Publications

Börsch, A., Ham, D. J., Mittal, N., Tintignac, L. A., Migliavacca, E., Feige, J. N., Rüegg, M. A. and Zavolan, M. (2021) “Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia”, Communications biology, 4(1), p. 194. doi: 10.1038/s42003-021-01723-z.   
Ham, D. J., Börsch, A., Lin, S., Thürkauf, M., Weihrauch, M., Reinhard, J. R., Delezie, J., Battilana, F., Wang, X., Kaiser, M. S., Guridi, M., Sinnreich, M., Rich, M. M., Mittal, N., Tintignac, L. A., Handschin, C., Zavolan, M. and Rüegg, M. A. (2020) “The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia”, Nature Communications. Nature Publishing Group, 11(1), p. 4510. doi: 10.1038/s41467-020-18140-1.   edoc
Ham, A. S., Chojnowska, K., Tintignac, L. A., Lin, S., Schmidt, A., Ham, D. J., Sinnreich, M. and Rüegg, M. A. (2020) “mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice”, Journal of cachexia, sarcopenia and muscle. Springer, 11(1), pp. 259–273. doi: 10.1002/jcsm.12505.   edoc
Castets, P., Ham, D. J. and Rüegg, M. A. (2020) “The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player?”, Frontiers in molecular neuroscience, 13, p. 162. doi: 10.3389/fnmol.2020.00162.   
Pereira, J. A., Gerber, J., Ghidinelli, M., Gerber, D., Tortola, L., Ommer, A., Bachofner, S., Santarella, F., Tinelli, E., Lin, S., Rüegg, M. A., Kopf, M., Toyka, K. V. and Suter, U. (2020) “Mice carrying an analogous heterozygous Dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy”, Human molecular genetics, epub ahead of print, p. ddaa034. doi: 10.1093/hmg/ddaa034.   
Ding, X., Willenborg, S., Bloch, W., Wickström, S. A., Wagle, P., Brodesser, S., Roers, A., Jais, A., Brüning, J. C., Hall, M. N., Rüegg, M. A. and Eming, S. A. (2019) “Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation”, The Journal of Allergy & Clinical Immunology. Elsevier, 145(1), pp. 283–300.E8. doi: 10.1016/j.jaci.2019.07.033.   edoc
Donadon, I., Bussani, E., Riccardi, F., Licastro, D., Romano, G., Pianigiani, G., Pinotti, M., Kostantinova, P., Evers, M., Lin, S., Rüegg, M. A. and Pagani, F. (2019) “Rescue of spinal muscular atrophy mouse models with AAV9-Exon-specific U1 snRNA ”, Nucleic acids research. Oxford University Press, 47(14), pp. 7618–7632. doi: 10.1093/nar/gkz469.   edoc
Rion, N., Castets, P., Lin, S., Enderle, L., Reinhard, J. R. and Rüegg, M. A. (2019) “mTORC2 affects the maintenance of the muscle stem cell pool”, Skeletal Muscle. BioMed Central, 9(1), p. 30. doi: 10.1186/s13395-019-0217-y.   edoc
Delezie, J., Weihrauch, M., Maier, G., Tejero, R., Ham, D. J., Gill, J. F., Karrer-Cardel, B., Rüegg, M. A., Tabares, L. and Handschin, C. (2019) “BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle”, Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences , 116(32), pp. 16111–16120. doi: 10.1073/pnas.1900544116.   edoc
Castets, P., Rion, N., Théodore, M., Falcetta, D., Lin, S., Reischl, M., Wild, F., Guérard, L., Eickhorst, C., Brockhoff, M., Guridi, M., Ibebunjo, C., Cruz, J., Sinnreich, M., Rudolf, R., Glass, D. J. and Rüegg, M. A. (2019) “mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4”, Nature communications. Nature Research, 10(1), p. 3187. doi: 10.1038/s41467-019-11227-4.   edoc | Open Access
Rion, N., Castets, P., Lin, S., Enderle, L., Reinhard, J. R., Eickhorst, C. and Rüegg, M. A. (2019) “mTOR controls embryonic and adult myogenesis via mTORC1”, Development. The Company of Biologists, 146(7), pp. 1–15. doi: 10.1242/dev.172460.   edoc | Open Access
Yurchenco, P. D., McKee, K. K., Reinhard, J. R. and Rüegg, M. A. (2018) “Laminin-deficient muscular dystrophy: Molecular pathogenesis and structural repair strategies”, Matrix biology : journal of the International Society for Matrix Biology. Elsevier, 71-72, pp. 174–187. doi: 10.1016/j.matbio.2017.11.009.   edoc
Zainul, Z., Heikkinen, A., Koivisto, H., Rautalahti, I., Kallio, M., Lin, S., Härönen, H., Norman, O., Rüegg, M. A., Tanila, H. and Pihlajaniemi, T. (2018) “Collagen XIII Is Required for Neuromuscular Synapse Regeneration and Functional Recovery after Peripheral Nerve Injury”, The Journal of neuroscience. Society for Neuroscience, 38(17), pp. 4243–4258. doi: 10.1523/JNEUROSCI.3119-17.2018.   edoc | Open Access
van Putten, M., Aartsma-Rus, A., Grounds, M. D., Kornegay, J. N., Mayhew, A., Gillingwater, T. H., Takeda, S., Rüegg, M. A., De Luca, A., Nagaraju, K. and Willmann, R. (2018) “Update on Standard Operating Procedures in Preclinical Research for DMD and SMA Report of TREAT-NMD Alliance Workshop, Schiphol Airport, 26 April 2015, The Netherlands”, Journal of Neuromuscular Diseases. IOS Press, 5(1), pp. 29–34. doi: 10.3233/JND-170288.   edoc | Open Access
Boido, M., De Amicis, E., Valsecchi, V., Trevisan, M., Ala, U., Ruegg, M. A., Hettwer, S. and Vercelli, A. (2018) “Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy”, Frontiers in cellular neuroscience. Frontiers Media, 12, p. 17. doi: 10.3389/fncel.2018.00017.   edoc | Open Access
Karakatsani, A., Marichal, N., Urban, S., Kalamakis, G., Ghanem, A., Schick, A., Zhang, Y., Conzelmann, K.-K., Rüegg, M. A., Berninger, B., Ruiz de Almodovar, C., Gascón, S. and Kröger, S. (2017) “Neuronal LRP4 regulates synapse formation in the developing CNS”, Development. Company of Biologists, 144(24), pp. 4604–4615. doi: 10.1242/dev.150110.   edoc | Open Access
Hodson, N., McGlory, C., Oikawa, S. Y., Jeromson, S., Song, Z., Ruegg, M. A., Hamilton, D. L., Phillips, S. M. and Philp, A. (2017) “Differential localisation and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise”, American Journal of Physiology - Cell Physiology. American Physiological Society, 313(6), pp. C604-C611. doi: 10.1152/ajpcell.00176.2017.   edoc | Open Access
Hoffman, E. P. (2017) “Facilitating orphan drug development: Proceedings of the TREAT-NMD International Conference, December 2015, Washington, DC, USA”, Neuromuscular Disorders. Elsevier, 27(7), pp. 693–701. doi: 10.1016/j.nmd.2017.02.013.   edoc
Kleinert, M., Parker, B. L., Fritzen, A. M., Knudsen, J. R., Jensen, T. E., Kjøbsted, R., Sylow, L., Ruegg, M., James, D. E. and Richter, E. A. (2017) “Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice”, Journal of Physiology. Wiley, 595(14), pp. 4845–4855. doi: 10.1113/JP274203.   edoc | Open Access
Reinhard, J. R., Lin, S., McKee, K. K., Meinen, S., Crosson, S. C., Sury, M., Hobbs, S., Maier, G., Yurchenco, P. D. and Rüegg, M. A. (2017) “Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice”, Science Translational Medicine. American Association for the Advancement of Science, 9(396), p. eaal4649. doi: 10.1126/scitranslmed.aal4649.   edoc | Open Access
Fitter, S., Matthews, M. P., Martin, S. K., Xie, J., Ooi, S. S., Walkley, C. R., Codrington, J. D., Ruegg, M. A., Hall, M. N., Proud, C. G., Gronthos, S. and Zannettino, A. C. W. (2017) “mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation”, Molecular and Cellular Biology. American Society for Microbiology, 37(7), pp. e00668–16. doi: 10.1128/MCB.00668-16.   edoc | Open Access
Brockhoff, M., Rion, N., Chojnowska, K., Wiktorowicz, T., Eickhorst, C., Erne, B., Frank, S., Angelini, C., Furling, D., Rüegg, M. A., Sinnreich, M. and Castets, P. (2017) “Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I”, Journal of Clinical Investigation. American Society for Clinical Investigation, 127(2), pp. 549–563. doi: 10.1172/JCI89616.   edoc | Open Access
McKee, K. K., Crosson, S. C., Meinen, S., Reinhard, J. R., Rüegg, M. A. and Yurchenco, P. D. (2017) “Chimeric protein repair of laminin polymerization ameliorates muscular dystrophy phenotype”, Journal of Clinical Investigation. American Society for Clinical Investigation, 127(3), pp. 1075–1089. doi: 10.1172/JCI90854.   edoc | Open Access
Rion, N. and Rüegg, M. A. (2017) “LncRNA-encoded peptides: More than translational noise?”, Cell Research. Institute of Biochemistry and Cell Biology, 27(5), pp. 604–605. doi: 10.1038/cr.2017.35.   edoc | Open Access
Willmann, R., Gordish-Dressman, H., Meinen, S., Rüegg, M. A., Yu, Q., Nagaraju, K., Kumar, A., Girgenrath, M., Coffey, C. B. M., Cruz, V., Van Ry, P. M., Bogdanik, L., Lutz, C., Rutkowski, A. and Burkin, D. J. (2017) “Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy”, Journal of Neuromuscular Diseases. IOS Press, 4(2), pp. 115–126. doi: 10.3233/JND-170217.   edoc | Open Access
Reinhard, J. R., Kriz, A., Galic, M., Angliker, N., Rajalu, M., Vogt, K. E. and Rüegg, M. A. (2016) “The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory”, Nature Communications. Nature Publishing Group, 7, p. 11613. doi: 10.1038/ncomms11613.   edoc | Open Access
Guridi, M., Kupr, B., Romanino, K., Lin, S., Falcetta, D., Tintignac, L. and Rüegg, M. A. (2016) “Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism”, Skeletal Muscle. BioMed Central, 6(13), pp. 1–14. doi: 10.1186/s13395-016-0084-8.   edoc | Open Access
Schell, C., Kretz, O., Liang, W., Kiefer, B., Schneider, S., Sellung, D., Bork, T., Leiber, C., Rüegg, M. A., Mallidis, C., Schlatt, S., Mayerhofer, A., Huber, T. B. and Grahammer, F. (2016) “The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility”, American Journal of Pathology. American Society for Investigative Pathology, 186(2), pp. 324–336. doi: 10.1016/j.ajpath.2015.10.012.   edoc
Ruegsegger, C., Stucki, D. M., Steiner, S., Angliker, N., Radecke, J., Keller, E., Zuber, B., Rüegg, M. A. and Saxena, S. (2016) “Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology”, Neuron. Elsevier, 89(1), pp. 129–146. doi: 10.1016/j.neuron.2015.11.033.   edoc
Kleinert, M., Parker, B. L., Chaudhuri, R., Fazakerley, D. J., Serup, A., Thomas, K. C., Krycer, J. R., Sylow, L., Fritzen, A. M., Hoffman, N. J., Jeppesen, J., Schjerling, P., Rüegg, M. A., Kiens, B., James, D. E. and Richter, E. A. (2016) “mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3”, Molecular Metabolism. Elsevier, 5(8), pp. 646–655. doi: 10.1016/j.molmet.2016.06.007.   edoc | Open Access
Ding, X., Bloch, W., Iden, S., Rüegg, M. A., Hall, M. N., Leptin, M., Partridge, L. and Eming, S. A. (2016) “mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation”, Nature Communications. Nature Publishing Group, 7, p. 13226. doi: 10.1038/ncomms13226.   edoc | Open Access
Castets, P., Frank, S., Sinnreich, M. and Rüegg, M. A. (2016) “‘Get the Balance Right’: Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders”, Journal of Neuromuscular Diseases. IOS Press, 3(2), pp. 127–155. doi: 10.3233/JND-160153.   edoc
Shende, P., Xu, L., Morandi, C., Pentassuglia, L., Heim, P., Lebboukh, S., Berthonneche, C., Pedrazzini, T., Kaufmann, B. A., Hall, M. N., Rüegg, M. A. and Brink, M. (2016) “Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy”, Cardiovascular Research. Oxford University Press, 109(1), pp. 103–114. doi: 10.1093/cvr/cvv252.   edoc | Open Access
Aimi, F., Georgiopoulou, S., Kalus, I., Lehner, F., Hegglin, A., Limani, P., Gomes de Lima, V., Rüegg, M. A., Hall, M. N., Lindenblatt, N., Haas, E., Battegay, E. J. and Humar, R. (2015) “Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult”, Scientific Reports. Nature Publishing Group, 5, p. 17705. doi: 10.1038/srep17705.   edoc | Open Access
Guridi, M., Tintignac, L. A., Lin, S., Kupr, B., Castets, P. and Rüegg, M. A. (2015) “Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21”, Science Signaling. American Association for the Advancement of Science, 8(402), p. ra113. doi: 10.1126/scisignal.aab3715.   edoc
Angliker, N., Burri, M., Zaichuk, M., Fritschy, J.-M. and Rüegg, M. A. (2015) “mTORC1 and mTORC2 have largely distinct functions in Purkinje cells”, European Journal of Neuroscience. Wiley, 42(8), pp. 2595–2612. doi: 10.1111/ejn.13051.   edoc | Open Access
Willmann, R., De Luca, A. ., Nagaraju, K. and Rüegg, M. A. (2015) “Best Practices and Standard Protocols as a Tool to Enhance Translation for Neuromuscular Disorders”, Journal of Neuromuscular Diseases. IOS Press, 2(2), pp. 113–117. doi: 10.3233/JND-140067.   edoc | Open Access
Domi, T., Porrello, E., Velardo, D., Capotondo, A., Biffi, A., Tonlorenzi, R., Amadio, S., Ambrosi, A., Miyagoe-Suzuki, Y., Takeda, S., Ruegg, M. A. and Previtali, S. C. (2015) “Mesoangioblast delivery of miniagrin ameliorates murine model of merosin-deficient congenital muscular dystrophy type 1A”, Skeletal Muscle. BioMed Central, 5(30), pp. 1–17. doi: 10.1186/s13395-015-0055-5.   edoc | Open Access
Tintignac, L. A., Brenner, H.-R. and Rüegg, M. A. (2015) “Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting”, Physiological Reviews. American Physiological Society, 95(3), pp. 809–852. doi: 10.1152/physrev.00033.2014.   edoc
Ma, S., Venkatesh, A., Langellotto, F., Le, Y. Z., Hall, M. N., Rüegg, M. A. and Punzo, C. (2015) “Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival”, Experimental Eye Research. Academic Press, 135, pp. 1–13. doi: 10.1016/j.exer.2015.04.006.   edoc | Open Access
Martin, S. K., Fitter, S., Dutta, A. K., Matthews, M. P., Walkley, C. R., Hall, M. N., Ruegg, M. A., Gronthos, S. and Zannettino, A. C. W. (2015) “Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation”, Stem cells. AlphaMed Press, Vol. 33, H. 4, pp. 1359–1365. doi: 10.1002/stem.1931.   edoc
Carr, T. D., Feehan, R. P., Hall, M. N., Rüegg, M. A. and Shantz, L. M. (2015) “Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors”, Carcinogenesis. Oxford University Press, 36(4), pp. 487–497. doi: 10.1093/carcin/bgv012.   edoc | Open Access
Venkatesh, A., Ma, S., Le, Y. Z., Hall, M. N., Rüegg, M. A. and Punzo, C. (2015) “Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice”, Journal of Clinical Investigation. American Society for Clinical Investigation, 125(4), pp. 1446–1458. doi: 10.1172/JCI79766.   edoc | Open Access
Lopez, R. J., Mosca, B., Treves, S., Maj, M., Bergamelli, L., Calderon, J. C., Bentzinger, C. F., Romanino, K., Hall, M. N., Rüegg, M. A., Delbono, O., Caputo, C. and Zorzato, F. (2015) “Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex”, Biochemical Journal. Portland Press, 466(1), pp. 123–135. doi: 10.1042/BJ20140935.   edoc | Open Access
Zhang, Y., Lin, S., Karakatsani, A., Rüegg, M. A. and Kröger, S. (2015) “Differential regulation of AChR clustering in the polar and equatorial region of murine muscle spindles”, European Journal of Neuroscience. Wiley, 41(1), pp. 69–78. doi: 10.1111/ejn.12768.   edoc
Steiner, E., Enzmann, G. U., Lyck, R., Lin, S., Rüegg, M. A., Kröger, S. and Engelhardt, B. (2014) “The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions”, Cell and Tissue Research. Springer, 358(2), pp. 465–479. doi: 10.1007/s00441-014-1969-7.   edoc | Open Access
Hettwer, S., Lin, S., Kucsera, S., Haubitz, M., Oliveri, F., Fariello, R. G., Ruegg, M. A. and Vrijbloed, J. W. (2014) “Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction”, PLoS ONE. Public Library of Science, 9(2), p. e88739. doi: 10.1371/journal.pone.0088739.   edoc | Open Access
Kleinert, M., Sylow, L., Fazakerley, D. J., Krycer, J. R., Thomas, K. C., Oxbøll, A.-J., Jordy, A. B., Jensen, T. E., Yang, G., Schjerling, P., Kiens, B., James, D. E., Ruegg, M. A. and Richter, E. A. (2014) “Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo”, Molecular Metabolism. Elsevier, 3(6), pp. 630–641. doi: 10.1016/j.molmet.2014.06.004.   edoc | Open Access
Miloslavski, R., Cohen, E., Avraham, A., Iluz, Y., Hayouka, Z., Kasir, J., Mudhasani, R., Jones, S. N., Cybulski, N., Rüegg, M. A., Larsson, O., Gandin, V., Rajakumar, A., Topisirovic, I. and Meyuhas, O. (2014) “Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner”, Journal of Molecular Cell Biology. Oxford University Press, 6(3), pp. 255–266. doi: 10.1093/jmcb/mju008.   edoc | Open Access
Norrmén, C., Figlia, G., Lebrun-Julien, F., Pereira, J. A., Trötzmüller, M., Köfeler, H. C., Rantanen, V., Wessig, C., van Deijk, A. F., Smit, A. B., Verheijen, M. G., Rüegg, M. A., Hall, M. N. and Suter, U. (2014) “mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells”, Cell Reports . Elsevier, 9(2), pp. 646–660. doi: 10.1016/j.celrep.2014.09.001.   edoc | Open Access
Zhang, L., Tschumi, B. O., Corgnac, S., Rüegg, M. A., Hall, M. N., Mach, J.-P., Romero, P. and Donda, A. (2014) “Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function”, Journal of Immunology. American Association of Immunologists, 193(4), pp. 1759–1765. doi: 10.4049/jimmunol.1400769.   edoc
Grahammer, F., Haenisch, N., Steinhardt, F., Sander, L., Roerden, M., Arnold, F., Cordts, T., Wanner, N., Reichardt, W., Kerjaschki, D., Ruegg, M. A., Hall, M. N., Moulin, P., Busch, H., Boerries, M., Walz, G., Artunc, F. and Huber, T. B. (2014) “mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress”, Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 111(27), pp. E2817-E2826. doi: 10.1073/pnas.1402352111.   edoc | Open Access
Chou, P.-C., Oh, W. J., Wu, C.-C., Moloughney, J., Rüegg, M. A., Hall, M. N., Jacinto, E. and Werlen, G. (2014) “Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development”, Journal of Immunology. American Association of Immunologists, 193(3), pp. 1162–1170. doi: 10.4049/jimmunol.1303162.   edoc | Open Access
Lebrun-Julien, F., Bachmann, L., Norrmén, C., Trötzmüller, M., Köfeler, H., Rüegg, M. A., Hall, M. N. and Suter, U. (2014) “Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination”, Journal of Neuroscience. Society for Neuroscience, 34(25), pp. 8432–8448. doi: 10.1523/JNEUROSCI.1105-14.2014.   edoc | Open Access
Chen, J., Tu, X., Esen, E., Joeng, K. S., Lin, C., Arbeit, J. M., Rüegg, M. A., Hall, M. N., Ma, L. and Long, F. (2014) “WNT7B promotes bone formation in part through mTORC1”, PLoS Genetics. Public Library of Science, 10(1), p. e1004145. doi: 10.1371/journal.pgen.1004145.   edoc | Open Access
Angliker, N. and Rüegg, M. A. (2013) “In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neurons”, Bioarchitecture. Taylor & Francis, 3(4), pp. 113–118. doi: 10.4161/bioa.26497.   edoc | Open Access
Castets, P. and Rüegg, M. A. (2013) “MTORC1 determines autophagy through ULK1 regulation in skeletal muscle”, Autophagy. Taylor & Francis, 9(9), pp. 1435–1437. doi: 10.4161/auto.25722.   edoc | Open Access
Song, J., Lokmic, Z., Lämmermann, T., Rolf, J., Wu, C., Zhang, X., Hallmann, R., Hannocks, M.-J., Horn, N., Ruegg, M. A., Sonnenberg, A., Georges-Labouesse, E., Winkler, T. H., Kearney, J. F., Cardell, S. and Sorokin, L. (2013) “Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival”, Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 110(31), pp. 2915-E2924. doi: 10.1073/pnas.1218131110.   edoc | Open Access
Castets, P., Lin, S., Rion, N., Di Fulvio, S., Romanino, K., Guridi, M., Frank, S., Tintignac, L. A., Sinnreich, M. and Ruegg, M. A. (2013) “Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy”, Cell metabolism. Elsevier, 17(5), pp. 731–744. doi: 10.1016/j.cmet.2013.03.015.   edoc
Cloëtta, D., Thomanetz, V., Baranek, C., Lustenberger, R. M., Lin, S., Oliveri, F., Atanasoski, S. and Rüegg, M. A. (2013) “Inactivation of mTORC1 in the Developing Brain Causes Microcephaly and Affects Gliogenesis”, Journal of neuroscience. Society for Neuroscience, Vol. 33, H. 18, pp. 7799–7810. doi: 10.1523/JNEUROSCI.3294-12.2013.   edoc | Open Access
Thomanetz, V., Angliker, N., Cloëtta, D., Lustenberger, R. M., Schweighauser, M., Oliveri, F., Suzuki, N. and Rüegg, M. A. (2013) “Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology”, The journal of cell biology. Rockefeller University Press, Vol. 201, H. 2, pp. 293–308. doi: 10.1083/jcb.201205030.   edoc | Open Access
Bentzinger, C. F., Lin, S., Romanino, K., Castets, P., Guridi, M., Summermatter, S., Handschin, C., Tintignac, L. A., Hall, M. N. and Rüegg, M. A. (2013) “Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy”, Skeletal muscle. BioMed Central, Vol. 3, H. 1 , 6. doi: 10.1186/2044-5040-3-6.   edoc | Open Access
Steiner, E., Enzmann, G. U., Lin, S., Ghavampour, S., Hannocks, M.-J., Zuber, B., Rüegg, M. A., Sorokin, L. and Engelhardt, B. (2012) “Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation”, Glia. Wiley Liss, 60(11), pp. 1646–1659. doi: 10.1002/glia.22383 .   edoc
Blättler, S. M., Verdeguer, F., Liesa, M., Cunningham, J. T., Vogel, R. O., Chim, H., Liu, H., Romanino, K., Shirihai, O. S., Vazquez, F., Rüegg, M. A., Shi, Y. and Puigserver, P. (2012) “Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle”, Molecular and cellular biology. American Society for Microbiology, 32(16), pp. 3333–3346. doi: 10.1128/MCB.00337-12.   edoc | Open Access
Meinen, S., Lin, S. and Ruegg, M. A. (2012) “Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-alpha2-deficient congenital muscular dystrophy (MDC1A)”, Skeletal muscle. BioMed Central, Vol. 2, H. 1, p. 18.   edoc | Open Access
Meinen, S., Lin, S., Rüegg, M. A. and Punga, A. R. (2012) “Fatigue and Muscle Atrophy in a Mouse Model of Myasthenia Gravis Is Paralleled by Loss of Sarcolemmal nNOS”, PLoS ONE. Public Library of Science, Vol. 7, H. 8 , e44148.   edoc | Open Access
Blättler, S. M., Cunningham, J. T., Verdeguer, F., Chim, H., Haas, W., Liu, H., Romanino, K., Rüegg, M. A., Gygi, S. P., Shi, Y. and Puigserver, P. (2012) “Yin yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling”, Cell Metabolism. Cell Press, 15(4), pp. 505–517. doi: 10.1016/j.cmet.2012.03.008.   edoc | Open Access
Punga, A. R. and Ruegg, M. A. (2012) “Signaling and aging at the neuromuscular synapse : lessons learnt from neuromuscular diseases”, Current Opinion in Pharmacology. Elsevier, 12(3), pp. 340–346. doi: 10.1016/j.coph.2012.02.002.   edoc
Hagiwara, A., Cornu, M., Cybulski, N., Polak, P., Betz, C., Trapani, F., Terracciano, L., Heim, M. H., Rüegg, M. A. and Hall, M. N. (2012) “Hepatic mTORC2 activates glycolysis and lipogenesis through akt, glucokinase, and SREBP1c”, Cell Metabolism. Cell Press, 15(5), pp. 725–738. doi: 10.1016/j.cmet.2012.03.015.   edoc
Romanino, K., Mazelin, L., Albert, V., Conjard-Duplany, A., Lin, S., Bentzinger, C. F., Handschin, C., Puigserver, P., Zorzato, F., Schaeffer, L., Gangloff, Y.-G. and Rüegg, M. A. (2011) “Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function”, Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, Vol. 108, H. 51, pp. 20808–20813.   edoc | Open Access
Rieker, C., Dev, K. K., Lehnhoff, K., Barbieri, S., Ksiazek, I., Kauffmann, S., Danner, S., Schell, H., Boden, C., Ruegg, M. A., Kahle, P. J., van der Putten, H. and Shimshek, D. R. (2011) “Neuropathology in mice expressing mouse alpha-synuclein”, PLoS ONE. Public Library of Science, Vol. 6, H. 9 , e24834.   edoc | Open Access
Meinen, S., Lin, S., Thurnherr, R., Erb, M., Meier, T. and Rüegg, M. A. (2011) “Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice”, EMBO Molecular Medicine. Wiley-Blackwell, 3(8), pp. 465–479. doi: 10.1002/emmm.201100151.   edoc | Open Access
Punga, A. R., Maj, M., Lin, S., Meinen, S. and Ruegg, M. A. (2011) “MuSK levels differ between adult skeletal muscles and influence postsynaptic plasticity”, The European journal of neuroscience. Blackwell, Vol. 33, H. 5, pp. 890–898. doi: 10.1111/j.1460-9568.2010.07569.x.   edoc
Punga, A. R., Lin, S., Oliveri, F., Meinen, S. and Ruegg, M. A. (2011) “Muscle-selective synaptic disassembly and reorganization in MuSK antibody positive MG mice”, Experimental Neurology. Academic Press, 230(2), pp. 207–217. doi: 10.1016/j.expneurol.2011.04.018.   edoc
Shende, P., Plaisance, I., Morandi, C., Pellieux, C., Berthonneche, C., Zorzato, F., Krishnan, J., Lerch, R., Hall, M. N., Ruegg, M. A., Pedrazzini, T. and Brink, M. (2011) “Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice”, Circulation. Lippincott Williams & Wilkins, 123(10), pp. 1073–1082. doi: 10.1161/CIRCULATIONAHA.110.977066.   edoc
Godel, M., Hartleben, B., Herbach, N., Liu, S., Zschiedrich, S., Lu, S., Debreczeni-Mor, A., Lindenmeyer, M. T., Rastaldi, M. .-P., Hartleben, G., Wiech, T., Fornoni, A., Nelson, R. G., Kretzler, M., Wanke, R., Pavenstadt, H., Kerjaschki, D., Cohen, C. D., Hall, M. N., Ruegg, M. A., Inoki, K., Walz, G. and Huber, T. B. (2011) “Role of mTOR in podocyte function and diabetic nephropathy in humans and mice”, Journal of Clinical Investigation. American Society for Clinical Investigation, 121(6), pp. 2197–2209. doi: 10.1172/JCI44774.   edoc | Open Access
Inoki, K., Mori, H., Wang, J., Suzuki, T., Hong, S., Yoshida, S., Blattner, S. M., Ikenoue, T., Ruegg, M. A., Hall, M. N., Kwiatkowski, D. J., Rastaldi, M. P., Huber, T. B., Kretzler, M., Holzman, L. B., Wiggins, R. C. and Guan, K. .-L. (2011) “mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice”, Journal of Clinical Investigation. American Society for Clinical Investigation, 121(6), pp. 2181–2196. doi: 10.1172/JCI44771.   edoc | Open Access
Escher, C., Lochmüller, H., Fischer, D., Frank, S., Reimann, J., Walter, M. C., Ehrat, M., Ruegg, M. A. and Gygax, D. (2010) “Reverse protein arrays as novel approach for protein quantification in muscular dystrophies”, Neuromuscular disorders. Pergamon Press, 20, pp. 302–309.   edoc
Rüegg, M. A. and Glass, D. J. (2010) “Molecular mechanisms and treatment options for muscle wasting eiseases”, Annual Review of Pharmacology and Toxicology. Annual Review, 51, pp. 373–395. doi: 10.1146/annurev-pharmtox-010510-100537.   edoc
Risson, V., Mazelin, L., Roceri, M., Sanchez, H., Moncollin, V., Corneloup, C., Richard-Bulteau, H., Vignaud, A., Baas, D., Defour, A., Freyssenet, D., Tanti, J.-F., Le-Marchand-Brustel, Y., Ferrier, B., Conjard-Duplany, A., Romanino, K., Bauché, S., Hantaï, D., Mueller, M., Kozma, S. C., Thomas, G., Rüegg, M. A., Ferry, A., Pende, M., Bigard, X., Koulmann, N., Schaeffer, L. and Gangloff, Y.-G. (2009) “Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy”, The Journal of cell biology. Rockefeller University Press, Vol. 187, H. 6, pp. 859–874. doi: 10.1083/jcb.200903131.   edoc | Open Access
Willmann, R., Possekel, S., Dubach-Powell, J., Meier, T. and Rüegg, M. A. (2009) “Mammalian animal models for Duchenne muscular dystrophy”, Neuromuscular Disorders. Elsevier, 19 (4), pp. 241–249. doi: 10.1016/j.nmd.2008.11.015.   edoc
Erb, M., Meinen, S., Barzaghi, P., Sumanovski, L. T., Courdier-Fruh, I., Ruegg, M. A. and Meier, T. (2009) “Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-α2 deficiency”, Journal of pharmacology and experimental therapeutics. Williams and Wilkins, 331(3), pp. 787–795. doi: 10.1124/jpet.109.160754.   edoc
Huze, C., Bauche, S., Richard, P., Chevessier, F., Goillot, E., Gaudon, K., Ben Ammar, A., Chaboud, A., Grosjean, I., Lecuyer, H. .-A., Bernard, V., Rouche, A., Alexandri, N., Kuntzer, T., Fardeau, M., Fournier, E., Brancaccio, A., Ruegg, M. A., Koenig, J., Eymard, B., Schaeffer, L. and Hantai, D. (2009) “Identification of an agrin mutation that causes congenital myasthenia and affects synapse function”, American Journal of Human Genetics. Univ. of Chicago Press, 85(2), pp. 155–167. doi: 10.1016/j.ajhg.2009.06.015.   edoc | Open Access
Patursky-Polischuk, I., Stolovich-Rain, M., Hausner-Hanochi, M., Kasir, J., Cybulski, N., Avruch, J., Ruegg, M. A., Hall, M. N. and Meyuhas, O. (2009) “The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner”, Molecular and cellular biology. American Society for Microbiology, Vol. 29, H. 3, pp. 640–649. doi: 10.1128/MCB.00980-08.   edoc | Open Access
Cybulski, N., Polak, P., Auwerx, J., Ruegg, M. A. and Hall, M. N. (2009) “mTOR complex 2 in adipose tissue negatively controls whole-body growth”, Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 106(24), pp. 9902–9907. doi: 10.1073/pnas.0811321106.   edoc | Open Access
Bentzinger, C. F., Romanino, K., Cloetta, D., Lin, S., Mascarenhas, J. B., Oliveri, F., Xia, J., Casanova, E., Costa, C. F., Brink, M., Zorzato, F., Hall, M. N. and Ruegg, M. A. (2008) “Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy”, Cell Metabolism. Cell Press, 8(5), pp. 411–424. doi: 10.1016/j.cmet.2008.10.002.   edoc
Polak, P., Cybulski, N., Feige, J. N., Auwerx, J., Ruegg, M. A. and Hall, M. N. (2008) “Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration”, Cell Metabolism. Cell Press, Vol. 8, H. 5, pp. 399–410. doi: 10.1016/j.cmet.2008.09.003.   edoc
Lin, S., Landmann, L., Ruegg, M. A. and Brenner, H. R. (2008) “The role of nerve- versus muscle-derived factors in mammalian neuromuscular junction formation”, Journal of neuroscience. Society for Neuroscience, Vol. 28, H. 13, pp. 3333–3340. doi: 10.1523/JNEUROSCI.5590-07.2008.   edoc | Open Access
Lin, S., Maj, M., Bezakova, G., Magyar, J. P., Brenner, H. R. and Ruegg, M. A. (2008) “Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice”, Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 105(32), pp. 11406–11411. doi: 10.1073/pnas.0801683105.   edoc | Open Access
Reiterer, V., Maier, S., Sitte, H. H., Kriz, A., Ruegg, M. A., Hauri, H. P., Freissmuth, M. and Farhan, H. (2008) “Sec24- and ARFGAP1-dependent trafficking of GABA transporter-1 is a prerequisite for correct axonal targeting”, Journal of Neuroscience. Society for Neuroscience, 28(47), pp. 12453–12464. doi: 10.1523/JNEUROSCI.3451-08.2008.   edoc | Open Access
Camilleri, A. A., Willmann, R., Sadasivam, G., Lin, S., Ruegg, M. A., Gesemann, M. and Fuhrer, C. (2007) “Tyrosine phosphatases such as SHP-2 act in a balance with Src-family kinases in stabilization of postsynaptic clusters of acetylcholine receptors”, BMC Neuroscience. BioMed Central, 8(46), pp. 1–16. doi: 10.1186/1471-2202-8-46.   edoc | Open Access
Ksiazek, I., Burkhardt, C., Lin, S., Seddik, R., Maj, M., Bezakova, G., Jucker, M., Arber, S., Caroni, P., Sanes, J. R., Bettler, B. and Ruegg, M. A. (2007) “Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death”, Journal of Neuroscience. Society for Neuroscience, 27(27), pp. 7183–7195. doi: 10.1523/JNEUROSCI.1609-07.2007.   edoc | Open Access
Plachta, N., Annaheim, C., Bissiere, S., Lin, S., Ruegg, M., Hoving, S., Muller, D., Poirier, F., Bibel, M. and Barde, Y. .-A. (2007) “Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells”, Nature neuroscience. Nature America, Vol. 10, H. 6, pp. 712–719. doi: 10.1038/nn1897.   edoc
Meinen, S., Barzaghi, P., Lin, S., Lochmuller, H. and Ruegg, M. A. (2007) “Linker molecules between laminins and dystroglycan ameliorate laminin-alpha2-deficient muscular dystrophy at all disease stages”, The Journal of cell biology. Rockefeller University Press, Vol. 176, H. 7, pp. 979–993. doi: 10.1083/jcb.200611152.   edoc | Open Access
Hausser, H.-J., Ruegg, M. A., Brenner, R. E. and Ksiazek, I. (2007) “Agrin is highly expressed by chondrocytes and is required for normal growth”, Histochemistry and Cell Biology. Springer, 127(4), pp. 363–374. doi: 10.1007/s00418-006-0258-2.   edoc | Open Access
Ruegg, M. A. (2006) “Commonalities and differences in muscular dystrophies : mechanisms and molecules involved in merosin-deficient congenital muscular dystrophy”, in Winder, S. J. (ed.) Molecular mechanisms of muscular dystrophies. Georgetown, Tex.: Eurekah.com (Molecular Biology Intelligence Unit), pp. 74–81.   edoc
Possekel, S., Meier, T. and Ruegg, M. A. (2006) “Peripheral signaling pathways involved in muscle loss”, in Pharmacotherapy of Cachexia. Boca Raton, FL, USA: CRC Press, pp. 543–564.   edoc
Meinen, S. and Ruegg, M. A. (2006) “Congenital muscular dystrophy: mini-agrin delivers in mice”, Gene Therapy. Nature Publishing Group, Vol. 13, H. 11, pp. 869–870.   edoc
Scotton, P., Bleckmann, D., Stebler, M., Sciandra, F., Brancaccio, A., Meier, T., Stetefeld, J. and Ruegg, M. A. (2006) “Activation of muscle-specific receptor tyrosine kinase and binding to dystroglycan are regulated by alternative mRNA splicing of agrin”, Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 281(48), pp. 36835–36845. doi: 10.1074/jbc.M607887200.   edoc
Jokic, N., Gonzalez de Aguilar, J. .-L., Dimou, L., Lin, S., Fergani, A., Ruegg, M. A., Schwab, M. E., Dupuis, L. and Loeffler, J. .-P. (2006) “The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model”, EMBO reports. Nature Publishing Group, Vol. 7, H. 11, pp. 1162–1167. doi: 10.1038/sj.embor.7400826.   edoc | Open Access
Annies, M., Bittcher, G., Ramseger, R., Loschinger, J., Woll, S., Porten, E., Abraham, C., Ruegg, M. A. and Kroger, S. (2006) “Clustering transmembrane-agrin induces filopodia-like processes on axons and dendrites”, Molecular and cellular neuroscience. Academic Press, Vol. 31, H. 3, pp. 515–524. doi: 10.1016/j.mcn.2005.11.005.   edoc
Stetefeld, J. and Ruegg, M. A. (2005) “Structural and functional diversity generated by alternative mRNA splicing”, Trends in biochemical sciences. Elsevier, Vol. 30, H. 9, pp. 515–521. doi: 10.1016/j.tibs.2005.07.001.   edoc
Bentzinger, C. F., Barzaghi, P., Lin, S. and Ruegg, M. A. (2005) “Overexpression of mini-agrin in skeletal muscle increases muscle integrity and regenerative capacity in laminin-alpha2-deficient mice”, FASEB Journal. Federation of American Society of Experimental Biology , 19(8), pp. 934–942. doi: 10.1096/fj.04-3376com.   edoc
Ruegg, M. A. (2005) “Organization of synaptic myonuclei by Syne proteins and their role during the formation of the nerve-muscle synapse”, Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 102(16), pp. 5643–5644. doi: 10.1073/pnas.0501516102.   edoc | Open Access
Mascarenhas, J. B., Ruegg, M. A., Sasaki, T., Eble, J. A., Engel, J. and Stetefeld, J. (2005) “Structure and laminin-binding specificity of the NtA domain expressed in eukaryotic cells”, Matrix Biology. Elsevier Science, Vol. 23, H. 8, pp. 507–513. doi: 10.1016/j.matbio.2004.11.003.   edoc
Smirnov, S. P., Barzaghi, P., McKee, K. K., Ruegg, M. A. and Yurchenco, P. D. (2005) “Conjugation of LG domains of agrins and perlecan to polymerizing laminin-2 promotes acetylcholine receptor clustering”, Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 280(50), pp. 41449–41457. doi: 10.1074/jbc.M508939200.   edoc
Madhavan, R., Zhao, X. T., Ruegg, M. A. and Peng, H. B. (2005) “Tyrosine phosphatase regulation of MuSK-dependent acetylcholine receptor clustering”, Molecular and cellular neuroscience. Elsevier, Vol. 28, H. 3, pp. 403–416.   edoc
Sadasivam, G., Willmann, R., Lin, S., Erb-Vogtli, S., Kong, X. C., Ruegg, M. A. and Fuhrer, C. (2005) “Src-family kinases stabilize the neuromuscular synapse in vivo via protein interactions, phosphorylation, and cytoskeletal linkage of acetylcholine receptors”, Journal of Neuroscience. Society for Neuroscience, 25(45), pp. 10479–10493. doi: 10.1523/JNEUROSCI.2103-05.2005.   edoc | Open Access
Stetefeld, J., Alexandrescu, A. T., Maciejewski, M. W., Jenny, M., Rathgeb-Szabo, K., Schulthess, T., Landwehr, R., Frank, S., Ruegg, M. A. and Kammerer, R. A. (2004) “Modulation of agrin function by alternative splicing and Ca2+ binding”, Structure: with folding and design. Current Biology, Vol. 12, H. 3, pp. 503–515. doi: 10.1016/j.str.2004.02.001.   edoc
Ruegg, M. A. and McMahan, U. J. (2004) “Agrin”, in Encyclopedia of Neuroscience. Amsterdam: Elsevier.   edoc
Kong, X. C., Barzaghi, P. and Ruegg, M. A. (2004) “Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference”, EMBO reports. Nature Publishing Group, Vol. 5, H. 2, pp. 183–188. doi: 10.1038/sj.embor.7400065.   edoc | Open Access
Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Ruegg, M. A., Hall, A. and Hall, M. N. (2004) “Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive”, Nature Cell Biology. MacMillan, Vol. 6, H. 11, pp. 1122–1128. doi: 10.1038/ncb1183.   edoc
Eusebio, A., Oliveri, F., Barzaghi, P. and Ruegg, M. A. (2003) “Expression of mouse agrin in normal, denervated and dystrophic muscle”, Neuromuscular Disorders. Pergamon Press, Vol. 13, H. 5, pp. 408–415. doi: 10.1016/S0960-8966(03)00036-1.   edoc
Guo, L. T., Zhang, X. U., Kuang, W., Xu, H., Liu, L. A., Vilquin, J. .-T., Miyagoe-Suzuki, Y., Takeda, S., Ruegg, M. A., Wewer, U. M. and Engvall, E. (2003) “Laminin alpha2 deficiency and muscular dystrophy : genotype-phenotype correlation in mutant mice”, Neuromuscular Disorders. Pergamon Press, Vol. 13, H. 3, pp. 207–215. doi: 10.1016/s0960-8966(02)00266-3.   edoc
Bartoccioni, E., Marino, M., Evoli, A., Ruegg, M. A., Scuderi, F. and Provenzano, C. (2003) “Identification of disease-specific autoantibodies in seronegative myasthenia gravis”, Annals of the New York Academy of Sciences. Wiley, 998, pp. 356–358. doi: 10.1196/annals.1254.041.   edoc
Mascarenhas, J. B., Ruegg, M. A., Winzen, U., Halfter, W., Engel, J. and Stetefeld, J. (2003) “Mapping of the laminin-binding site of the N-terminal agrin domain (NtA)”, The EMBO Journal. Nature Publishing Group, 22(3), pp. 529–536. doi: 10.1093/emboj/cdg041.   edoc | Open Access
Bezakova, G. and Ruegg, M. A. (2003) “New insights into the roles of agrin”, Nature reviews. Molecular cell biology. Nature Publishing Group, Vol. 4, H. 4, pp. 295–308. doi: 10.1038/nrm1074.   edoc
Pun, S., Sigrist, M., Santos, A. F., Ruegg, M. A., Sanes, J. R., Jessell, T. M., Arber, S. and Caroni, P. (2002) “An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles”, Neuron. Cell Press, Vol. 34, H. 3, pp. 357–370. doi: 10.1016/S0896-6273(02)00670-0.   edoc
Bixby, J. L., Baerwald-De la Torre, K., Wang, C., Rathjen, F. G. and Ruegg, M. A. (2002) “A neuronal inhibitory domain in the N-terminal half of agrin”, Journal of Neurobiology. Wiley, 50(2), pp. 164–179. doi: 10.1002/neu.10025.   edoc
Abicht, A., Stucka, R., Schmidt, C., Briguet, A., Hopfner, S., Song, I. .-H., Pongratz, D., Muller-Felber, W., Ruegg, M. A. and Lochmuller, H. (2002) “A newly identified chromosomal microdeletion and an N-box mutation of the AChR epsilon gene cause a congenital myasthenic syndrome”, Brain. Oxford University Press, 125(5), pp. 1005–1013. doi: 10.1093/brain/awf095.   edoc | Open Access
Ruegg, M. A. (2001) “Molecules involved in the formation of synaptic connections in muscle and brain”, Matrix Biology. Elsevier Science, Vol. 20, H. 1, pp. 3–12. doi: 10.1016/S0945-053X(00)00135-9.   edoc
Stetefeld, J., Jenny, M., Schulthess, T., Landwehr, R., Schumacher, B., Frank, S., Ruegg, M. A., Engel, J. and Kammerer, R. A. (2001) “The laminin-binding domain of agrin is structurally related to N-TIMP-1”, Nature Structural biology. Nature Publishing Co, Vol. 8, H. 8, pp. 705–709. doi: 10.1038/90422.   edoc
Neumann, F. R., Bittcher, G., Annies, M., Schumacher, B., Kroger, S. and Ruegg, M. A. (2001) “An alternative amino-terminus expressed in the central nervous system converts agrin to a type II transmembrane protein”, Molecular and cellular neuroscience. Elsevier, 17(1), pp. 208–225. doi: 10.1006/mcne.2000.0932.   edoc
Alexandrescu, A. T., Maciejewski, M. W., Ruegg, M. A., Engel, J. and Kammerer, R. A. (2001) “1H, 13C and 15N backbone assignments for the C-terminal globular domain of agrin”, Journal of Biomolecular NMR. Springer, 20(3), pp. 295–296. doi: 10.1023/A:1011256008944.   edoc
Moll, J., Barzaghi, P., Lin, S., Bezakova, G., Lochmuller, H., Engvall, E., Muller, U. and Ruegg, M. A. (2001) “An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy”, Nature. Macmillan, 413(6853), pp. 302–307. doi: 10.1038/35095054.   edoc
Sommer, B., Barbieri, S., Hofele, K., Wiederhold, K., Probst, A., Mistl, C., Danner, S., Kauffmann, S., Spooren, W., Tolnay, M., Bilbe, G., Kafmann, S., Caromi, P. and Ruegg, M. A. (2000) “Mouse models of alpha-synucleinopathy and Lewy pathology”, Experimental gerontology. Pergamon Press, Vol. 35, no. 9-10, pp. 1389–1403. doi: 10.1016/S0531-5565(00)00181-9.   edoc
Briguet, A. and Ruegg, M. A. (2000) “The Ets transcription factor GABP is required for postsynaptic differentiation in vivo”, Journal of neuroscience. Society for Neuroscience, Vol. 20, H. 16, pp. 5989–5996. doi: 10.1523/JNEUROSCI.20-16-05989.2000 .   edoc
Meier, T. and Ruegg, M. A. (2000) “The Role of Dystroglycan and Its Ligands in Physiology and Disease”, News in physiological sciences. International Union of Physiological Sciences and the American Physiological Society, Vol. 15, pp. 255–259.   edoc
van der Putten, H., Wiederhold, K. H., Probst, A., Barbieri, S., Mistl, C., Danner, S., Kauffmann, S., Hofele, K., Spooren, W. P., Ruegg, M. A., Lin, S., Caroni, P., Sommer, B., Tolnay, M. and Bilbe, G. (2000) “Neuropathology in mice expressing human alpha-synuclein”, Journal of Neuroscience. Society for Neuroscience, 20(16), pp. 6021–6029.   edoc | Open Access
Halfter, W., Dong, S., Schurer, B., Osanger, A., Schneider, W., Ruegg, M. and Cole, G. J. (2000) “Composition, synthesis, and assembly of the embryonic chick retinal basal lamina”, Developmental biology. Academic Press, Vol. 220, H. 2, pp. 111–128. doi: 10.1006/dbio.2000.9649.   edoc
Kammerer, R. A., Schulthess, T., Landwehr, R., Schumacher, B., Lustig, A., Yurchenco, P. D., Ruegg, M. A., Engel, J. and Denzer, A. J. (1999) “Interaction of agrin with laminin requires a coiled-coil conformation of the agrin-binding site within the laminin gamma1 chain”, The EMBO Journal. Nature Publishing Group, 18(23), pp. 6762–6770. doi: 10.1093/emboj/18.23.6762.   edoc | Open Access
Groffen, A. J., Ruegg, M. A., Dijkman, H., van de Velden, T. J., Buskens, C. A., van den Born, J., Assmann, K. J., Monnens, L. A., Veerkamp, J. H. and van den Heuvel, L. P. (1998) “Agrin is a major heparan sulfate proteoglycan in the human glomerular basement membrane”, Journal of Histochemistry and Cytochemistry. Williams and Wilkins, 46(1), pp. 19–27. doi: 10.1177/002215549804600104.   edoc
Ruegg, M. A. and Bixby, J. L. (1998) “Agrin orchestrates synaptic differentiation at the vertebrate neuromuscular junction”, Trends in Neurosciences. Elsevier, 21(1), pp. 22–27. doi: 10.1016/S0166-2236(97)01154-5.   edoc
Sieb, J. P., Dorfler, P., Tzartos, S., Wewer, U. M., Ruegg, M. A., Meyer, D., Baumann, I., Lindemuth, R., Jakschik, J. and Ries, F. (1998) “Congenital myasthenic syndromes in two kinships with end-plate acetylcholine receptor and utrophin deficiency”, Neurology. American Academy of Neurology, 50(1), pp. 54–61. doi: 10.​1212/​WNL.​50.​1.​54.   edoc
Denzer, A. J., Schulthess, T., Fauser, C., Schumacher, B., Kammerer, R. A., Engel, J. and Ruegg, M. A. (1998) “Electron microscopic structure of agrin and mapping of its binding site in laminin-1”, The EMBO Journal. Nature Publishing Group, 17(2), pp. 335–343. doi: 10.1093/emboj/17.2.335.   edoc | Open Access
Gesemann, M., Brancaccio, A., Schumacher, B. and Ruegg, M. A. (1998) “Agrin is a high-affinity binding protein of dystroglycan in non-muscle tissue”, Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 273(1), pp. 600–605. doi: 10.1074/jbc.273.1.600.   edoc | Open Access
Nawrotzki, R., Loh, N. Y., Ruegg, M. A., Davies, K. E. and Blake, D. J. (1998) “Characterisation of alpha-dystrobrevin in muscle”, Journal of Cell Science. Company of Biologists, 111(17), pp. 2595–2605.   edoc | Open Access
Meier, T., Marangi, P. A., Moll, J., Hauser, D. M., Brenner, H. R. and Ruegg, M. A. (1998) “A minigene of neural agrin encoding the laminin-binding and acetylcholine receptor-aggregating domains is sufficient to induce postsynaptic differentiation in muscle fibres”, The European journal of neuroscience. Blackwell, Vol. 10, H. 10, pp. 3141–3152. doi: 10.1046/j.1460-9568.1998.00320.x.   edoc
Meier, T., Ruegg, M. A. and Wallace, B. G. (1998) “Muscle-specific agrin isoforms reduce phosphorylation of AChR gamma and delta subunits in cultured muscle cells”, Molecular and cellular neuroscience. Academic Press, Vol. 11, H. 4, pp. 206–216. doi: 10.1006/mcne.1998.0685.   edoc
Denzer, A. J., Brandenberger, R., Gesemann, M., Chiquet, M. and Ruegg, M. A. (1997) “Agrin binds to the nerve-muscle basal lamina via laminin”, The Journal of cell biology. Rockefeller University Press, Vol. 137, H. 3, pp. 671–683. doi: 10.1083/jcb.137.3.671.   edoc | Open Access
Meier, T., Hauser, D. M., Chiquet, M., Landmann, L., Ruegg, M. A. and Brenner, H. R. (1997) “Neural agrin induces ectopic postsynaptic specializations in innervated muscle fibers”, Journal of neuroscience. Society for Neuroscience, 17(17), pp. 6534–6544. doi: 10.1523/JNEUROSCI.17-17-06534.1997 .   edoc | Open Access
Campagna, J. A., Ruegg, M. A. and Bixby, J. L. (1997) “Evidence that agrin directly influences presynaptic differentiation at neuromuscular junctions in vitro”, The European journal of neuroscience. Blackwell, Vol. 9, H. 11, pp. 2269–2283. doi: 10.1111/j.1460-9568.1997.tb01645.x.   edoc
Denzer, A. J., Hauser, D. M., Gesemann, M. and Ruegg, M. A. (1997) “Synaptic differentiation : the role of agrin in the formation and maintenance of the neuromuscular junction”, Cell and Tissue Research. Springer, 290(2), pp. 357–365. doi: 10.1007/s004410050941.   edoc | Open Access
Meier, T., Gesemann, M., Cavalli, V., Ruegg, M. A. and Wallace, B. G. (1996) “AChR phosphorylation and aggregation induced by an agrin fragment that lacks the binding domain for alpha-dystroglycan”, The EMBO Journal. Nature Publishing Group, 15(11), pp. 2625–2631. doi: 10.1002/j.1460-2075.1996.tb00622.x.   edoc | Open Access
Ruegg, M. A. (1996) “Agrin, laminin beta 2 (s-laminin) and ARIA : their role in neuromuscular development”, Current Opinion in Neurobiology. Elsevier, Vol. 6, H. 1, pp. 97–103. doi: 10.1016/S0959-4388(96)80014-6.   edoc
Yamada, H., Denzer, A. J., Hori, H., Tanaka, T., Anderson, L. V., Fujita, S., Fukuta-Ohi, H., Shimizu, T., Ruegg, M. A. and Matsumura, K. (1996) “Dystroglycan is a dual receptor for agrin and laminin-2 in Schwann cell membrane”, Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 271(38), pp. 23418–23423. doi: 10.1074/jbc.271.38.23418.   edoc
Jones, G., Herczeg, A., Ruegg, M. A., Lichtsteiner, M., Kroger, S. and Brenner, H. R. (1996) “Substrate-bound agrin induces expression of acetylcholine receptor epsilon-subunit gene in cultured mammalian muscle cells”, Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 93(12), pp. 5985–5990. doi: 10.1073/pnas.93.12.5985.   edoc | Open Access
Gesemann, M., Cavalli, V., Denzer, A. J., Brancaccio, A., Schumacher, B. and Ruegg, M. A. (1996) “Alternative splicing of agrin alters its binding to heparin, dystroglycan, and the putative agrin receptor”, Neuron. Cell Press, Vol. 16, H. 4, pp. 755–767. doi: 10.1016/S0896-6273(00)80096-3.   edoc
Gesemann, M., Denzer, A. J. and Ruegg, M. A. (1995) “Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site”, The Journal of cell biology. Rockefeller University Press, Vol. 128, H. 4, pp. 625–636. doi: 10.1083/jcb.128.4.625.   edoc | Open Access
Denzer, A. J., Gesemann, M., Schumacher, B. and Ruegg, M. A. (1995) “An amino-terminal extension is required for the secretion of chick agrin and its binding to extracellular matrix”, The Journal of cell biology. Rockefeller University Press, Vol. 131, H. 6, pp. 1547–1560. doi: 10.1083/jcb.131.6.1547.   edoc | Open Access
Campagna, J. A., Ruegg, M. A. and Bixby, J. L. (1995) “Agrin is a differentiation-inducing ‘stop signal’ for motoneurons in vitro”, Neuron. Cell Press, Vol. 15, H. 6, pp. 1365–1374. doi: 10.1016/0896-6273(95)90014-4.   edoc
Brancaccio, A., Ruegg, M. A. and Engel, J. (1995) “Cloning and sequencing of mouse skeletal muscle alpha-dystroglycan”, Matrix biology. Elsevier Science, Vol. 14, H. 8, pp. 681–685. doi: 10.1016/S0945-053X(05)80032-0.   edoc
McMahan, U. J., Horton, S. E., Werle, M. J., Honig, L. S., Kroger, S., Ruegg, M. A. and Escher, G. (1992) “Agrin isoforms and their role in synaptogenesis”, Current opinion in cell biology. Elsevier, Vol. 4, H. 5, pp. 869–874. doi: 10.1016/0955-0674(92)90113-Q.   edoc
Ruegg, M. A., Tsim, K. W., Horton, S. E., Kroger, S., Escher, G., Gensch, E. M. and McMahan, U. J. (1992) “The agrin gene codes for a family of basal lamina proteins that differ in function and distribution”, Neuron. Cell Press, Vol. 8, H. 4, pp. 691–699. doi: 10.1016/0896-6273(92)90090-Z.   edoc
Tsim, K. W., Ruegg, M. A., Escher, G., Kroger, S. and McMahan, U. J. (1992) “cDNA that encodes active agrin”, Neuron. Cell Press, Vol. 8, H. 4, pp. 677–689. doi: 10.1016/0896-6273(92)90089-V.   edoc
Stoeckli, E. T., Kuhn, T. B., Duc, C. O., Ruegg, M. A. and Sonderegger, P. (1991) “The axonally secreted protein axonin-1 is a potent substratum for neurite growth”, Journal of Cell Biology. Rockefeller University Press, 112(3), pp. 449–455. doi: 10.1083/jcb.112.3.449.   edoc | Open Access
Stoeckli, E. T., Lemkin, P. F., Kuhn, T. B., Ruegg, M. A., Heller, M. and Sonderegger, P. (1989) “Identification of proteins secreted from axons of embryonic dorsal-root-ganglia neurons”, European Journal of Biochemistry. Blackwell, 180(2), pp. 249–258. doi: 10.1111/j.1432-1033.1989.tb14640.x.   edoc
Ruegg, M. A., Stoeckli, E. T., Kuhn, T. B., Heller, M., Zuellig, R. and Sonderegger, P. (1989) “Purification of axonin-1, a protein that is secreted from axons during neurogenesis”, The EMBO Journal. Nature Publishing Group, 8(1), pp. 55–63. doi: 10.1002/j.1460-2075.1989.tb03348.x.   edoc | Open Access