Publications

Wagner-Hattler, L., Kiene, K., Bielicki, J., Pfister, M., Puchkov, M. and Huwyler, J. (2021) “High Acceptability of an Orally Dispersible Tablet Formulation by Children”, Children. MDPI, 8(3), p. 194. doi: 10.3390/children8030194.   edoc
Einfalt, T., Detampel, P., Häussinger, D., Casper, J., Meier, C., Puchkov, M. and Huwyler, J. (2021) “Hydroxychloroquine immediate release tablets: Formulation and evaluation of a solid dosage form”, ChemRxiv Preprint. doi: 10.26434/chemrxiv.14170508.v1.   edoc | Open Access
Schittny, A., Waldner, S., Duthaler, U., Vorobyev, A., Abramovich, R., Krähenbühl, S., Puchkov, M. and Huwyler, J. (2021) “Particle Forming Amorphous Solid Dispersions: A Mechanistic Randomized Pharmacokinetic Study in Humans”, pharmaceutics, 13(401), pp. 1–17. doi: 10.3390/pharmaceutics13030401.   
Schuster, J., Probst, C. E., Mahler, H.-C., Joerg, S., Huwyler, J. and Mathaes, R. (2021) “Assessing Particle Formation of Biotherapeutics in Biological Fluids”, Journal of Pharmaceutical Sciences, 110(4), pp. 1527–1532. doi: 10.1016/j.xphs.2020.12.038.   
Nicolle, L., Casper, J., Willimann, M., Journot, C. M. A., Detampel, P., Einfalt, T., Grisch-Chan, H. M., Thöny, B., Gerber-Lemaire, S. and Huwyler, J. (2021) “Development of Covalent Chitosan-Polyethylenimine Derivatives as Gene Delivery Vehicle: Synthesis, Characterization, and Evaluation”, International Journal of Molecular Sciences, 22(8), p. 3828. doi: 10.3390/ijms22083828.   
Schittny, A., Huwyler, J. and Puchkov, M. (2020) “Mechanisms of increased bioavailability through amorphous solid dispersions: a review”, Drug delivery. Taylor and Francis, 27(1), pp. 110–127. doi: 10.1080/10717544.2019.1704940.   edoc
Suenderhauf, C., Berger, B., Puchkov, M., Schmid, Y., Müller, S., Huwyler, J., Haschke, M., Krähenbühl, S. and Duthaler, U. (2020) “Pharmacokinetics and phenotyping properties of the ‘Basel’ phenotyping cocktail combination capsule in healthy male adults”, British journal of clinical pharmacology. Wiley, 86(2), pp. 352–361. doi: 10.1111/bcp.14157.   edoc
Häuser, C., Goldbach, P., Huwyler, J., Friess, W. and Allmendinger, A. (2020) “Excipients for Room Temperature Stable Freeze-Dried Monoclonal Antibody Formulations”, Journal of Pharmaceutical Sciences. Elsevier, 109(1), pp. 807–817. doi: 10.1016/j.xphs.2019.10.016.   edoc
Wagner-Hattler, L., Québatte, G., Keiser, J., Schoelkopf, J., Schlepütz, C. M., Huwyler, J. and Puchkov, M. (2020) “Study of drug particle distributions within mini-tables using synchrotron X-ray microtomography and superpixel image clustering”, International Journal of Pharmaceutics. Elsevier, 573, p. 118827. doi: 10.1016/j.ijpharm.2019.118827.   edoc
Dreckmann, T., Ludwig, I.-S., Boeuf, J., Lümkemann, J. and Huwyler, J. (2020) “Low Volume Aseptic Filling: Impact of Pump Systems on Shear Stress”, European Journal of Pharmaceutics and Biopharmaceutics. Elsevier, 147, pp. 10–18. doi: 10.1016/j.ejpb.2019.12.006.   edoc
Ehrsam, D., Sieber, S., Oufir, M., Porta, F., Hamburger, M., Huwyler, J. and Meyer zu Schwabedissen, H. E. (2020) “Design, Synthesis, and Characterization of a Paclitaxel Formulation Activated by Extracellular MMP9”, Bioconjugate Chemistry. American Chemical Society, 31(3), pp. 781–793. doi: 10.1021/acs.bioconjchem.9b00865.   edoc
Liu, J., Craciun, I., Belluati, A., Wu, D., Sieber, S., Einfalt, T., Witzigmann, D., Chami, M., Huwyler, J. and Palivan, C. G. (2020) “DNA-directed arrangement of soft synthetic compartments and their behavior in vitro and in vivo”, Nanoscale. Royal Society of Chemistry, 12(17), pp. 9786–9799. doi: 10.1039/d0nr00361a.   edoc | Open Access
Einfalt, T., Garni, M., Witzigmann, D., Sieber, S., Baltisberger, N., Huwyler, J., Meier, W. and Palivan, C. (2020) “Bioinspired Molecular Factories with Architecture and In Vivo Functionalities as Cell Mimics”, Advanced Science. Wiley, 7(4), p. 1901923. doi: 10.1002/advs.201901923.   edoc | Open Access
Schuster, J., Koulov, A., Mahler, H.-C., Detampel, P., Huwyler, J., Singh, S. and Mathaes, R. (2020) “In Vivo Stability of Therapeutic Proteins”, Pharmaceutical research, 37(2), p. 23. doi: 10.1007/s11095-019-2689-1.   
Farzan, M., Québatte, G., Strittmatter, K., Hilty, F. M., Schoelkopf, J., Huwyler, J. and Puchkov, M. (2020) “Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery”, pharmaceutics, 12(777), pp. 1–17. doi: 10.3390/pharmaceutics12080777.   
Vollrath, I., Mathaes, R., Sediq, A. S., Jere, D., Jörg, S., Huwyler, J. and Mahler, H.-C. (2020) “Subvisible Particulate Contamination in Cell Therapy Products-Can We Distinguish?”, Journal of pharmaceutical sciences, 109(1), pp. 216–219. doi: 10.1016/j.xphs.2019.09.002.   
Schuster, J., Koulov, A., Mahler, H.-C., Joerg, S., Huwyler, J., Schleicher, K., Detampel, P. and Mathaes, R. (2020) “Particle Analysis of Biotherapeutics in Human Serum Using Machine Learning”, Journal of Pharmaceutical Sciences, 109, pp. 1827–1832. doi: 10.1016/j.xphs.2020.02.015.   
Schmidt, A., Koulov, A., Huwyler, J., Mahler, H.-C. and Jahn, M. (2020) “Stabilizing Polysorbate 20 and 80 Against Oxidative Degradation”, Journal of Pharmaceutical Sciences, 109, pp. 1924–1932. doi: 10.1016/j.xphs.2020.03.003.   
Nikolaev, Y. A., Tutel’yan, A. V., Loiko, N. G., Buck, J., Sidorenko, S. V., Lazareva, I., Gostev, V., Manzen’yuk, O. Y., Shemyakin, I. G., Abramovich, R. A., Huwyler, J. and El’-Registan, G. I. (2020) “The use of 4-Hexylresorcinol as antibiotic adjuvant”, PloS one, 15(9), p. e0239147. doi: 10.1371/journal.pone.0239147.   
Sedighi, M., Rahimi, F., Shahbazi, M.-A., Rezayan, A. H., Kettiger, H., Einfalt, T., Huwyler, J. and Witzigmann, D. (2020) “Controlled Tyrosine Kinase Inhibitor Delivery to Liver Cancer Cells by Gate-Capped Mesoporous Silica Nanoparticles”, ACS Applied Bio Materials, 3, pp. 239–251. doi: 10.1021/acsabm.9b00772.   
Schuster, J., Mahler, H.-C., Koulov, A., Joerg, S., Racher, A., Huwyler, J., Detampel, P. and Mathaes, R. (2020) “Tracking the physical stability of fluorescent-labeled mAbs under physiologic invitro conditions in human serum and PBS”, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 152, pp. 193–201. doi: 10.1016/j.ejpb.2020.04.014.   
Cörek, E., Rodgers, G., Siegrist, S., Einfalt, T., Detampel, P., Schlepütz, C. M., Sieber, S., Fluder, P., Schulz, G., Unterweger, H., Alexiou, C., Müller, B., Puchkov, M. and Huwyler, J. (2020) “Shedding Light on Metal-Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution”, Small, 2000746, pp. 1–10. doi: 10.1002/smll.202000746.   
Jere, D., Sediq, A. S., Huwyler, J., Vollrath, I., Kardorff, M. and Mahler, H.-C. (2020) “Challenges for cell-based medicinal products from a pharmaceutical product perspective”, Journal of pharmaceutical sciences, 110(5), pp. 1900–1908. doi: 10.1016/j.xphs.2020.11.040.   
Yokoyama, R., Kimura, G., Huwyler, J., Hosoya, K.- ichi and Puchkov, M. (2020) “Impact of Insoluble Separation Layer Mechanical Properties on Disintegration and Dissolution Kinetics of Multilayer Tablets”, pharmaceutics, 12(495), p. 12060495. doi: 10.3390/pharmaceutics12060495.   
Grapentin, C., Müller, C., Kishore, R. S. K., Adler, M., ElBialy, I., Friess, W., Huwyler, J. and Khan, T. A. (2020) “Protein-Polydimethylsiloxane Particles in Liquid Vial Monoclonal Antibody Formulations Containing Poloxamer 188”, Journal of pharmaceutical sciences, 109, pp. 2393–2404. doi: 10.1016/j.xphs.2020.03.010.   
Buck, J., Mueller, D., Mettal, U., Ackermann, M., Grisch-Chan, H. M., Thöny, B., Zumbuehl, A., Huwyler, J. and Witzigmann, D. (2020) “Improvement of DNA Vector Delivery of DOTAP Lipoplexes by Short-Chain Aminolipids”, ACS publications, 5, pp. 24724–24732. doi: 10.1021/acsomega.0c03303.   
Schittny, A., Philipp-Bauer, S., Detampel, P., Huwyler, J. and Puchkov, M. (2020) “Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions”, Journal of controlled release, 320, pp. 214–225. doi: 10.1016/j.jconrel.2020.01.031.   
Schreiner, V., Durst, M., Arras, M., Detampel, P., Jirkof, P. and Huwyler, J. (2020) “Design and in vivo evaluation of a microparticulate depot formulation of buprenorphine for veterinary use”, Scientific Reports, 10, p. 17295. doi: 10.1038/s41598-020-74230-6.   
Dreckmann, T., Ludwig, I. S., Luemkemann, J., Ernst, A., Aipperspach, W., Dreckmann, T., Huwyler, J. and Troendle, J. (2020) “Assessment of sensor concepts for a 100% in-process control of low volume aseptic fill finish processes”, PDA journal of pharmaceutical science and technology, 74(6), pp. 660–673. doi: 10.5731/pdajpst.2019.011270.   
Bleher, S., Buck, J., Muhl, C., Sieber, S., Barnert, S., Witzigmann, D., Huwyler, J., Braz, M. and Süss, R. (2019) “Poly(Sarcosine) Surface Modification Imparts Stealth‐Like Properties to Liposomes”, Small. Wiley, 15(50), p. 1904716. doi: 10.1002/smll.201904716.   edoc
Sedighi, M., Sieber, S., Rahimi, F., Shahbazi, M.-A., Rezayan, A. H., Huwyler, J. and Witzigmann, D. (2019) “Rapid optimization of liposome characteristics using a combined microfluidics and design-of-experiment approach”, Drug delivery and translational research. Springer, 9(1), pp. 404–413. doi: 10.1007/s13346-018-0587-4.   edoc
Häuser, C., Goldbach, P., Huwyler, J., Fiess, W. and Allmendinger, A. (2019) “Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations”, Pharmaceutics. MDPI, 11(11), p. 616. doi: 10.3390/pharmaceutics11110616.   edoc
Kiene, K., Hayasi, N., Burhenne, J., Uchitomi, R., Sünderhauf, C., Schmid, Y., Haschke, M., Haefeli, W. E., Krähenbühl, S., Mikus, G., Inada, H. and Huwyler, J. (2019) “Microdosed midazolam for the determination of cytochrome P450 3A activity: Development and clinical evaluation of a buccal film”, European Journal of Pharmaceutical Sciences. Elsevier, 135, pp. 77–82. doi: 10.1016/j.ejps.2019.05.010.   edoc
Buck, J., Grossen, P., Cullis, P. R., Huwyler, J. and Witzigmann, D. (2019) “Lipid-Based DNA Therapeutics - Hallmarks of Non-Viral Gene Delivery”, ACS Nano. American Chemical Society, 13(4), pp. 3754–3782. doi: 10.1021/acsnano.8b07858.   edoc
Sieber, S., Grossen, P., Uhl, P., Detampel, P., Mier, W., Witzigmann, D. and Huwyler, J. (2019) “Zebrafish as a predictive screening model to assess macrophage clearance of liposomes in vivo ”, Nanomedicine: nanotechnology, biology and medicine. Elsevier, 17, pp. 82–93. doi: 10.1016/j.nano.2018.11.017.   edoc
Farzan, M., Roth, R., Québatte, G., Schoelkopf, J., Huwyler, J. and Puchkov, M. (2019) “Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry”, Pharmaceutics. MDPI, 11(1), p. 32- . doi: 10.3390/pharmaceutics11010032.   edoc
Häuser, C., Goldbach, P., Huwyler, J., Friess, W. and Allmendinger, A. (2019) “Impact of dextran on thermal properties, product quality attributes, and monoclonal antibody stability in freeze-dried formulations ”, European Journal of Pharmaceutics and Biopharmaceutics. Elsevier, 147, pp. 45–56. doi: 10.1016/j.ejpb.2019.12.010.   edoc
Witzigmann, D., Uhl, P., Sieber, S., Kaufman, C., Einfalt, T., Schöneweis, K., Grossen, P., Buck, J., Ni, Y., Schenk, S. H., Hussner, J., Meyer Zu Schwabedissen, H. E., Québatte, G., Mier, W., Urban, S. and Huwyler, J. (2019) “Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide”, eLife. eLife Sciences Publications, 8, p. e42276. doi: 10.7554/eLife.42276.   edoc
Sieber, S., Grossen, P., Bussmann, J., Campbell, F., Kros, A., Witzigmann, D. and Huwyler, J. (2019) “Zebrafish as a preclinical in vivo screening model for nanomedicines”, Advanced drug delivery reviews, (151-152), pp. 152–168. doi: 10.1016/j.addr.2019.01.001.   edoc
Meister, I., Assawasuwannakit, P., Vanobberghen, F., Penny, M. A., Odermatt, P., Sayasone, S., Huwyler, J., Tarning, J. and Keiser, J. (2019) “Pooled population pharmacokinetic analysis of tribendimidine for the treatment of Opisthorchis viverrini infections”, Antimicrobial Agents and Chemotherapy. American Society for Microbiology, 63(4), pp. e01391–18. doi: 10.1128/AAC.01391-18.   edoc | Open Access
Neodo, A., Schulz, J. D., Huwyler, J. and Keiser, J. (2019) “In vitro and In vivo drug-drug interaction study of the effects of ivermectin and oxantel pamoate on tribendimidine”, Antimicrobial agents and chemotherapy. American Society for Microbiology, 63(1), pp. e00762–18. doi: 10.1128/AAC.00762-18.   edoc
Ditter, D., Nieto, A., Mahler, H.-C., Roehl, H., Wahl, M., Huwyler, J. and Allmendinger, A. (2018) “Evaluation of Glass Delamination Risk in Pharmaceutical 10 mL/10R Vials”, Journal of Pharmaceutical Sciences, 107(2), pp. 624–637. doi: 10.1016/j.xphs.2017.09.016.   edoc
Yokoyama, R., Kimura, G., Schlepütz, C. M., Huwyler, J. and Puchkov, M. (2018) “Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces”, Pharmaceutics. MDPI, 10(4), p. 259. doi: 10.3390/pharmaceutics10040259.   edoc | Open Access
Sedighi, M., Rahimi, F., Rezayan, A. H., Shahbazi, M.-A., Witzigmann, D. and Huwyler, J. (2018) “Combined cerium oxide nanocapping and layer-by-layer coating of porous silicon containers for controlled drug release”, Journal of Materials Science. Springer, 53, pp. 14975–14988. doi: 10.1007/s10853-018-2731-4.   edoc
Campbell, F., Bos, F. L., Sieber, S., Arias-Alpizar, G., Koch, B. E., Huwyler, J., Kros, A. and Bussmann, J. (2018) “Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake”, ACS Nano. American Chemical Society, 12(3), pp. 2138–2150. doi: 10.1021/acsnano.7b06995.   edoc
Wimmersberger, D., Coulibaly, J. T., Schulz, J. D., Puchkov, M., Huwyler, J., N’Gbesso, Y., Hattendorf, J. and Keiser, J. (2018) “Efficacy and Safety of Ivermectin Against Trichuris trichiura in Preschool-aged and School-aged Children: A Randomized Controlled Dose-finding Trial”, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 67(8), pp. 1247–1255. doi: 10.1093/cid/ciy246.   edoc
Ditter, D., Mahler, H.-C., Gohlke, L., Nieto, A., Roehl, H., Huwyler, J., Wahl, M. and Allmendinger, A. (2018) “Impact of Vial Washing and Depyrogenation on Surface Properties and Delamination Risk of Glass Vials”, Pharmaceutical research, 35(7), p. 146. doi: 10.1007/s11095-018-2421-6.   edoc
Boll, B., Josse, L., Heubach, A., Hochenauer, S., Finkler, C., Huwyler, J. and Koulov, A. V. (2018) “Impact of non-ideal analyte behavior on the separation of protein aggregates by asymmetric flow field-flow fractionation”, Journal of Separation Science, 2018; 41, pp. 2854–2864. doi: 10.1002/jssc.201701457.   edoc
Siegrist, S., Cörek, E., Detampel, P., Sandström, J., Wick, P. and Huwyler, J. (2018) “Preclinical hazard evaluation strategy for nanomedicines”, Nanotoxicology, pp. 1–27. doi: 10.1080/17435390.2018.1505000.   edoc
Haeuser, C., Goldbach, P., Huwyler, J., Friess, W. and Allmendinger, A. (2018) “Imaging Techniques to Characterize Cake Appearance of Freeze-Dried Products”, Journal of pharmaceutical sciences, 107(11), pp. 2810–2822. doi: 10.1016/j.xphs.2018.06.025.   edoc
Wagner-Hattler, L., Schoelkopf, J., Huwyler, J. and Puchkov, M. (2018) “Stability investigation of FCC-based tablets for oral suspension with caffeine and oxantel pamoate as model drugs”, Drug development and industrial pharmacy, pp. 1–9. doi: 10.1080/03639045.2018.1529784.   edoc
Schittny, A., Ogawa, H., Huwyler, J. and Puchkov, M. (2018) “A Combined Mathematical Model Linking the Formation of Amorphous Solid Dispersions with Hot-Melt-Extrusion Process Parameters”, European Journal of Pharmaceutics and Biopharmaceutics. Elsevier, 132, pp. 127–145. doi: 10.1016/j.ejpb.2018.09.011.   edoc
Mech, A., Rasmussen, K., Jantunen, P., Aicher, L., Alessandrelli, M., Bernauer, U., Bleeker, E. A. J., Bouillard, J., Di Prospero Fanghella, P., Draisci, R., Dusinska, M., Encheva, G., Flament, G., Haase, A., Handzhiyski, Y., Herzberg, F., Huwyler, J., Jacobsen, N. R., Jeliazkov, V., Jeliazkova, N., Nymark, P., Grafström, R., Oomen, A. G., Polci, M. L., Riebeling, C., Sandström, J., Shivachev, B., Stateva, S., Tanasescu, S., Tsekovska, R., Wallin, H., Wilks, M. F., Zellmer, S. and Apostolova, M. D. (2018) “Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation”, Nanotoxicology. Taylor & Francis, pp. 1–23. doi: 10.1080/17435390.2018.1513092.   edoc | Open Access
Moser, W., Sayasone, S., Xayavong, S., Bounheuang, B., Puchkov, M., Huwyler, J., Hattendorf, J. and Keiser, J. (2018) “Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate against hookworm infections in school-aged children in Laos : a randomised, single-blind trial”, The Lancet infectious diseases. Elsevier, 18(7), pp. 729–737. doi: 10.1016/S1473-3099(18)30220-2.   edoc
Barda, B., Ame, S. M., Ali, S. M., Albonico, M., Puchkov, M., Huwyler, J., Hattendorf, J. and Keiser, J. (2018) “Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections : a randomised, non-inferiority, single-blind trial”, The Lancet infectious diseases. Elsevier, 18(8), pp. 864–873. doi: 10.1016/S1473-3099(18)30233-0.   edoc
Roth, R., Schoelkopf, J., Huwyler, J. and Puchkov, M. (2018) “Functionalized calcium carbonate microparticles for the delivery of proteins”., European Journal of Pharmaceutics and Biopharmaceutics, 122, pp. 96–103. doi: 10.1016/j.ejpb.2017.10.012.   edoc
Ditter, D., Mahler, H.-C., Roehl, H., Wahl, M., Huwyler, J., Nieto, A. and Allmendinger, A. (2018) “Characterization of surface properties of glass vials used as primary packaging material for parenterals”, European Journal of Pharmaceutics and Biopharmaceutics. Elsevier, 125, pp. 58–67. doi: 10.1016/j.ejpb.2017.12.018.   edoc
Einfalt, T., Witzigmann, D., Edlinger, C., Sieber, S., Goers, R. ., Najer, A., Spulber, M., Onaca-Fischer, O., Huwyler, J. and Palivan, C. G. (2018) “Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment”, Nature Communications. Nature Publishing Group, 9, p. 1127. doi: 10.1038/s41467-018-03560-x.   edoc | Open Access
Barda, B., Sayasone, S., Phongluxa, K., Xayavong, S., Keoduangsy, K., Odermatt, P., Puchkov, M., Huwyler, J., Hattendorf, J. and Keiser, J. (2017) “Efficacy of Moxidectin Versus Ivermectin Against Strongyloides stercoralis Infections: A Randomized, Controlled Noninferiority Trial”, Clinical Infectious Diseases. Oxford University Press, 65(2), pp. 276–281. doi: 10.1093/cid/cix278.   edoc
Thalmann, P., Bikis, C., Schulz, G., Paleo, P., Mirone, A., Rack, A., Siegrist, S., Cörek, E., Huwyler, J. and Müller, B. (2017) “Conference Proceedings: Removing ring artefacts from synchrotron radiation-based hard x-ray tomography data”, Proceedings of SPIE. Society of Photo-optical Instrumentation Engineers (SPIE), 10391, pp. 1039114–1039111. doi: 10.1117/12.2274236.   edoc
Wagner-Hattler, L., Wyss, K., Schoelkopf, J., Huwyler, J. and Puchkov, M. (2017) “In vitro characterization and mouthfeel study of functionalized calcium carbonate in orally disintegrating tablets”, International Journal of Pharmaceutics. Elsevier, 534, pp. 50–59. doi: 10.1016/j.ijpharm.2017.10.009.   edoc
Grossen, P., Witzigmann, D., Sieber, S. and Huwyler, J. (2017) “PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application”, Journal of Controlled Release. Elsevier, 260, pp. 46–60. doi: 10.1016/j.jconrel.2017.05.028.   edoc
Kiene, K., Porta, F., Topacogullari, B., Detampel, P. and Huwyler, J. (2017) “Self-assembling chitosan hydrogel: A drug-delivery device enabling the sustained release of proteins”, Journal of Applied Polymer Science. Wiley, 135(1), p. 45638. doi: 10.1002/app.45638.   edoc
Sieber, S., Grossen, P., Detampel, P., Siegfried, S., Witzigmann, D. and Huwyler, J. (2017) “Zebrafish as an early stage screening tool to study the systemic circulation of nanoparticulate drug delivery systems in vivo”, Journal of Controlled Release. Elsevier, 264, pp. 180–191. doi: 10.1016/j.jconrel.2017.08.023.   edoc
Moser, W., Coulibaly, J., Ali, S. M., Ame, S. M., Amour, A. K., Yapi, R. B., Albonico, M., Puchkov, M., Huwyler, J., Hattendorf, J. and Keiser, J. (2017) “Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d’Ivoire: a randomised, controlled, single-blinded, non-inferiority trial”, Lancet Infectious Diseases. Elsevier, 17(11), pp. 1162–1171. doi: 10.1016/S1473-3099(17)30487-5.   edoc
Kiene, K., Schenk, S. H., Porta, F., Ernst, A., Witzigmann, D., Grossen, P. and Huwyler, J. (2017) “PDMS-b-PMOXA polymersomes for hepatocyte targeting and assessment of toxicity”, European Journal of Pharmaceutics and Biopharmaceutics. Elsevier, 119, pp. 322–332. doi: 10.1016/j.ejpb.2017.07.002.   edoc
Uhl, P., Pantze, S., Storck, P., Parmentier, J., Witzigmann, D., Hofhaus, G., Huwyler, J., Mier, W. and Fricker, G. (2017) “Oral delivery of vancomycin by tetraether lipid liposomes”, European Journal of Pharmaceutical Sciences. Elsevier, 108, pp. 111–118. doi: 10.1016/j.ejps.2017.07.013.   edoc
Boll, B., Bessa, J., Folzer, E., RÍos Quiroz, A., Schmidt, R., Bulau, P., Finkler, C., Mahler, H.-C., Huwyler, J., Iglesias, A. and Koulov, A. V. (2017) “Extensive Chemical Modifications in the Primary Protein Structure of IgG1 Subvisible Particles Are Necessary for Breaking Immune Tolerance”, Molecular Pharmaceutics. American Chemical Society, 14(4), pp. 1292–1299. doi: 10.1021/acs.molpharmaceut.6b00816.   edoc
Siegrist, S., Kettiger, H., Fasler-Kan, E. and Huwyler, J. (2017) “Selective stimulation of the JAK/ ST AT signaling pathway by silica nanoparticles in human endothelial cells”, Toxicology in Vitro. Elsevier, 42, pp. 308–318. doi: 10.1016/j.tiv.2017.05.002.   edoc
Riede, J., Camenisch, G., Huwyler, J. and Poller, B. (2017) “Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations”, Journal of Pharmaceutical Sciences. Elsevier, 106(9), pp. 2805–2814. doi: 10.1016/j.xphs.2017.03.025.   edoc
Wagner-Hattler, L., Schoelkopf, J., Huwyler, J. and Puchkov, M. (2017) “Characterization of new Functionalized Calcium Carbonate-Polycaprolactone Composite Material for Application in Geometry-constrained Drug Release Formulation Development”, Drug Development and Industrial Pharmacy. Taylor & Francis, 43(10), pp. 1669–1676. doi: 10.1080/03639045.2017.1328435.   edoc
Riede, J., Poller, B., Huwyler, J. and Camenisch, G. (2017) “Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations”, Drug Metabolism and Disposition. American Society for Pharmacology and Experimental Therapeutics, 45(5), pp. 523–532. doi: 10.1124/dmd.116.074179.   edoc
Sieber, S., Siegrist, S., Schwarz, S., Porta, F., Schenk, S. H. and Huwyler, J. (2017) “Immobilization of Enzymes on PLGA Sub-Micrometer Particles by Crosslinked Layer-by-Layer Deposition”, Macromolecular Bioscience. Wiley, 17(8), p. 1700015. doi: 10.1002/mabi.201700015.   edoc
Kettiger, H., Québatte, G., Perrone, B. and Huwyler, J. (2016) “Interactions between silica nanoparticles and phospholipid membranes”, Biochimica et biophysica acta. Elsevier, 1858(9), pp. 2163–2170. doi: 10.1016/j.bbamem.2016.06.023.   edoc
Buck, J., Huwyler, J., Kühl, P. and Dischinger, A. (2016) “Pediatric Dispersible Tablets: a Modular Approach for Rapid Prototyping”, Pharmaceutical research. Plenum Press, 33(8), pp. 2043–2055. doi: 10.1007/s11095-016-1946-9.   edoc
Preisig, D., Roth, R., Tognola, S., Varum, F. J. O., Bravo, R., Cetinkaya, Y., Huwyler, J. and Puchkov, M. (2016) “Mucoadhesive microparticles for local treatment of gastrointestinal diseases”, European journal of pharmaceutics and biopharmaceutics. Elsevier, 105, pp. 156–165. doi: 10.1016/j.ejpb.2016.06.009.   edoc
Gliesche, D. G., Hussner, J., Witzigmann, D., Porta, F., Glatter, T., Schmidt, A., Huwyler, J. and Meyer Zu Schwabedissen, H. E. (2016) “Secreted Matrix Metalloproteinase-9 of Proliferating Smooth Muscle Cells as a Trigger for Drug Release from Stent Surface Polymers in Coronary Arteries”, Molecular Pharmaceutics. American Chemical Society, 13(7), pp. 2290–2300. doi: 10.1021/acs.molpharmaceut.6b00033.   edoc
Witzigmann, D., Quagliata, L., Schenk, S. H., Quintavalle, C., Terracciano, L. M. and Huwyler, J. (2016) “Variable asialoglycoprotein-receptor 1 expression in liver disease: Implications for therapeutic intervention”, Hepatology research . Blackwell, 46(7), pp. 686–696. doi: 10.1111/hepr.12599.   edoc
Eberle, V. A., Häring, A., Schoelkopf, J., Gane, P. A. C., Huwyler, J. and Puchkov, M. (2016) “In silico and in vitro methods to optimize the performance of experimental gastroretentive floating mini-tablets”, Drug development and industrial pharmacy. Informa Healthcare, 42(5), pp. 808–817. doi: 10.3109/03639045.2015.1078350.   edoc
Riede, J., Poller, B., Umehara, K.- ichi, Huwyler, J. and Camenisch, G. (2016) “New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data”, European journal of pharmaceutical sciences. Elsevier, 86, pp. 96–102. doi: 10.1016/j.ejps.2016.02.022.   edoc
Ríos Quiroz, A., Lamerz, J., De Cunha, T., Boillon, A., Adler, M., Finkler, C., Huwyler, J., Schmidt, R., Mahler, H.-C. and Koulov, A. V. (2016) “Factors Governing the Precision of Subvisible Particle Measurement Methods - A Case Study with a Low-Concentration Therapeutic Protein Product in a Prefilled Syringe”, Pharmaceutical research. Springer, 33(2), pp. 450–461. doi: 10.1007/s11095-015-1801-4.   edoc
Mathaes, R., Mahler, H.-C., Buettiker, J.-P., Roehl, H., Lam, P., Brown, H., Luemkemann, J., Adler, M., Huwyler, J., Streubel, A. and Mohl, S. (2016) “The pharmaceutical vial capping process; Container closure systems, capping equipment, regulatory framework, and seal quality tests”, European journal of pharmaceutics and biopharmaceutics. Elsevier, 99, pp. 54–64. doi: 10.1016/j.ejpb.2015.11.016.   edoc
Werk, T., Ludwig, I. S., Mahler, H.-C., Luemkemann, J., Huwyler, J. and Hafner, M. (2016) “The Effect of Formulation, Process, and Method Variables on the Reconstitution Time in Dual Chamber Syringes”, PDA Journal of Pharmaceutical Science and Technology. Parenteral Drug Association (PDA), 70(6), pp. 508–522. doi: 10.5731/pdajpst.2016.006387.   edoc
Werk, T., Mahler, H.-C., Ludwig, I. S., Luemkemann, J., Huwyler, J. and Hafner, M. (2016) “A Method to Determine the Kinetics of Sulute Mixing in Liquid/Liquid Formulation Dual-Chamber Syringes”, PDA Journal of Pharmaceutical Science and Technology. Parenteral Drug Association (PDA), 71(1), pp. 2–10. doi: 10.5731/pdajpst.2016.006601.   edoc
Werk, T., Ludwig, I. S., Luemkemann, J., Huwyler, J., Mahler, H. .-C., Haeuser, C. R. and Hafner, M. (2016) “New Processes for Freeze-Drying in Dual-Chamber Systems”, PDA Journal of Pharmaceutical Science and Technology. Parenteral Drug Association (PDA), 70(3), pp. 191–207. doi: 10.5731/pdajpst.2015.006155.   edoc
Mathaes, R., Mahler, H.-C., Vorgrimler, L., Steinberg, H., Dreher, S., Roggo, Y., Nieto, A., Brwon, H., Roehl, H., Adler, M., Luemkemann, J., Huwyler, J., Lam, P., Stauch, O., Mohl, S. and Streubel, A. (2016) “The Pharmaceutical Capping Process - Correlation between Residual Seal Force, Torque Moment, and Flip-off Removal Force”, PDA Journal of Pharmaceutical Science and Technology. Parenteral Drug Association (PDA), 70(3), pp. 218–229. doi: 10.5731/pdajpst.2015.006106.   edoc
Mathaes, R., Mahler, H.-C., Roggo, Y., Huwyler, J., Eder, J., Fritsch, K., Posset, T., Mohl, S. and Streubel, A. (2016) “Influence of Different Container Closure Systems and Capping Process Parameters on Product Quality and Container Closure Integrity (CCI) in GMP Drug Product Manufacturing”, PDA Journal of Pharmaceutical Science and Technology. Parenteral Drug Association, 70(2), pp. 109–119. doi: 10.5731/pdajpst.2015.005918.   edoc
Witzigmann, D., Detampel, P., Porta, F. and Huwyler, J. (2016) “Isolation of Multiantennary N-Glycans from Glycoproteins for Hepatocyte Specific Targeting via the Asialoglycoprotein Receptor”, RSC Advances. Royal Society of Chemistry, 6, pp. 97636–97640. doi: 10.1039/C6RA18297F.   edoc
Duthaler, U., Sayasone, S., Vanobbergen, F., Penny, M. A., Odermatt, P., Huwyler, J. and Keiser, J. (2016) “Single-ascending-Ddse pharmacokinetic study of tribendimidine in opisthorchis viverrini-infected patients”, Antimicrobial Agents and Chemotherapy. American Society for Microbiology, 60(10), pp. 5705–5715. doi: 10.1128/AAC.00992-16.   edoc
Leonidova, A., Vargas, M., Huwyler, J. and Keiser, J. (2016) “Pharmacokinetics of the Antischistosomal Lead Ozonide OZ418 in Uninfected Mice Determined by Liquid Chromatography-Tandem Mass Spectrometry”, Antimicrobial Agents and Chemotherapy. American Society for Microbiology, 60(12), pp. 7364–7371. doi: 10.1128/AAC.02394-15.   edoc
Camblin, M., Berger, B., Haschke, M., Krähenbühl, S., Huwyler, J. and Puchkov, M. (2016) “CombiCap: A novel drug formulation for the basel phenotyping cocktail”, International Journal of Pharmaceutics. Elsevier, 512(1), pp. 253–261. doi: 10.1016/j.ijpharm.2016.08.043.   edoc
Grossen, P., Québatte, G., Witzigmann, D., Prescianotto-Baschong, C., Dieu, L.-H. and Huwyler, J. (2016) “Functionalized Solid-Sphere PEG-b-PCL Nanoparticles to Target Brain Capillary Endothelial Cells In Vitro”, Journal of Nanomaterials. Hindawi, 2016, p. 7818501. doi: 10.1155/2016/7818501.   edoc
Mathaes, R., Mahler, H.-C., Roggo, Y., Ovadia, R., Lam, P., Stauch, O., Vogt, M., Roehl, H., Huwyler, J., Mohl, S. and Streubel, A. (2016) “Impact of Vial Capping on Residual Seal Force and Container Closure Integrity”, PDA Journal of Pharmaceutical Science and Technology. Parenteral Drug Association (PDA), 70(1), pp. 12–29. doi: 10.5731/pdajpst.2015.005876.   edoc
Barda, B., Coulibaly, J. T., Puchkov, M., Huwyler, J., Hattendorf, J. and Keiser, J. (2016) “Efficacy and safety of moxidectin, synriam, synriam-praziquantel versus praziquantel against schistosoma haematobium and S. mansoni infections: a randomized, exploratory phase 2 trial”, PLoS Neglected Tropical Diseases. Public Library of Science, 10(9), p. e0005008. doi: 10.1371/journal.pntd.0005008.   edoc | Open Access
Meister, I., Leonidova, A., Kovač, J., Duthaler, U., Keiser, J. and Huwyler, J. (2016) “Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots”, Journal of pharmaceutical and biomedical analysis. Elsevier, 118, pp. 81–88. doi: 10.1016/j.jpba.2015.10.011.   edoc
Kettiger, H., Karaman, D. S., Schiesser, L., Rosenholm, J. M. and Huwyler, J. (2015) “Comparative safety evaluation of silica-based particles”, Toxicology in vitro. Elsevier, 30(1), pp. 355–363. doi: 10.1016/j.tiv.2015.09.030.   edoc
Folzer, E., Khan, T., Schmidt, R., Finkler, C., Huwyler, J., Mahler, H.-C. and Koulov, A. V. (2015) “Determination of the Density of Protein Particles Using a Suspended Microchannel Resonator”, Journal of pharmaceutical sciences. American Pharmaceutical Association, 104(12), pp. 4034–4040. doi: 10.1002/jps.24635.   edoc
Boll, B., Folzer, E., Finkler, C., Huwyler, J., Mahler, H.-C., Schmidt, R. and Koulov, A. V. (2015) “Comparative Evaluation of Two Methods for Preparative Fractionation of Proteinaceous Subvisible Particles-Differential Centrifugation and FACS”, Pharmaceutical research. Springer, 32(12), pp. 3952–3964. doi: 10.1007/s11095-015-1755-6.   edoc
Allmendinger, A., Mueller, R., Huwyler, J., Mahler, H.-C. and Fischer, S. (2015) “Sterile Filtration of Highly Concentrated Protein Formulations: Impact of Protein Concentration, Formulation Composition, and Filter Material”, Journal of pharmaceutical sciences. American Pharmaceutical Association, 104(10), pp. 3319–3329. doi: 10.1002/jps.24561.   edoc
Werk, T., Huwyler, J., Hafner, M., Luemkemann, J. and Mahler, H.-C. (2015) “An Impedance-Based Method to Determine Reconstitution Time for Freeze-Dried Pharmaceuticals”, Journal of pharmaceutical sciences. American Pharmaceutical Association, 104(9), pp. 2948–2955. doi: 10.1002/jps.24443.   edoc
Folzer, E., Diepold, K., Bomans, K., Finkler, C., Schmidt, R., Bulau, P., Huwyler, J., Mahler, H.-C. and Koulov, A. V. (2015) “Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule”, Journal of pharmaceutical sciences. American Pharmaceutical Association, 104(9), pp. 2824–2831. doi: 10.1002/jps.24509.   edoc
Kunze, A., Poller, B., Huwyler, J. and Camenisch, G. (2015) “Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins”, Drug Metabolism and Personalized Therapy. de Gruyter, 30(3), pp. 175–188. doi: 10.1515/dmdi-2015-0003.   edoc
Allmendinger, A., Mueller, R., Schwarb, E., Chipperfield, M., Huwyler, J., Mahler, H.-C. and Fischer, S. (2015) “Measuring Tissue Back-Pressure - In Vivo Injection Forces During Subcutaneous Injection”, Pharmaceutical research. Plenum Press, 32(7), pp. 2229–2240. doi: 10.1007/s11095-014-1611-0.   edoc
Preisig, D., Weingartner, M., Varum, F. J. O., Bravo, R., Alles, R., Huwyler, J. and Puchkov, M. (2015) “Marker-ion analysis for quantification of mucoadhesivity of microparticles in particle-retention assays”, International journal of pharmaceutics. Elsevier, 487(1-2), pp. 157–166. doi: 10.1016/j.ijpharm.2015.04.020.   edoc
Seeland, S., Kettiger, H., Murphy, M., Treiber, A., Giller, J., Kiss, A., Sube, R., Krähenbühl, S., Hafner, M. and Huwyler, J. (2015) “ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor”, Pharmacology Research & Perspecitves. Wiley, 3(2), p. e00123. doi: 10.1002/prp2.123.   edoc
Camenisch, G., Riede, J., Kunze, A., Huwyler, J., Poller, B. and Umehara, K. (2015) “The extended clearance model and its use for the interpretation of hepatobiliary elimination data”, ADMET & DMPK. International Association of Physical Chemists, 3(1), pp. 1–14. doi: 10.5599/admet.3.1.144.   edoc
Wicki, A., Witzigmann, D., Balasubramanian, V. and Huwyler, J. (2015) “Nanomedicine in cancer therapy : challenges, opportunities, and clinical applications”, Journal of controlled release. Elsevier, 200, pp. 138–157. doi: 10.1016/j.jconrel.2014.12.030.   edoc
Jaeschke, G., Kolczewski, S., Spooren, W., Vieira, E., Bitter-Stoll, N., Boissin, P., Borroni, E., Büttelmann, B., Ceccarelli, S., Clemann, N., David, B., Funk, C., Guba, W., Harrison, A., Hartung, T., Honer, M., Huwyler, J., Kuratli, M., Niederhauser, U., Pähler, A., Peters, J.-U., Petersen, A., Prinssen, E., Ricci, A., Rueher, D., Rueher, M., Schneider, M., Spurr, P., Stoll, T., Tännler, D., Wichmann, J., Porter, R. H., Wettstein, J. G. and Lindemann, L. (2015) “Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases”, Journal of medicinal chemistry. American Chemical Society, 58(3), pp. 1358–1371. doi: 10.1021/jm501642c.   edoc
Studer, C., Aicher, L., Gasic, B., von Goetz, N., Hoet, P., Huwyler, J., Kägi, R., Kase, R., Kobe, A., Nowack, B., Rothen-Rutishauser, B., Schirmer, K., Schneider, G., Vermeissen, E., Wick, P. and Walser, T. (2015) “Scientific Basis for Regulatory Decision-Making of Nanomaterials; Report on the Workshop, 20-21 January 2014; Center of Applied Ecotoxicology, Dübendorf”, in Chima (ed.) Scientific Basis for Regulatory Decision-Making of Nanomaterials. Switzerland: Chima, pp. 52–56. doi: 10.2533/chimia.2015.52.   edoc
Eberle, V. A., Donzelli, M., Alles, R., Puchkov, M. and Huwyler, J. (2015) “In Vivo Evaluation of a Gastroretentive Drug Delivery System Based on Enteric-Coated Floating Tablets”, Clinical Research: Open Access. SciForschen, 1.2. doi: 10.16966/2469-6714.105.   edoc | Open Access
Moser, W., Ali, S. M., Ame, S. M., Speich, B., Puchkov, M., Huwyler, J., Albonico, M., Hattendorf, J. and Keiser, J. (2015) “Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study”, The Lancet infectious diseases. Elsevier, 16(1), pp. 53–60. doi: 10.1016/S1473-3099(15)00271-6.   edoc
Witzigmann, D., Sieber, S., Porta, F., Grossen, P., Bieri, A., Strelnikova, N., Pfohl, T., Prescianotto-Baschong, C. and Huwyler, J. (2015) “Formation of lipid and polymer based gold nanohybrids using a nanoreactor approach”, RSC Advances. Royal Society of Chemistry, 5(91), pp. 74320–74328. doi: 10.1039/C5RA13967H .   edoc | Open Access
Duthaler, U., Keiser, J. and Huwyler, J. (2015) “LC-MS/MS method for the determination of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and dried blood spots”, Journal of pharmaceutical and biomedical analysis. Elsevier, 105, pp. 163–173. doi: 10.1016/j.jpba.2014.12.006.   edoc
Witzigmann, D., Wu, D., Schenk, S. H., Balasubramanian, V., Meier, W. and Huwyler, J. (2015) “Biocompatible Polymer-Peptide Hybrid-Based DNA Nanoparticles for Gene Delivery”, ACS applied materials & interfaces, 7(19), pp. 10446–10456. doi: 10.1021/acsami.5b01684.   edoc
Ríos Quiroz, A., Québatte, G., Stump, F., Finkler, C., Huwyler, J., Schmidt, R., Mahler, H.-C., Koulov, A. V. and Adler, M. (2015) “Measuring Subvisible Particles in Protein Formulations Using a Modified Light Obscuration Sensor with Improved Detection Capabilities”, Analytical chemistry. American Chemical Society, Vol. 87, H. 12, pp. 6119–6124. doi: 10.1021/acs.analchem.5b00688.   edoc
Mueller, B., Hieber, S. E., Zumbuehl, A., Walter, M. A., Huwyler, J., Pfohl, T. and Cattin, P. C. (2015) “Translational Medicine: Nanoscience and Nanotechnology to Improve Patient Care”, in Van de Voorde, M., Werner, M., and Fecht, H.-J. (eds.) The Nano-Micro Interface: Bridging the Micro and Nano Worlds. Weinheim: Wiley-VCH, pp. 291–309.   edoc
Keiser, J. and [et al.] (2015) “Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infection : a four-arm, randomised controlled trial”, The Lancet infectious diseases. Elsevier, Vol. 15, H. 3, pp. 277–284. doi: 10.1016/S1473-3099(14)71050-3.   edoc
Stirnimann, T., Atria, S., Schoelkopf, J., Gane, P. A., Alles, R., Huwyler, J. and Puchkov, M. (2014) “Compaction of functionalized calcium carbonate, a porous and crystalline microparticulate material with a lamellar surface”, International journal of pharmaceutics. Elsevier, Vol. 466, H. 1-2 , S. 266–275. doi: 10.1016/j.ijpharm.2014.03.027.   edoc
Allmendinger, A., Dieu, L. H., Fischer, S., Mueller, R., Mahler, H. C. and Huwyler, J. (2014) “High-throughput viscosity measurement using capillary electrophoresis instrumentation and its application to protein formulation”, Journal of pharmaceutical and biomedical analysis. Elsevier, Vol. 99, pp. 51–58. doi: 10.1016/j.jpba.2014.07.005.   edoc
Kunze, A., Huwyler, J., Camenisch, G. and Poller, B. (2014) “Prediction of OATP1B1 and OATP1B3 Mediated Hepatic Uptake of Statins Based on Transporter Protein Expression and Activity Data”, Drug metabolism and disposition. Williams and Wilkins, Vol. 42, H. 9, pp. 1514–1521. doi: 10.1124/dmd.114.058412.   edoc
Kunze, A., Huwyler, J., Poller, B., Gutmann, H. and Camenisch, G. (2014) “In vitro-in vivo extrapolation method to predict human renal clearance of drugs”, Journal of pharmaceutical sciences. American Pharmaceutical Association, Vol. 103, H. 3, pp. 994–1001. doi: 10.1002/jps.23851.   edoc
Eberle, V. A., Schoelkopf, J., Gane, P. A., Alles, R., Huwyler, J. and Puchkov, M. (2014) “Floating gastroretentive drug delivery systems : comparison of experimental and simulated dissolution profiles and floatation behavior”, European journal of pharmaceutical sciences. Elsevier, Vol. 58, pp. 34–43. doi: 10.1016/j.ejps.2014.03.00.   edoc
Camblin, M., Detampel, P., Kettiger, H., Wu, D., Balasubramanian, V. and Huwyler, J. (2014) “Polymersomes containing quantum dots for cellular imaging”, International journal of nanomedicine. Dove Medical Press, Vol. 9, pp. 2287–2298. doi: 10.2147/IJN.S59189.   edoc
Preisig, D., Haid, D., Varum, F. J., Bravo, R., Huwyler, J. and Puchkov, M. (2014) “Drug loading into porous calcium carbonate microparticles by solvent evaporation”, European journal of pharmaceutics and biopharmaceutics. Elsevier, Vol. 87, H. 3, pp. 548–558.   edoc
Allmendinger, A., Fischer, S., Huwyler, J., Mahler, H. C., Schwarb, E., Zarraga, I. E. and Mueller, R. (2014) “Rheological characterization and injection forces of concentrated protein formulations : an alternative predictive model for non-Newtonian solutions”, European journal of pharmaceutics and biopharmaceutics. Elsevier, Vol. 87, H. 2, pp. 318–328. doi: 10.1016/j.ejpb.2014.01.009.   edoc
Dieu, L.-H. ., Wu, D. ., Palivan, C. G. ., Balasubramanian, V. . and Huwyler, J. (2014) “Polymersomes conjugated to 83-14 monoclonal antibodies : in vitro targeting of brain capillary endothelial cells”, European journal of pharmaceutics and biopharmaceutics. Elsevier, 88(2), pp. 316–324. doi: 10.1016/j.ejpb.2014.05.021.   edoc
Speich, B., Ame, S. M., Ali, S. M., Alles, R., Huwyler, J., Hattendorf, J., Utzinger, J., Albonico, M. and Keiser, J. (2014) “Oxantel pamoate-albendazole for Trichuris trichiura infection”, The New England journal of medicine. Massachusetts Medical Society, Vol. 370, H. 7, pp. 610–620. doi: 10.1056/NEJMoa1301956.   edoc
Detampel, P., Witzigmann, D., Krähenbühl, S. and Huwyler, J. (2014) “Hepatocyte targeting using pegylated asialofetuin-conjugated liposomes”, Journal of drug targeting. Taylor & Francis, Vol. 22, No. 3, pp. 232–241. doi: 10.3109/1061186X.2013.860982.   edoc
Alles, R., Puchkov, M., Jablonski, C., Speich, B., Keiser, J. and Huwyler, J. (2013) “Development of oxantel tablets for pediatric clinical studies : a technical note”, Journal of drug delivery science and technology. Ed. de Santé, Vol. 23, H. 6, pp. 623–625.   edoc
Meister, I., Duthaler, U., Huwyler, J., Rinaldi, L., Bosco, A., Cringoli, G. and Keiser, J. (2013) “Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with Fasciola hepatica in sheep”, Veterinary parasitology. Elsevier, Vol. 198, H. 1-2, pp. 102–110. doi: 10.1016/j.vetpar.2013.08.007.   edoc
Schoenbaechler, A., Olfa, G., Huwyler, J., Frenz, M. and Pieles, U. (2013) “Indocyanine green loaded biocompatible nanoparticles: Stabilization of indocyanine green (ICG) using biocompatible silica-poly(; e; -caprolactone) grafted nanocomposites”, Journal of photochemistry and photobiology. A, Chemistry. Elsevier Sequoia, Vol. 261, pp. 12–19.   edoc
Kettiger, H., Schipanski, A., Wick, P. and Huwyler, J. (2013) “Engineered nanomaterial uptake and tissue distribution : from cell to organism”, International journal of nanomedicine. Dove Medical Press, Vol. 8, pp. 3255–3269.   edoc
Seeland, S., Torok, M., Kettiger, H., Treiber, A., Hafner, M. and Huwyler, J. (2013) “A cell-based, multiparametric sensor approach characterises drug-induced cytotoxicity in human liver HepG2 cells”, Toxicology in vitro. Elsevier, Vol. 27, H. 3, pp. 1109–1120. doi: 10.1016/j.tiv.2013.02.001.   edoc
Fasler-Kan, E., Barteneva, N. S., Ketterer, S., Wunderlich, K., Reschner, A., Nurzhanova, A., Flammer, J., Huwyler, J. and Meyer, P. (2013) “Human cytokines activate JAK-STAT signaling pathway in porcine ocular tissue”, Xenotransplantation. Blackwell, Vol. 20, H. 6, pp. 469–480. doi: 10.1111/xen.12070.   edoc
Stirnimann, T., Di Maiuta, N., Gerard, D. E., Alles, R., Huwyler, J. and Puchkov, M. (2013) “Functionalized Calcium Carbonate as a Novel Pharmaceutical Excipient for the Preparation of Orally Dispersible Tablets”, Pharmaceutical research. Plenum Press, Vol. 30, H. 7, pp. 1915–1925. doi: 10.1007/s11095-013-1034-3.   edoc
Sano, Y., Kashiwamura, Y., Abe, M., Dieu, L. H., Huwyler, J., Shimizu, F., Haruki, H., Maeda, T., Saito, K., Tasaki, A. and Kanda, T. (2012) “A stable human brain microvascular endothelial cell line retaining its barrier-specific nature, independent of the passage number”, Clinical and experimental neuroimmunology. Wiley-Blackwell, Vol. 3, pp. 1–12.   edoc
Detampel, P., Beck, M., Krähenbühl, S. and Huwyler, J. (2012) “Drug interaction potential of resveratrol”, Drug metabolism reviews, Vol. 44, H. 3, pp. 253–265. doi: 10.3109/03602532.2012.700715.   edoc
Simmler, L. D., Buser, T. A., Donzelli, M., Schramm, Y., Dieu, L. H., Huwyler, J., Chaboz, S., Hoener, M. C. and Liechti, M. E. (2012) “Pharmacological characterization of designer cathinones in vitro”, British journal of pharmacology. Nature Publishing Group, Vol. 168, no. 2, pp. 458–470. doi: 10.1111/j.1476-5381.2012.02145.x.   edoc
Kirchhofer, C., Vargas, M., Huwyler, J. and Keiser, J. (2012) “Pharmacokinetics of the fasciocidal drug candidates MT04 and OZ78 in uninfected rats and in vitro pharmacodynamic studies”, International journal for parasitology: drugs and drug resistance. Elsevier, Vol. 2, pp. 121–125. doi: 10.1016/j.ijpddr.2012.03.003.   edoc
Duthaler, U., Huwyler, J., Rinaldi, L., Cringoli, G. and Keiser, J. (2012) “Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with Fasciola hepatica”, Veterinary parasitology. Elsevier, Vol. 186, H. 3-4, pp. 270–280. doi: 10.1016/j.vetpar.2011.11.076.   edoc
Hysek, C. M., Simmler, L. D., Nicola, V. G., Vischer, N., Donzelli, M., Krahenbuhl, S., Grouzmann, E., Huwyler, J., Hoener, M. C. and Liechti, M. E. (2012) “Duloxetine inhibits effects of MDMA (‘ecstasy’) in vitro and in humans in a randomized placebo-controlled laboratory study”, PLoS ONE. Public Library of Science, Vol. 7, H. 5 , e36476. doi: 10.1371/journal.pone.0036476.   edoc
Suenderhauf, C., Hammann, F. and Huwyler, J. (2012) “Computational Prediction of Blood-Brain Barrier Permeability Using Decision Tree Induction”, Molecules. MDPI, Vol. 17, H. 9, pp. 10429–10445. doi: 10.3390/molecules170910429.   edoc
Kunze, A., Huwyler, J., Camenisch, G. and Gutmann, H. (2012) “Interaction of the antiviral drug telaprevir with renal and hepatic drug transporters”, Biochemical pharmacology. Pergamon Press, Vol. 84, Issue 8, pp. 1096–1102.   edoc
Hysek, C. M., Simmler, L. D., Ineichen, M., Grouzmann, E., Hoener, M. C., Brenneisen, R., Huwyler, J. and Liechti, M. E. (2011) “The Norepinephrine Transporter Inhibitor Reboxetine Reduces Stimulant Effects of MDMA (‘Ecstasy’) in Humans”, Clinical pharmacology and therapeutics. Mosby, 90(2), pp. 246–255. doi: 10.1038/clpt.2011.78.   edoc
Duthaler, U., Keiser, J. and Huwyler, J. (2011) “Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether, and their major metabolites dihydroartemisinin and dihydroartemisininglucuronide in sheep plasma”, Journal of Mass Spectrometry. Wiley, 46(2), pp. 172–181. doi: 10.1002/jms.1883.   edoc
Schmutz, H.-R., Detampel, P., Bühler, T., Büttler, A., Gygax, B. and Huwyler, J. (2011) “In Vitro Assessment of the Formation of Ceftriaxone-Calcium Precipitates in Human Plasma”, Journal of pharmaceutical sciences. American Pharmaceutical Association, Vol. 100, H. 6, pp. 2300–2310.   edoc
Seeland, S., Treiber, A., Hafner, M. and Huwyler, J. (2011) “On-line identification of P-glycoprotein substrates by monitoring of extracellular acidification and respiration rates in living cells”, Biochimica et biophysica acta. Elsevier, Vol. 1808, H. 7, pp. 1827–1831.   edoc
Hammann, F., Suenderhauf, C. and Huwyler, J. (2011) “A Binary Ant Colony Optimization Classifier for Molecular Activities”, Journal of Chemical Information and Modeling. American Chemical Society, Vol. 51, pp. 2690–2696. doi: 10.1021/ci200186m.   edoc
Schroeder, K., Bremm, K. D., Alepee, N., Bessems, J. G., Blaauboer, B., Boehn, S. N., Burek, C., Coecke, S., Gombau, L., Hewitt, N. J., Heylings, J., Huwyler, J., Jaeger, M., Jagelavicius, M., Jarrett, N., Ketelslegers, H., Kocina, I., Koester, J., Kreysa, J., Note, R., Poth, A., Radtke, M., Rogiers, V., Scheel, J., Schulz, T., Steinkellner, H., Toeroek, M., Whelan, M., Winkler, P. and Diembeck, W. (2011) “Report from the EPAA workshop : in vitro ADME in safety testing used by EPAA industry sectors”, Toxicology in vitro. Elsevier, Vol. 25, H. 3, pp. 589–604. doi: 10.1016/j.tiv.2010.12.005.   edoc
Suenderhauf, C., Hammann, F., Maunz, A., Helma, C. and Huwyler, J. (2011) “Combinatorial QSAR Modeling of human Intestinal Absorption”, Molecular pharmaceutics. American Chemical Society, Vol. 8, H. 1, pp. 213–224. doi: 10.1021/mp100279d.   edoc
Huwyler, J. (2011) “Die neue pharmazeutische Technologie der Universität Basel”, Swiss Journal of the pharmaceutical industry, pp. 3–11.   
Fasler-Kan, E., Barteneva, N., Ketterer, S., Wunderlich, K., Huwyler, J., Gygax, D., Flammer, J. and Meyer, P. (2010) “Activation of the JAK?STAT intracellular pathway in human retinal pigment epithelialcell line ARPE-19”, International Journal of Interferon, Cytokine and Mediator Research. Dove Medical Press, Vol. 2, pp. 127–136.   edoc
Boehringer, M., Fischer, H., Hennig, M., Hunziker, D., Huwyler, J., Kuhn, B., Loeffler, B. M., Luebbers, T., Mattei, P., Narquizian, R., Sebokova, E., Sprecher, U. and Wessel, H. P. (2010) “Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors”, Bioorganic & medicinal chemistry letters. Pergamon, Vol. 20, H. 3, pp. 1106–1108.   edoc
Richter, H. G., Freichel, C., Huwyler, J., Nakagawa, T., Nettekoven, M., Plancher, J. M., Raab, S., Roche, O., Schuler, F., Taylor, S., Ullmer, C. and Wiegand, R. (2010) “Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold”, Bioorganic & medicinal chemistry letters. Pergamon, Vol. 20, H. 19, pp. 5713–5717.   edoc
Woltering, T. J., Wichmann, J., Goetschi, E., Knoflach, F., Ballard, T. M., Huwyler, J. and Gatti, S. (2010) “Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives : Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists”, Bioorganic & medicinal chemistry letters. Pergamon, Vol. 20, H. 23, pp. 6969–6974.   edoc
Kirchhofer, C., Keiser, J. and Huwyler, J. (2010) “Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate”, Journal of chromatography B. Elsevier, Vol. 878, H. 28, pp. 2770–2774.   edoc
Fasler-Kan, E., Suenderhauf, C., Barteneva, N., Poller, B., Gygax, D. and Huwyler, J. (2010) “Cytokine signaling in the human brain capillary endothelial cell line hCMEC/D3”, Brain research. Elsevier, Vol. 1354, pp. 15–22.   edoc
Keiser, J., Kirchhofer, C., Haschke, M., Huwyler, J., Dong, Y., Vennerstrom, J. L., Vanhoff, K., Kaminsky, R. and Malikides, N. (2010) “Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep”, Veterinary parasitology. Elsevier, Vol. 173, H. 3-4, pp. 228–235.   edoc
Mattei, P., Boehringer, M., Di Giorgio, P., Fischer, H., Hennig, M., Huwyler, J., Kocer, B., Kuhn, B., Loeffler, B. M., Macdonald, A., Narquizian, R., Rauber, E., Sebokova, E. and Sprecher, U. (2010) “Discovery of carmegliptin : a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes”, Bioorganic & medicinal chemistry letters. Pergamon, Vol. 20, H. 3, pp. 1109–1113.   edoc
Poller, B., Drewe, J., Krähenbühl, S., Huwyler, J. and Gutmann, H. (2010) “Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier”, Cellular and Molecular Neurobiology. Plenum Press, Vol. 30, No. 1, pp. 63–70.   edoc
Pierson, P. D., Freichel, C., Gatti-Mac Arthur, S., Hertel, C., Huwyler, J., Mohr, P., Nakagawa, T., Nettekoven, M., Plancher, J.-M., Raab, S., Richter, H., Roche, O., Rodríguez Sarmiento, R. M., Schmitt, M., Schuler, F., Takahashi, T., Taylor, S., Ullmer, C. and Wiegand, R. (2009) “Histamine-3 Receptor Inverse Agonists for the Treatment of Obesity: Validation of the Target and Identification of Novel Series”, Chimia. Schweizerische Chemische Gesellschaft, 63(5), pp. 275–278(4). doi: 10.2533/chimia.2009.275.   edoc
Vieira, E., Huwyler, J., Jolidon, S., Knoflach, F., Mutel, V. and Wichmann, J. (2009) “Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers”, Bioorganic and Medicinal Chemistry Letters. Elsevier, 19(6), pp. 1666–1669. doi: 10.1016/j.bmcl.2009.01.108.   edoc
Pierson, P. D., Fettes, A., Freichel, C., Gatti-McArthur, S., Hertel, C., Huwyler, J., Mohr, P., Nakagawa, T., Nettekoven, M., Plancher, J.-M., Raab, S., Richter, H., Roche, O., Rodríguez Sarmiento, R. M., Schmitt, M., Schuler, F., Takahashi, T., Taylor, S., Ullmer, C. and Wiegand, R. (2009) “5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity”, Journal of Medicinal Chemistry. American Chemical Society, 52(13), pp. 3855–3868. doi: 10.1021/jm900409x.   edoc
Du-Cuny, L., Huwyler, J., Wiese, M. and Kansy, M. (2008) “Computational aqueous solubility prediction for drug-like compounds in congeneric series”, European Journal of Medicinal Chemistry. Elsevier, 43(3), pp. 501–512. doi: 10.1016/j.ejmech.2007.04.009.   edoc
Bendels, S., Kansy, M., Wagner, B. and Huwyler, J. (2008) “In silico prediction of brain and CSF permeation of small molecules using PLS regression models”, European Journal of Medicinal Chemistry. Elsevier, 43(8), pp. 1581–1592. doi: 10.1016/j.ejmech.2007.11.011.   edoc
Tuffin, G., Huwyler, J., Waelti, E., Hammer, C. and Marti, H.-P. (2008) “Drug targeting using OX7-immunoliposomes: Correlation between Thy1.1 antigen expression and tissue distribution in the rat”, Journal of Drug Targeting. Taylor & Francis, 16(2), pp. 156–166. doi: 10.1080/10611860701848944.   edoc
Woltering, T. J., Wichmann, J., Goetschi, E., Adam, G., Kew, J. N. C., Knoflach, F., Ballard, T. M., Huwyler, J., Mutel, V. and Gatti, S. (2008) “Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists”, Bioorganic and Medicinal Chemistry Letters. Elsevier, 18(8), pp. 2725–2729. doi: 10.1016/j.bmcl.2008.02.076.   edoc
Huwyler, J., Drewe, J. and Krähenbuhl, S. (2008) “Tumor targeting using liposomal antineoplastic drugs”, International Journal of Nanomedicine. Dove Medical Press, 3(1), pp. 21–29.   edoc
Poller, B., Gutmann, H., Krähenbühl, S., Weksler, B., Romero, I., Couraud, P. O., Tuffin, G., Drewe, J. and Huwyler, J. (2008) “The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies”, Journal of Neurochemistry. Wiley-Blackwell, Vol. 107, H. 5, pp. 1358–1368.   edoc
Ceccarelli, S. M., Jaeschke, G., Buettelmann, B., Huwyler, J., Kolczewski, S., Peters, J.-U., Prinssen, E., Porter, R., Spooren, W. and Vieira, E. (2007) “Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam structure”, Bioorganic and Medicinal Chemistry Letters. Elsevier, 17(5), pp. 1302–1306. doi: 10.1016/j.bmcl.2006.12.006.   edoc
Jaeschke, G., Porter, R., Büttelmann, B., Ceccarelli, S. M., Guba, W., Kuhn, B., Kolczewski, S., Huwyler, J., Mutel, V., Peters, J.-U., Ballard, T., Prinssen, E., Vieira, E., Wichmann, J. and Spooren, W. (2007) “Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists”, Bioorganic and Medicinal Chemistry Letters. Elsevier, 17(5), pp. 1307–1311. doi: 10.1016/j.bmcl.2006.12.033.   edoc
Du-Cuny, L., Huwyler, J., Fischer, H. and Kansy, M. (2007) “A potentiometric titration method for the crystallization of drug-like organic molecules”, International Journal of Pharmaceutics. Elsevier, 342(1-2), pp. 161–167. doi: 10.1016/j.ijpharm.2007.05.030.   edoc
Büttelmann, B., Peters, J.-U., Ceccarelli, S., Kolczewski, S., Vieira, E., Prinssen, E. P., Spooren, W., Schuler, F., Huwyler, J., Porter, R. H. P. and Jaeschke, G. (2006) “Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists”, Bioorganic and Medicinal Chemistry Letters. Elsevier, 16(7), pp. 1892–1897. doi: 10.1016/j.bmcl.2005.12.088.   edoc
Huwyler, J., Wright, M. B., Gutmann, H. and Drewe, J. (2006) “Induction of Cytochrome P450 3A4 and P-Glycoprotein by the Isoxazolyl-Penicillin Antibiotic Flucloxacillin”, Current Drug Metabolism. Bentham Science Publishers, 7(2), pp. 119–126.   edoc
Tuffin, G., Waelti, E., Huwyler, J., Hammer, C. and Marti, H.-P. (2005) “Immunoliposome Targeting to Mesangial Cells: A Promising Strategy for Specific Drug Delivery to the Kidney”, Journal of the American Society of Nephrology. Williams and Wilkins, 16(11), pp. 3295–3305. doi: 10.1681/ASN.2005050485.   edoc
Schnyder, A., Krähenbühl, S., Drewe, J. and Huwyler, J. (2005) “Targeting of daunomycin using biotinylated immunoliposomes: Pharmacokinetics, tissue distribution and in vitro pharmacological effects”, Journal of Drug Targeting. Taylor & Francis, 13(5), pp. 325–335. doi: 10.1080/10611860500206674.   edoc