Publications

Smith, W. P. J., Vettiger, A., Winter, J., Ryser, T., Comstock, L. E., Basler, M. and Foster, K. R. (2020) “The evolution of the type VI secretion system as a disintegration weapon”, PLoS biology. Public Library of Science, 18(5), p. e3000720. doi: 10.1371/journal.pbio.3000720.   edoc | Open Access
García-Bayona, L., Coyne, M. J., Hantman, N., Montero-Llopis, P., Von, S. S., Ito, T., Malamy, M. H., Basler, M., Barquera, B. and Comstock, L. E. (2020) “Nanaerobic growth enables direct visualization of dynamic cellular processes in human gut symbionts”, Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences , 117(39), pp. 24484–24493. doi: 10.1073/pnas.2009556117.   edoc
Smith, W. P. J., Brodmann, M., Unterweger, D., Davit, Y., Comstock, L. E., Basler, M. and Foster, K. R. (2020) “The evolution of tit-for-tat in bacteria via the type VI secretion system”, Nature communications. Nature Research , 11(1), p. 5395. doi: 10.1038/s41467-020-19017-z.   edoc | Open Access
Schneider, J. P., Nazarov, S., Adaixo, R., Liuzzo, M., Ringel, P. D., Stahlberg, H. and Basler, M. (2019) “Diverse roles of TssA-like proteins in the assembly of bacterial type VI secretion systems”, The EMBO journal. EMBO Press, 38, p. e100825. doi: 10.15252/embj.2018100825.   edoc | Open Access
Lin, L., Ringel, P. D., Vettiger, A., Dürr, L. and Basler, M. (2019) “DNA Uptake upon T6SS-Dependent Prey Cell Lysis Induces SOS Response and Reduces Fitness of Acinetobacter baylyi”, Cell reports, 29(6), pp. 1633–1644.e4. doi: 10.1016/j.celrep.2019.09.083.   edoc
Agnetti, J., Seth-Smith, H. M. B., Ursich, S., Reist, J., Basler, M., Nickel, C., Bassetti, S., Ritz, N., Tschudin-Sutter, S. and Egli, A. (2019) “Clinical impact of the type VI secretion system on virulence of Campylobacter species during infection”, BMC infectious diseases. BMC, 19, p. 19:237. doi: 10.1186/s12879-019-3858-x.   edoc | Open Access
Lin, L., Lezan, E., Schmidt, A. and Basler, M. (2019) “Abundance of bacterial Type VI secretion system components measured by targeted proteomics”, Nature Communications. Nature Publishing Group, 10(1), p. 2584 (2019) . doi: 10.1038/s41467-019-10466-9.   edoc | Open Access
Wang, J., Brodmann, M. and Basler, M. (2019) “Assembly and Subcellular Localization of Bacterial Type VI Secretion Systems”, Annual Review of Microbiology. Annual Reviews, 73, pp. 621–638. doi: 10.1146/annurev-micro-020518-115420.   edoc | Open Access
Brackmann, M., Wang, J. and Basler, M. (2018) “Type VI secretion system sheath inter-subunit interactions modulate its contraction”, EMBO reports, 19(2), pp. 225–233. doi: 10.15252/embr.201744416.   edoc
Brodmann, M., Heilig, R., Broz, P. and Basler, M. (2018) “Mobilizable Plasmids for Tunable Gene Expression in Francisella novicida”, Frontiers in cellular and infection microbiology, 8, p. 284. doi: 10.3389/fcimb.2018.00284.   edoc
Nazarov, S., Schneider, J. P., Brackmann, M., Goldie, K. N., Stahlberg, H. and Basler, M. (2018) “Cryo-EM reconstruction of Type VI secretion system baseplate and sheath distal end”, The EMBO journal. EMBO Press, 37(4), p. e97103. doi: 10.15252/embj.201797103.   edoc | Open Access
Ringel, P. D., Hu, D. and Basler, M. (2017) “The Role of Type VI Secretion System Effectors in Target Cell Lysis and Subsequent Horizontal Gene Transfer”, Cell Reports. Cell Press, 21(13), pp. 3927–3940. doi: 10.1016/j.celrep.2017.12.020.   edoc | Open Access
Brackmann, M., Nazarov, S., Wang, J. and Basler, M. (2017) “Using Force to Punch Holes: Mechanics of Contractile Nanomachines”, Trends in Cell Biology. Elsevier, 27(9), pp. 623–632. doi: 10.1016/j.tcb.2017.05.003.   edoc
Brodmann, M., Dreier, R. F., Broz, P. and Basler, M. (2017) “Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape”, Nature Communications. Nature Publishing Group, 8, p. 15853. doi: 10.1038/ncomms15853.   edoc
Vettiger, A., Winter, J., Lin, L. and Basler, M. (2017) “The type VI secretion system sheath assembles at the end distal from the membrane anchor”, Nature Communications. Nature Publishing Group, 8, p. 16088. doi: 10.1038/ncomms16088.   edoc
Wang, J., Brackmann, M., Castaño-Díez, D., Kudryashev, M., Goldie, K. N., Maier, T., Stahlberg, H. and Basler, M. (2017) “Cryo-EM structure of the extended type VI secretion system sheath-tube complex”, Nature Microbiology. Nature Research, 2(11), pp. 1507–1512. doi: 10.1038/s41564-017-0020-7.   edoc
Vettiger, A. and Basler, M. (2016) “Type VI Secretion System Substrates Are Transferred and Reused among Sister Cells”, Cell. Cell Press, 167(1), pp. 99–110.e12. doi: 10.1016/j.cell.2016.08.023.   edoc
Schneider, J. P. and Basler, M. (2016) “Shedding light on biology of bacterial cells”, Philosophical Transactions of the Royal Society of London, Series B : Biological Sciences . Royal Society of London, 371(1707), p. 20150499. doi: 10.1098/rstb.2015.0499.   edoc
Nelson, M. B., Chase, A. B., Martiny, J. B. H., Stocker, R., Nguyen, J., Lloyd, K., Oshiro, R. T., Kearns, D. B., Schneider, J. P., Ringel, P. D., Basler, M., Olson, C. A., Vuong, H. E., Hsiao, E. Y., Roller, B. R. K., Ackermann, M., Smillie, C., Chien, D., Alm, E. and Jermy, A. J. (2016) “The Microbial Olympics 2016”, Nature Microbiology. Nature Publishing Group, 1(8), p. 16122. doi: 10.1038/nmicrobiol.2016.122.   edoc
Borenstein, D. B., Ringel, P., Basler, M. and Wingreen, N. S. (2015) “Established microbial colonies can survive type VI secretion assault”, PLoS Computational Biology. Library of Science, 11(10), p. e1004520. doi: 10.1371/journal.pcbi.1004520.   edoc | Open Access
Basler, M. (2015) “Type VI secretion system : secretion by a contractile nanomachine”, Philosophical Transactions : the Royal Society of London. Royal Society of London, Vol. 370, H. 1679, p. 20150021. doi: 10.1098/rstb.2015.0021.   edoc | Open Access
Wang, R. Y.-R., Kudryashev, M., Li, X., Egelman, E. H., Basler, M., Cheng, Y., Baker, D. and DiMaio, F. (2015) “De novo protein structure determination from near-atomic-resolution cryo-EM maps”, Nature methods. Nature Publishing Group, Vol. 12, H. 4 , S. 335–338. doi: 10.1038/nmeth.3287.   edoc
Kudryashev, M., Wang, R. Y.-R., Brackmann, M., Scherer, S., Maier, T., Baker, D., DiMaio, F., Stahlberg, H., Egelman, E. H. and Basler, M. (2015) “Structure of the Type VI Secretion System Contractile Sheath”, Cell. Cell Press, Vol. 160, H. 5, pp. 952–962. doi: 10.1016/j.cell.2015.01.037.   edoc
Basler, M., Ho, B. T. and Mekalanos, J. J. (2013) “Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions”, Cell. Cell Press, 152(4), pp. 884–894. doi: 10.1016/j.cell.2013.01.042.   edoc
Shneider, M. M., Buth, S. A., Ho, B. T., Basler, M., Mekalanos, J. J. and Leiman, P. G. (2013) “PAAR-repeat proteins sharpen and diversify the type VI secretion system spike”, Nature. Macmillan, 500(7462), pp. 350–353. doi: 10.1038/nature12453.   edoc
Ho, B. T., Basler, M. and Mekalanos, J. J. (2013) “Type 6 secretion system-mediated immunity to type 4 secretion system-mediated gene transfer”, Science. American Association for the Advancement of Science, 342(6155), pp. 250–253. doi: 10.1126/science.1243745.   edoc
Basler, M., Pilhofer, M., Henderson, G. P., Jensen, G. J. and Mekalanos, J. J. (2012) “Type VI secretion requires a dynamic contractile phage tail-like structure”, Nature. Macmillan, 483(7388), pp. 182–186. doi: 10.1038/nature10846.   edoc
Horváthová, L., Safaríková, L., Basler, M., Hrdy, I., Campo, N. B., Shin, J.-W., Huang, K.-Y., Huang, P.-J., Lin, R., Tang, P. and Tachezy, J. (2012) “Transcriptomic identification of iron-regulated and iron-independent gene copies within the heavily duplicated Trichomonas vaginalis genome”, Genome Biology and Evolution. Oxford University Press, 4(10), pp. 1017–1029. doi: 10.1093/gbe/evs078.   edoc
Basler, M. and Mekalanos, J. J. (2012) “Type 6 secretion dynamics within and between bacterial cells”, Science. American Association for the Advancement of Science, 337(6096), p. 815. doi: 10.1126/science.1222901.   edoc
Fiser, R., Masin, J., Bumba, L., Pospisilova, E., Fayolle, C., Basler, M., Sadilkova, L., Adkins, I., Kamanova, J., Cerny, J., Konopasek, I., Osicka, R., Leclerc, C. and Sebo, P. (2012) “Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores”, PLoS Pathogens. Public Library of Science, 8(4), p. e1002580. doi: 10.1371/journal.ppat.1002580.   edoc
Rao, J., Damron, F. H., Basler, M., Digiandomenico, A., Sherman, N. E., Fox, J. W., Mekalanos, J. J. and Goldberg, J. B. (2011) “Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient”, Frontiers in Microbiology. Frontiers Media, 2, p. 162. doi: 10.3389/fmicb.2011.00162.   edoc
Linhartová, I., Bumba, L., Mašín, J., Basler, M., Osička, R., Kamanová, J., Procházková, K., Adkins, I., Hejnová-Holubová, J., Sadílková, L., Morová, J. and Sebo, P. (2010) “RTX proteins: a highly diverse family secreted by a common mechanism”, FEMS Microbiology Reviews. Blackwell, 34(6), pp. 1076–1112. doi: 10.1111/j.1574-6976.2010.00231.x.   edoc | Open Access
Osickova, A., Masin, J., Fayolle, C., Krusek, J., Basler, M., Pospisilova, E., Leclerc, C., Osicka, R. and Sebo, P. (2010) “Adenylate cyclase toxin translocates across target cell membrane without forming a pore”, Molecular Microbiology. Blackwell, 75(6), pp. 1550–1562. doi: 10.1111/j.1365-2958.2010.07077.x.   edoc
Leiman, P. G., Basler, M., Ramagopal, U. A., Bonanno, J. B., Sauder, J. M., Pukatzki, S., Burley, S. K., Almo, S. C. and Mekalanos, J. J. (2009) “Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin”, Proceedings of the National Academy of Sciences. National Academy of Sciences, 106(11), pp. 4154–4159. doi: 10.1073/pnas.0813360106.   edoc
Vojtova-Vodolanova, J., Basler, M., Osicka, R., Knapp, O., Maier, E., Cerny, J., Benada, O., Benz, R. and Sebo, P. (2009) “Oligomerization is involved in pore formation by Bordetella adenylate cyclase toxin”, FASEB Journal. Federation of American Society of Experimental Biology , 23(9), pp. 2831–2843. doi: 10.1096/fj.09-131250.   edoc
Pánek, J., Bobek, J., Mikulík, K., Basler, M. and Vohradský, J. (2008) “Biocomputational prediction of small non-coding RNAs in Streptomyces”, BMC Genomics. BioMed Central, 9, p. 217. doi: 10.1186/1471-2164-9-217.   edoc
Frýdlová, I., Basler, M., Vasicová, P., Malcová, I. and Hasek, J. (2007) “Special type of pheromone-induced invasive growth in Saccharomyces cerevisiae”, Current Genetics. Springer, 52(2), pp. 87–95. doi: 10.1007/s00294-007-0141-2.   edoc
Fiser, R., Masín, J., Basler, M., Krusek, J., Spuláková, V., Konopásek, I. and Sebo, P. (2007) “Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities”, Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 282(5), pp. 2808–2820. doi: 10.1074/jbc.M609979200.   edoc
Basler, M., Knapp, O., Masin, J., Fiser, R., Maier, E., Benz, R., Sebo, P. and Osicka, R. (2007) “Segments crucial for membrane translocation and pore-forming activity of Bordetella adenylate cyclase toxin”, Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 282(17), pp. 12419–12429. doi: 10.1074/jbc.M611226200.   edoc
Sasková, L., Nováková, L., Basler, M. and Branny, P. (2007) “Eukaryotic-type serine/threonine protein kinase StkP is a global regulator of gene expression in Streptococcus pneumoniae”, Journal of Bacteriology. American Society for Microbiology, 189(11), pp. 4168–4179. doi: 10.1128/JB.01616-06.   edoc
Basler, M., Linhartová, I., Halada, P., Novotná, J., Bezousková, S., Osicka, R., Weiser, J., Vohradský, J. and Sebo, P. (2006) “The iron-regulated transcriptome and proteome of Neisseria meningitidis serogroup C”, Proteomics. Wiley, 6(23), pp. 6194–6206. doi: 10.1002/pmic.200600312.   edoc
Linhartova, I., Basler, M., Ichikawa, J., Pelicic, V., Osicka, R., Lory, S., Nassif, X. and Sebo, P. (2006) “Meningococcal adhesion suppresses proapoptotic gene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells”, FEMS Microbiology Letters. Oxford University Press, 263(1), pp. 109–118. doi: 10.1111/j.1574-6968.2006.00407.x.   edoc
Basler, M., Masin, J., Osicka, R. and Sebo, P. (2006) “Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytes”, Infection and Immunity. American Society for Microbiology, 74(4), pp. 2207–2214. doi: 10.1128/IAI.74.4.2207-2214.2006.   edoc
Masin, J., Basler, M., Knapp, O., El-Azami-El-Idrissi, M., Maier, E., Konopasek, I., Benz, R., Leclerc, C. and Sebo, P. (2005) “Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells”, Biochemistry. American Chemical Society, 44(38), pp. 12759–12766. doi: 10.1021/bi050459b.   edoc