Publications

Benz, F., Huisman, J. S., Bakkeren, E., Herter, J. A., Stadler, T., Ackermann, M., Diard, M., Egli, A., Hall, A. R., Hardt, W.-D. and Bonhoeffer, S. (2020) “Plasmid- and strain-specific factors drive variation in ESBL-plasmid spread in vitro and in vivo”, The ISME journal. Springer nature, p. on-line ahead of print. doi: 10.1038/s41396-020-00819-4.   edoc | Open Access
Bakkeren, E., Diard, M. and Hardt, W.-D. (2020) “Evolutionary causes and consequences of bacterial antibiotic persistence”, Nature reviews. Microbiology. Nature Research , 18(9), pp. 479–490. doi: 10.1038/s41579-020-0378-z.   edoc
Hoces, D., Arnoldini, M., Diard, M., Loverdo, C. and Slack, E. (2020) “Growing, evolving and sticking in a flowing environment: understanding IgA interactions with bacteria in the gut”, Immunology. Wiley, 159(1), pp. 52–62. doi: 10.1111/imm.13156.   edoc
Hausmann, A., Böck, D., Geiser, P., Berthold, D. L., Fattinger, S. A., Furter, M., Bouman, J. A., Barthel-Scherrer, M., Lang, C. M., Bakkeren, E., Kolinko, I., Diard, M., Bumann, D., Slack, E., Regoes, R. R., Pilhofer, M., Sellin, M. E. and Hardt, W.-D. (2020) “Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression”, Mucosal Immunology. Nature, (13), pp. 530–544. doi: 10.1038/s41385-019-0247-0.   edoc | Open Access
Diard, M. ., Bakkeren, E. ., Hoces, D. ., Lentsch, V. ., Arnoldini, M. ., Böhi, F., Schumann-Moor, K. ., Adamcik, J., Piccoli, L., Lanzavecchia, A., Stadtmueller, B. M., Donohue, N. ., van der Woude, M. W. ., Hockenberry, A. ., Viollier, P. H., Falquet, L., Wüthrich, D. ., Bonfiglio, F. ., Egli, A. ., Zandomeneghi, G. ., Mezzenga, R., Holst, O., Meier, B. H., Hardt, W.-D. and Slack, E. (2019) “Rationally designed oral vaccines can set an evolutionary trap for Salmonella Typhimurium”. bioRxiv. doi: 10.1101/824821.   edoc | Open Access
Harms, A. and Diard, M. (2019) “Crowd Controlled-Host Quorum Sensing Drives Phage Decision”, Cell host & microbe. Elsevier, 25(2), pp. 179–181. doi: 10.1016/j.chom.2019.01.016.   edoc
Bakkeren, E., Huisman, J. S., Fattinger, S. A., Hausmann, A., Furter, M., Egli, A., Slack, E., Sellin, M. E., Bonhoeffer, S., Regoes, R. R., Diard, M. and Hardt, W.-D. (2019) “Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut”, Nature, 573(7773), pp. 276–280. doi: 10.1038/s41586-019-1521-8.   edoc
Bansept, F., Schumann-Moor, K., Diard, M., Hardt, W.-D., Slack, E. and Loverdo, C. (2019) “Enchained growth and cluster dislocation: A possible mechanism for microbiota homeostasis”, PLoS computational biology, 15(5), p. e1006986. doi: 10.1371/journal.pcbi.1006986.   edoc
Wotzka, S. Y., Kreuzer, M., Maier, L., Arnoldini, M., Nguyen, B. D., Brachmann, A. O., Berthold, D. L., Zünd, M., Hausmann, A., Bakkeren, E., Hoces, D., Gül, E., Beutler, M., Dolowschiak, T., Zimmermann, M., Fuhrer, T., Moor, K., Sauer, U., Typas, A., Piel, J., Diard, M., Macpherson, A. J., Stecher, B., Sunagawa, S., Slack, E. and Hardt, W.-D. (2019) “Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice”, Nature microbiology, 4(12), pp. 2164–2174. doi: 10.1038/s41564-019-0568-5.   edoc
Diard, M. and Hardt, W.-D. (2017) “Evolution of bacterial virulence”, FEMS Microbiology Reviews, 41(5), pp. 679–697. doi: 10.1093/femsre/fux023.   edoc
Diard, M. and Hardt, W.-D. (2017) “Basic Processes in Salmonella-Host Interactions: Within-Host Evolution and the Transmission of the Virulent Genotype”, Microbiology Spectrum, 5(5), p. epub. doi: 10.1128/microbiolspec.MTBP-0012-2016.   edoc
Diard, M., Bakkeren, E., Cornuault, J. K., Moor, K., Hausmann, A., Sellin, M. E., Loverdo, C., Aertsen, A., Ackermann, M., De Paepe, M., Slack, E. and Hardt, W.-D. (2017) “Inflammation boosts bacteriophage transfer between Salmonella spp”, Science, 355(6330), pp. 1211–1215. doi: 10.1126/science.aaf8451.   edoc
Moor, K., Diard, M., Sellin, M. E., Felmy, B., Wotzka, S. Y., Toska, A., Bakkeren, E., Arnoldini, M., Bansept, F., Co, A. D., Völler, T., Minola, A., Fernandez-Rodriguez, B., Agatic, G., Barbieri, S., Piccoli, L., Casiraghi, C., Corti, D., Lanzavecchia, A., Regoes, R. R., Loverdo, C., Stocker, R., Brumley, D. R., Hardt, W.-D. and Slack, E. (2017) “High-avidity IgA protects the intestine by enchaining growing bacteria”, Nature, 544(7651), pp. 498–502. doi: 10.1038/nature22058.   edoc
Colgan, A. M., Kröger, C., Diard, M., Hardt, W.-D., Puente, J. L., Sivasankaran, S. K., Hokamp, K. and Hinton, J. C. D. (2016) “The Impact of 18 Ancestral and Horizontally-Acquired Regulatory Proteins upon the Transcriptome and sRNA Landscape of Salmonella enterica serovar Typhimurium”, PLoS genetics, 12(8), p. e1006258. doi: 10.1371/journal.pgen.1006258.   edoc
Curkić, I., Schütz, M., Oberhettinger, P., Diard, M., Claassen, M., Linke, D. and Hardt, W.-D. (2016) “Epitope-Tagged Autotransporters as Single-Cell Reporters for Gene Expression by a Salmonella Typhimurium wbaP Mutant”, PloS one, 11(5), p. e0154828. doi: 10.1371/journal.pone.0154828.   edoc
Moor, K., Wotzka, S. Y., Toska, A., Diard, M., Hapfelmeier, S. and Slack, E. (2016) “Peracetic Acid Treatment Generates Potent Inactivated Oral Vaccines from a Broad Range of Culturable Bacterial Species”, Frontiers in Immunology , 7(34), pp. 1–14. doi: 10.3389/fimmu.2016.00034.   edoc
Maier, L., Diard, M., Sellin, M. E., Chouffane, E.-S., Trautwein-Weidner, K., Periaswamy, B., Slack, E., Dolowschiak, T., Stecher, B., Loverdo, C., Regoes, R. R. and Hardt, W.-D. (2015) “Correction: Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis”, PLoS Pathogens, 11(7), p. e1005047. doi: 10.1371/journal.ppat.1005047.   edoc | Open Access
Maier, L., Diard, M., Sellin, M. E., Chouffane, E.-S., Trautwein-Weidner, K., Periaswamy, B., Slack, E., Dolowschiak, T., Stecher, B., Loverdo, C., Regoes, R. R. and Hardt, W.-D. (2014) “Granulocytes impose a tight bottleneck upon the gut luminal pathogen population during Salmonella typhimurium colitis”, PLoS Pathogens. Public Library of Science, 10(12), p. e1004557. doi: 10.1371/journal.ppat.1004557.   edoc | Open Access
Arnoldini, M., Vizcarra, I. A., Peña-Miller, R., Stocker, N., Diard, M., Vogel, V., Beardmore, R. E., Hardt, W.-D. and Ackermann, M. (2014) “Bistable expression of virulence genes in salmonella leads to the formation of an antibiotic-tolerant subpopulation”, PLoS Biology. Public Library of Science, 12(8), p. e1001928. doi: 10.1371/journal.pbio.1001928.   edoc | Open Access
Diard, M., Sellin, M. E., Dolowschiak, T., Arnoldini, M., Ackermann, M. and Hardt, W.-D. (2014) “Antibiotic treatment selects for cooperative virulence of Salmonella typhimurium”, Current Biology. Cell Press, 24(17), pp. 2000–2005. doi: 10.1016/j.cub.2014.07.028.   edoc
Sellin, M. E., Müller, A. A., Felmy, B., Dolowschiak, T., Diard, M., Tardivel, A., Maslowski, K. M. and Hardt, W.-D. (2014) “Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa”, Cell Host & Microbe. Cell Press, 16(2), pp. 237–248. doi: 10.1016/j.chom.2014.07.001.   edoc
Diard, M., Garcia, V., Maier, L., Remus-Emsermann, M. N. P., Regoes, R. R., Ackermann, M. and Hardt, W.-D. (2013) “Stabilization of cooperative virulence by the expression of an avirulent phenotype”, Nature. Macmillan, 494(7437), pp. 353–356. doi: 10.1038/nature11913.   edoc
Kaiser, P., Diard, M., Stecher, B. and Hardt, W.-D. (2012) “The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen’s virulence factors, and the host’s mucosal immune response”, Immunological Reviews. Wiley-Blackwell Publishing, 245(1), pp. 56–83. doi: 10.1111/j.1600-065X.2011.01070.x.   edoc
Tourret, J., Diard, M., Garry, L., Matic, I. and Denamur, E. (2010) “Effects of single and multiple pathogenicity island deletions on uropathogenic Escherichia coli strain 536 intrinsic extra-intestinal virulence”, International Journal of Medical Microbiology : IJMM. Elsevier, 300(7), pp. 435–439. doi: 10.1016/j.ijmm.2010.04.013.   edoc
Baeriswyl, S., Diard, M., Mosser, T., Leroy, M., Manière, X., Taddei, F. and Matic, I. (2010) “Modulation of aging profiles in isogenic populations of Caenorhabditis elegans by bacteria causing different extrinsic mortality rates”, Biogerontology. Springer, 11(1), pp. 53–65. doi: 10.1007/s10522-009-9228-0.   edoc
Diard, M., Garry, L., Selva, M., Mosser, T., Denamur, E. and Matic, I. (2010) “Pathogenicity-associated islands in extraintestinal pathogenic Escherichia coli are fitness elements involved in intestinal colonization”, Journal of Bacteriology. American Society for Microbiology, 192(19), pp. 4885–4893. doi: 10.1128/JB.00804-10.   edoc | Open Access
Touchon, M., Hoede, C., Tenaillon, O., Barbe, V., Baeriswyl, S., Bidet, P., Bingen, E., Bonacorsi, S., Bouchier, C., Bouvet, O., Calteau, A., Chiapello, H., Clermont, O., Cruveiller, S., Danchin, A., Diard, M., Dossat, C., Karoui, M. E., Frapy, E., Garry, L., Ghigo, J. M., Gilles, A. M., Johnson, J., Le Bouguénec, C., Lescat, M., Mangenot, S., Martinez-Jéhanne, V., Matic, I., Nassif, X., Oztas, S., Petit, M. A., Pichon, C., Rouy, Z., Ruf, C. S., Schneider, D., Tourret, J., Vacherie, B., Vallenet, D., Médigue, C., Rocha, E. P. C. and Denamur, E. (2009) “Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths”, PLoS Genetics. Public Library of Science, 5(1), p. e1000344. doi: 10.1371/journal.pgen.1000344.   edoc | Open Access
Diard, M., Baeriswyl, S., Clermont, O., Gouriou, S., Picard, B., Taddei, F., Denamur, E. and Matic, I. (2007) “Caenorhabditis elegans as a simple model to study phenotypic and genetic virulence determinants of extraintestinal pathogenic Escherichia coli”, Microbes and Infection. Elsevier, 9(2), pp. 214–223. doi: 10.1016/j.micinf.2006.11.009.   edoc