.e7. doi: 10.1016/j.neuron.2018.07.039.   edoc
Emilsson, G., Sakiyama, Y., Malekian, B., Xiong, K., Adali-Kaya, Z., Lim, R. Y. H. and Dahlin, A. B. (2018) “Gating Protein Transport in Solid State Nanopores by Single Molecule Recognition”, ACS Central Science. American Chemical Society, 4(8), pp. 1007–1014. doi: 10.1021/acscentsci.8b00268.   edoc
Malekian, B., Schoch, R. L., Robson, T., Ferrand-Drake del Castillo, G., Xiong, K., Emilsson, G., Kapinos, L. E., Lim, R. Y. H. and Dahlin, A. B. (2018) “Detecting Selective Protein Binding inside Plasmonic Nanopores: Towards a Mimic of the Nuclear Pore Complex”, Frontiers in Chemistry. Edited by E. Reimhult. Frontiers Research Foundation, 6, p. 637. doi: 10.3389/fchem.2018.00637.   edoc
Zanetti-Dällenbach, R., Plodinec, M., Oertle, P., Redling, K., Obermann, E. C., Lim, R. Y. H. and Schoenenberger, C.-A. (2018) “Length Scale Matters: Real-Time Elastography versus Nanomechanical Profiling by Atomic Force Microscopy for the Diagnosis of Breast Lesions”, BioMed research international. Hindawi, 2018, p. 3840597. doi: 10.1155/2018/3840597.   edoc
Ganier, O., Schnerch, D., Oertle, P., Lim, R. Y. H., Plodinec, M. and Nigg, E. A. (2018) “Structural centrosome aberrations promote non-cell-autonomous invasiveness”, The EMBO journal, p. e98576. doi: 10.15252/embj.201798576.   edoc | Open Access
Emilsson, G., Xiong, K., Sakiyama, Y., Malekian, B., Gagnér, V. A., Schoch, R. L., Lim, R. Y. H. and Dahlin, A. B. (2018) “Polymer brushes in solid-state nanopores form an impenetrable entropic barrier for proteins”, Nanoscale. Royal Society of Chemistry, (10), pp. 4663–4669. doi: 10.1039/c7nr09432a.   edoc | Open Access
Schoch, R. L., Emilsson, G., Dahlin, A. B. and Lim, R. Y. H. (2017) “Protein exclusion is preserved by temperature sensitive PEG brushes”, Polymer, 132, pp. 362–367. doi: 10.1016/j.polymer.2017.10.063.   edoc
Luo, W., Ruba, A., Takao, D., Zweifel, L. P., Lim, R. Y. H., Verhey, K. J. and Yang, W. (2017) “Axonemal Lumen Dominates Cytosolic Protein Diffusion inside the Primary Cilium”, Scientific Reports. Nature Publishing Group, 7, p. 15793. doi: 10.1038/s41598-017-16103-z.   edoc | Open Access
Emilsson, G., Schoch, R. L., Oertle, P., Xiong, K., Lim, R. Y. H. and Dahlin, A. B. (2017) “Surface plasmon resonance methodology for monitoring polymerization kinetics and morphology changes of brushes - evaluated with poly(N-isopropylacrylamide)”, Applied Surface Science. Elsevier, 396, pp. 384–392. doi: 10.1016/j.apsusc.2016.10.165.   edoc
Sakiyama, Y., Panatala, R. and Lim, R. Y. H. (2017) “Structural dynamics of the nuclear pore complex”, Seminars in Cell and Developmental Biology. Elsevier, 68, pp. 27–33. doi: 10.1016/j.semcdb.2017.05.021.   edoc
Benning, F. M. C., Sakiyama, Y., Mazur, A., Bukhari, H. S. T., Lim, R. Y. H. and Maier, T. (2017) “High-Speed Atomic Force Microscopy Visualization of the Dynamics of the Multienzyme Fatty Acid Synthase”, ACS Nano. American Chemical Society, 11(11), pp. 10852–10859. doi: 10.1021/acsnano.7b04216.   edoc
Kapinos, L. E., Huang, B., Rencurel, C. and Lim, R. Y. H. (2017) “Karyopherins regulate nuclear pore complex barrier and transport function”, Journal of Cell Biology. Rockefeller University Press, 216(11), pp. 3609–3624. doi: 10.1083/jcb.201702092.   edoc | Open Access
Vovk, A., Gu, C., Opferman, M. G., Kapinos, L. E., Lim, R. Y. H., Coalson, R. D., Jasnow, D. and Zilman, A. (2016) “Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex”, eLife. eLife Sciences Publications , 5, p. e10785. doi: 10.7554/eLife.10785.001.   edoc | Open Access
Zweifel, L. P., Shorubalko, I. and Lim, R. Y. H. (2016) “Helium scanning transmission ion microscopy and electrical characterization of glass nanocapillaries with reproducible tip geometries”, ACS nano. American Chemical Society, 10(2), pp. 1918–1925. doi: 10.1021/acsnano.5b05754.   edoc
Sakiyama, Y., Mazur, A., Kapinos, L. E. and Lim, R. Y. H. (2016) “Spatiotemporal dynamics of the nuclear pore complex transport barrier resolved by high-speed atomic force microscopy”, Nature Nanotechnology. Nature Publishing Group, (11), pp. 719–723. doi: 10.1038/NNANO.2016.62.   edoc
Vujica, S., Zelmer, C., Panatala, R. and Lim, R. Y. H. (2016) “Nucleocytoplasmic Transport: A Paradigm for Molecular Logistics in Artificial Systems”, Chimia. Schweizerische Chemische Gesellschaft, 70(6), pp. 413–417. doi: 10.2533/chimia.2016.413.   edoc | Open Access
Lim, R. Y. H., Huang, B. and Kapinos, L. E. (2015) “How to operate a nuclear pore complex by Kap-centric control”, Nucleus (Austin, Tex.). Taylor & Francis, 6(5), pp. 366–372. doi: 10.1080/19491034.2015.1090061.   edoc
Plodinec, M. and Lim, R. Y. H. (2015) “Nanomechanical characterization of living mammary tissues by atomic force microscopy”, Methods in Molecular Biology. Humana Press, 1293, pp. 231–246. doi: 10.1007/978-1-4939-2519-3_14.   edoc
Emilsson, G., Schoch, R. L., Feuz, L., Höök, F., Lim, R. Y. H. and Dahlin, A. B. (2015) “Strongly Stretched Protein Resistant Poly(ethylene glycol) Brushes Prepared by Grafting-To”, ACS applied materials & interfaces. American Chemical Society, Vol. 7, H. 14, pp. 7505–7515. doi: 10.1021/acsami.5b01590.   edoc
Wagner, R. S., Kapinos, L. E., Marshall, N. J., Stewart, M. and Lim, R. Y. H. (2015) “Promiscuous Binding of Karyopherinβ1 Modulates FG Nucleoporin Barrier Function and Expedites NTF2 Transport Kinetics”, Biophysical journal. Biophysical Society, 108(4), pp. 918–927. doi: 10.1016/j.bpj.2014.12.041.   edoc | Open Access
Fuxreiter, M., Tóth-Petróczy, A., Kraut, D. A., Matouschek, A. T., Lim, R. Y. H., Xue, B., Kurgan, L. and Uversky, V. N. (2014) “Disordered Proteinaceous Machines”, Chemical reviews. Williams Wilkins, Vol. 114, H. 13 , S. 6806–6843. doi: 10.1021/cr4007329.   edoc
Schleicher, K. D., Dettmer, S. D., Kapinos, L. E., Pagliara, S., Keyser, U. F., Jeney, S. and Lim, R. Y. H. (2014) “Selective transport control on molecular velcro made from intrinsically disordered proteins”, Nature nanotechnology. Nature Publishing Group, Vol. 9 H. 7 , S. 525–530. doi: 10.1038/NNANO.2014.103.   edoc
Kapinos, L. E., Schoch, R. L., Wagner, R. S., Schleicher, K. D. and Lim, R. Y. H. (2014) “Karyopherin-centric control of nuclear pores based on molecular occupancy and kinetic analysis of multivalent binding with FG nucleoporins”, Biophysical journal. Biophysical Society, Vol. 106, H. 8, pp. 1751–1762. doi: 10.1016/j.bpj.2014.02.021.   edoc
Halfter, W., Monnier, C., Mueller, D., Oertle, P., Uechi, G., Balasubramani, M., Safi, F., Lim, R., Loparic, M. and Henrich, P. B. (2013) “The Bi-Functional Organization of Human Basement Membranes”, PLoS ONE. Public Library of Science, 8 (7), p. e67660. doi: 10.1371/journal.pone.0067660.   edoc | Open Access
Schoch, R. L. and Lim, R. Y. H. (2013) “Non-interacting molecules as innate structural probes in surface plasmon resonance”, Langmuir. American Chemical Society, Vol. 29, H. 12, pp. 4068–4076. doi: 10.1021/la3049289.   edoc
Hyotyla, J. T. and Lim, R. Y. H. (2012) “Atomic force microscopy”, in Supramolecular chemistry. From molecules to nanomaterials. Oxford: Wiley-Blackwell, pp. 659–668. doi: 10.1002/9780470661345.smc043.   edoc
Henrich, P. B., Monnier, C. A., Halfter, W., Haritoglou, C., Strauss, R. W., Lim, R. Y. H. and Loparic, M. (2012) “Nanoscale topographic and biomechanical studies of the human internal limiting membrane”, Investigative ophthalmology & visual science, 53(6), pp. 2561–2570. doi: 10.1167/iovs.11-8502.   edoc | Open Access
Lim, R. Y. H. and Herrmann, H. (2012) “From structural architecture to cellular organization : celebrating the scientific contributions of Ueli Aebi on the occasion of his retirement”, Journal of structural biology. Academic Press, Vol. 177, H. 1, pp. 1–2. doi: 10.1016/j.jsb.2011.12.011.   edoc
Schoch, R. L., Kapinos, L. E. and Lim, R. Y. H. (2012) “Nuclear transport receptor binding avidity triggers a self-healing collapse transition in FG-nucleoporin molecular brushes”, Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 109(42), pp. 16911–16916. doi: 10.1073/pnas.1208440109.   edoc | Open Access
Plodinec, M., Loparic, M., Monnier, C. A., Obermann, E. C., Zanetti-Dallenbach, R., Oertle, P., Hyotyla, J. T., Aebi, U., Bentires-Alj, M., Lim, R. Y. H. and Schoenenberger, C. .-A. (2012) “The nanomechanical signature of breast cancer”, Nature nanotechnology. Nature Publishing Group, Vol. 7, H. 11, pp. 757–765.   edoc
Hyotyla, J. T., Deng, J. and Lim, R. Y. H. (2011) “Synthetic Protein Targeting by the Intrinsic Biorecognition Functionality of Poly(ethylene glycol) Using PEG Antibodies as Biohybrid Molecular Adaptors”, ACS nano. American Chemical Society, Vol. 5, H. 6, pp. 5180–5187. doi: 10.1021/nn201327y.   edoc
Kowalczyk, S. W., Kapinos, L., Blosser, T. R., Magalhaes, T., van Nies, P., Lim, R. Y. H. and Dekker, C. (2011) “Single-molecule transport across an individual biomimetic nuclear pore complex”, Nature Nanotechnology. Nature Publishing Group, Vol. 6, H. 7, pp. 433–438. doi: 10.1038/nnano.2011.88.   edoc
Peleg, O. and Lim, R. Y. H. (2010) “Converging on the function of intrinsically disordered nucleoporins in the nuclear pore complex”, Biological Chemistry. de Gruyter, 391(7), pp. 719–730. doi: 10.1515/bc.2010.092.   edoc | Open Access
Backmann, N., Kappeler, N., Braun, T., Huber, F., Lang, H.-P., Gerber, C. and Lim, R. Y. H. (2010) “Sensing surface PEGylation with microcantilevers”, Beilstein Journal of Nanotechnology. Beilstein-Institut , 1, pp. 3–13. doi: 10.3762/bjnano.1.2.   edoc | Open Access
Lim, R. Y. H. and Deng, J. (2009) “Interaction forces and reversible collapse of a polymer brush-gated nanopore”, ACS nano. American Chemical Society, Vol. 3, no. 10, pp. 2911–2918. doi: 10.1021/nn900152m.   edoc
Elad, N., Maimon, T., Frenkiel-Krispin, D., Lim, R. Y. H. and Medalia, O. (2009) “Structural analysis of the nuclear pore complex by integrated approaches”, Current Opinion in Structural Biology. Current Biology, Vol. 19, H. 2, pp. 226–232. doi: 10.1016/j.sbi.2009.02.009.   edoc
Lim, R. Y. H., Aebi, U. and Fahrenkrog, B. (2008) “Towards reconciling structure and function in the nuclear pore complex”, Histochemistry and cell biology. Springer International, 129(2), pp. 105–116. doi: 10.1007/s00418-007-0371-x.   edoc | Open Access
Lim, R. Y. H. (2007) “Gate-crashing the nuclear pore complex”, Structure: with folding and design. Current Biology, Vol. 15, H. 8, pp. 889–891. doi: 10.1016/j.str.2007.07.005.   edoc
Lim, R. Y. H., Fahrenkrog, B., Koser, J., Schwarz-Herion, K., Deng, J. and Aebi, U. (2007) “Nanomechanical basis of selective gating by the nuclear pore complex”, Science. American Association for the Advancement of Science, Vol. 318, no. 5850, pp. 640–643. doi: 10.1126/science.1145980.   edoc
Lim, R. Y. H., Koser, J., Huang, N. .-P., Schwarz-Herion, K. and Aebi, U. (2007) “Nanomechanical interactions of phenylalanine-glycine nucleoporins studied by single molecule force-volume spectroscopy”, Journal of Structural Biology. Academic Press, Vol. 159, H. 2, pp. 277–289. doi: 10.1016/j.jsb.2007.01.018.   edoc
Lim, R. Y. H., Aebi, U. and Stoffler, D. (2006) “From the trap to the basket : getting to the bottom of the nuclear pore complex”, Chromosoma. Springer, Vol. 115, H. 1, pp. 15–26. doi: 10.1007/s00412-005-0037-1.   edoc
Lim, R. Y. H., Huang, N.-P., Köser, J., Deng, J., Lau, K. H. A., Schwarz-Herion, K., Fahrenkrog, B. and Aebi, U. (2006) “Flexible phenylalanine-glycine nucleoporins as entropic barriers to nucleocytoplasmic transport”, Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 103(25), pp. 9512–9517. doi: 10.1073/pnas.0603521103.   edoc | Open Access
Lim, R. Y. H. and Fahrenkrog, B. (2006) “The nuclear pore complex up close”, Current opinion in cell biology. Elsevier, Vol. 18, H. 3, pp. 342–347. doi: 10.1016/j.ceb.2006.03.006.   edoc
Lim, R. Y. H. and Aebi, U. (2005) “In silico access to the nuclear pore complex”, Structure: with folding and design. Current Biology, Vol. 13, H. 12, pp. 1741–1743. doi: 10.1016/j.str.2005.11.002.   edoc
Lim, R. Y. H. and O’Shea, S. J. (2004) “Discrete solvation layering in confined binary liquids”, Langmuir. American Chemical Society, 20(12), pp. 4916–4919. doi: 10.1021/la036200g.   edoc
Loh, K. P., Xie, X. N., Lim, Y. H., Teo, E. J., Zheng, J. C. and Ando, T. (2002) “Surface oxygenation studies on (100)-oriented diamond using an atom beam source and local anodic oxidation”, Surface Science. Elsevier, 505, pp. 93–114. doi: 10.1016/s0039-6028(02)01103-2.   edoc
Lim, R., Li, S. F. Y. and O’Shea, S. J. (2002) “Solvation forces using sample-modulation atomic force microscopy”, Langmuir. American Chemical Society, 18(16), pp. 6116–6124. doi: 10.1021/la011789+.   edoc
Tripathy, S., Chua, S. J., Ramam, A., Sia, E. K., Pan, J. S., Lim, R., Yu, G. and Shen, Z. X. (2002) “Electronic and vibronic properties of Mg-doped GaN: The influence of etching and annealing”, Journal of Applied Physics. AIP Publishing, 91(5), pp. 3398–3407. doi: 10.1063/1.1446236.   edoc
Lim, R. and O’Shea, S. J. (2002) “Solvation forces in branched molecular liquids”, Physical Review Letters. American Physical Society, 88(24), p. 246101. doi: 10.1103/PhysRevLett.88.246101.   edoc
Xie, X. N., Lim, R., Li, J., Li, S. F. Y. and Loh, K. P. (2001) “Atomic hydrogen beam etching of carbon superstructures on 6H-SiC(0001) studied by reflection high-energy electron diffraction”, Diamond and Related Materials. Elsevier, 10(3-7), pp. 1218–1223. doi: 10.1016/s0925-9635(00)00398-8.   edoc
Lim, R., Li, J., Li, S. F. Y., Feng, Z. and Valiyaveettil, S. (2000) “The formation of two-dimensional supramolecular chiral lamellae by diamide molecules at the solution/graphite interface: A scanning tunneling microscopy study”, Langmuir. American Chemical Society, 16(17), pp. 7023–7030. doi: 10.1021/la000083x.   edoc