Publications

Brussee, J. M., Hiroshige, N., Neodo, A., Coulibaly, J. T., Pfister, M. and Keiser, J. (2021) “Population pharmacokinetics and exposure-response analysis of tribendimidine to improve treatment for children with hookworm infection”, Antimicrobial agents and chemotherapy, 65(2), pp. e01778–20. doi: 10.1128/AAC.01778-20.   
Bosch, F., Palmeirim, M. S., Ali, S. M., Ame, S. M., Hattendorf, J. and Keiser, J. (2021) “Diagnosis of soil-transmitted helminths using the Kato-Katz technique: what is the influence of stirring, storage time and storage temperature on stool sample egg counts?”, PLoS neglected tropical diseases, 15, p. e0009032. doi: 10.1371/journal.pntd.0009032.   
Brussee, J. M., Neodo, A., Schulz, J. D., Coulibaly, J. T., Pfister, M. and Keiser, J. (2021) “Pharmacometric analysis of tribendimidine mono- and combination therapies to achieve high cure rates in patients with hookworm infections”, Antimicrobial agents and chemotherapy, 65(2), pp. e00714–20. doi: 10.1128/AAC.00714-20.   
Keiser, J., Koch, V., Deckers, A., Cheung, H. T. A., Jung, N. and Bräse, S. (2020) “Naturally occurring cardenolides affecting Schistosoma mansoni”, ACS infectious diseases. ACS Publications, 6(7), pp. 1922–1927. doi: 10.1021/acsinfecdis.0c00175.   edoc
Levecke, B., Cools, P., Albonico, M., Ame, S., Angebault, C., Ayana, M., Behnke, J. M., Bethony, J. M., Cringoli, G., Dana, D., Guillard, B., Viet Hoa, N. T., Kang, G., Kattula, D., Keiser, J., Kotze, A. C., Matoso, L. F., Maurelli, M. P., McCarthy, J. S., Mekonnen, Z., Mirams, G., Montresor, A., Oliveira, R. C., Periago, M. V., Pinto, S. A., Rinaldi, L., Sayasone, S., Sumo, L., Tchuem-Tchuenté, L.-A., Cam Thach, D. T., Thomas, E., Zeynudin, A., Verweij, J. J., Vlaminck, J. and Vercruysse, J. (2020) “Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR”, PLoS Neglected Tropical Diseases. Public Library of Science, 14(7), p. e0008296. doi: 10.1371/journal.pntd.0008296.   edoc
Probst, A., Häberli, C., Siegel, D., Huang, J., Vigneron, S., Ta, A. P., Skinner, D. E., El-Sakkary, N., Momper, J. D., Gangoiti, J., Dong, Y., Vennerstrom, J. L., Charman, S. A., Caffrey, C. R. and Keiser, J. (2020) “Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone”, The journal of antimicrobial chemotherapy. Academic Press, p. dkaa247. doi: 10.1093/jac/dkaa247.   edoc
Olliaro, P. L., Coulibaly, J. T., Garba, A., Halleux, C., Keiser, J., King, C. H., Mutapi, F., N’Goran, E. K., Raso, G., Scherrer, A. U., Sousa-Figueiredo, J. C., Stete, K., Utzinger, J. and Vaillant, M. T. (2020) “Efficacy and safety of single 40 mg/kg oral praziquantel in the treatment of schistosomiasis in preschool-age versus school-age children: an individual participant data meta-analysis”, PLoS Neglected Tropical Diseases. Public Library of Science, 14(6), p. e0008277. doi: 10.1371/journal.pntd.0008277.   edoc
Buchter, V., Priotti, J., Leonardi, D., Lamas, M. C. and Keiser, J. (2020) “Activity of novel oral formulations of albendazole and mebendazole against Heligmosomoides polygyrus in vitro and in vivo”, Journal of pharmaceutical sciences. American Pharmaceutical Association, 109(5), pp. 1819–1826. doi: 10.1016/j.xphs.2020.02.002.   edoc
Lin, Y., Ong, Y. C., Keller, S., Karges, J., Bouchene, R., Manoury, E., Blacque, O., Müller, J., Anghel, N., Hemphill, A., Häberli, C., Taki, A. C., Gasser, R. B., Cariou, K., Keiser, J. and Gasser, G. (2020) “Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole”, Dalton Transactions. Royal Society of Chemistry, 49(20), pp. 6616–6626. doi: 10.1039/d0dt01107j.   edoc
Patel, C., Coulibaly, J. T., Schulz, J. D., N’Gbesso, Y., Hattendorf, J. and Keiser, J. (2020) “Efficacy and safety of ascending dosages of albendazole against Trichuris trichiura in preschool-aged children, school-aged children and adults: a multi-cohort randomized controlled trial”, EClinicalMedicine. Elsevier , 22, p. 100335. doi: 10.1016/j.eclinm.2020.100335.   edoc | Open Access
Buchter, V., Priotti, J., Leonardi, D., Lamas, M. C. and Keiser, J. (2020) “Preparation, physicochemical characterization and In vitro and In vivo activity against Heligmosomoides polygyrus of novel oral formulations of albendazole and mebendazole”, Journal of pharmaceutical sciences. American Pharmaceutical Association, 109(5), pp. 1819–1826. doi: 10.1016/j.xphs.2020.02.002.   edoc
Else, K. J., Keiser, J., Holland, C. V., Grencis, R. K., Sattelle, D. B., Fujiwara, R. T., Bueno, L. L., Asaolu, S. O., Sowemimo, O. A. and Cooper, P. J. (2020) “Whipworm and roundworm infections”, Nature Reviews. Disease Primers. Nature Publishing Group, 6(1), p. 44. doi: 10.1038/s41572-020-0171-3.   edoc
Wu, J., Wang, X., Chiu, F. C. K., Häberli, C., Shackleford, D. M., Ryan, E., Kamaraj, S., Bulbule, V. J., Wallick, A. I., Dong, Y., White, K. L., Davis, P. H., Charman, S. A., Keiser, J. and Vennerstrom, J. L. (2020) “Structure-activity relationship of antischistosomal ozonide carboxylic acids”, Journal of medicinal chemistry. American Chemical Society, 63(7), pp. 3723–3736. doi: 10.1021/acs.jmedchem.0c00069.   edoc
Moser, W., Keiser, J., Speich, B., Sayasone, S., Knopp, S. and Hattendorf, J. (2020) “One mean to rule them all? The arithmetic mean based egg reduction rate can be misleading when estimating anthelminthic drug efficacy in clinical trials”, PLoS Neglected Tropical Diseases. Public Library of Science, 14(4), p. e0008185. doi: 10.1371/journal.pntd.0008185.   edoc
Vlaminck, J., Cools, P., Albonico, M., Ame, S., Chanthapaseuth, T., Viengxay, V., Do Trung, D., Osei-Atweneboana, M. Y., Asuming-Brempong, E., Jahirul Karim, M., Al Kawsar, A., Keiser, J., Khieu, V., Faye, B., Turate, I., Mbonigaba, J. B., Ruijeni, N., Shema, E., Luciañez, A., Santiago Nicholls, R., Jamsheed, M., Mikhailova, A., Montresor, A., Mupfasoni, D., Yajima, A., Ngina Mwinzi, P., Gilleard, J., Prichard, R. K., Verweij, J. J., Vercruysse, J. and Levecke, B. (2020) “Piloting a surveillance system to monitor the global patterns of drug efficacy and the emergence of anthelmintic resistance in soil-transmitted helminth control programs: a Starworms study protocol”, Gates open research, 4, p. 28. doi: 10.12688/gatesopenres.13115.1.   edoc | Open Access
Zanolla, D., Hasa, D., Arhangelskis, M., Schneider-Rauber, G., Chierotti, M. R., Keiser, J., Voinovich, D., Jones, W. and Perissutti, B. (2020) “Mechanochemical formation of racemic praziquantel hemihydrate with improved biopharmaceutical properties”, Biopharmaceutics & drug disposition, 12(3), p. 289. doi: 10.3390/pharmaceutics12030289.   edoc | Open Access
Keller, L., Palmeirim, M. S., Ame, S. M., Ali, S. M., Puchkov, M., Huwyler, J., Hattendorf, J. and Keiser, J. (2020) “Efficacy and safety of ascending dosages of moxidectin and moxidectin-albendazole against Trichuris trichiura in adolescents: a randomized controlled trial”, Clinical Infectious Diseases. Oxford University Press, 70(6), pp. 1193–1201. doi: 10.1093/cid/ciz326.   edoc
De Rycker, M., Horn, D., Aldridge, B., Amewu, R. K., Barry, C. E., Buckner, F. S., Cook, S., Ferguson, M. A. J., Gobeau, N., Herrmann, J., Herrling, P., Hope, W., Keiser, J., Lafuente-Monasterio, M. J., Leeson, P. D., Leroy, D., Manjunatha, U. H., McCarthy, J., Miles, T. J., Mizrahi, V., Moshynets, O., Niles, J., Overington, J. P., Pottage, J., Rao, S. P. S., Read, K. D., Ribeiro, I., Silver, L. L., Southern, J., Spangenberg, T., Sundar, S., Taylor, C., Van Voorhis, W., White, N. J., Wyllie, S., Wyatt, P. G. and Gilbert, I. H. (2020) “Setting our sights on infectious diseases”, ACS infectious diseases. ACS Publications, 6(1), pp. 3–13. doi: 10.1021/acsinfecdis.9b00371.   edoc | Open Access
Palmeirim, M. S., Ross, A., Obrist, B., Mohammed, U. A., Ame, S. M., Ali, S. M. and Keiser, J. (2020) “Informed consent procedure in a double blind randomized anthelminthic trial on Pemba Island, Tanzania: do pamphlet and information session increase caregivers knowledge?”, BMC medical ethics. BioMed Central, 21, p. 1. doi: 10.1186/s12910-019-0441-3.   edoc | Open Access
Wagner-Hattler , L., Quebatte, G., Keiser, J., Schoelkopf, J., Schleputz, C. M., Huwyler, J. and Puchkov, M. (2020) “Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering”, International journal of pharmaceutics. Elsevier, 573, p. 118827. doi: 10.1016/j.ijpharm.2019.118827.   edoc
Buchter, V., Ong, Y. C., Mouvet, F., Ladaycia, A., Lepeltier, E., Rothlisberger, U., Keiser, J. and Gasser, G. (2020) “Multidisciplinary preclinical investigations on three oxamniquine analogues as novel drug candidates for schistosomiasis”, Chemistry (Weinheim an der Bergstrasse, Germany), 26(66), pp. 15232–15241. doi: 10.1002/chem.202002856.   
Vlaminck, J., Cools, P., Albonico, M., Ame, S., Ayana, M., Dana, D., Keiser, J., Matoso, L. F., Montresor, A., Mekonnen, Z., Corrêa-Oliveira, R., Pinto, S. A., Sayasone, S., Vercruysse, J. and Levecke, B. (2020) “An in-depth report of quality control on Kato-Katz and data entry in four clinical trials evaluating the efficacy of albendazole against soil-transmitted helminth infections”, PLoS neglected tropical diseases, 14(9), p. e0008625. doi: 10.1371/journal.pntd.0008625.   
Ravaynia, P. S., Lombardo, F. C., Biendl, S., Dupuch, M. A., Keiser, J., Hierlemann, A. and Modena, M. M. (2020) “Parallelized impedance-based platform for continuous dose-response characterization of antischistosomal drugs”, Advanced biosystems, 4(7), p. e1900304. doi: 10.1002/adbi.201900304.   
Barda, B., Schindler, C., Wampfler, R., Ame, S., Ali, S. M. and Keiser, J. (2020) “Comparison of real-time PCR and the Kato-Katz method for the diagnosis of soil-transmitted helminthiasis and assessment of cure in a randomized controlled trial”, BMC microbiology, 20, p. 298. doi: 10.1186/s12866-020-01963-9.   
Kyne, G. M., Curtis, M. P., Keiser, J. and Woods, D. J. (2019) “Soil-transmitted helminthiasis - challenges with discovery of novel anthelmintics”, in Swinney, D. C. and Pollastri, M. P. (eds.) Neglected tropical diseases: drug discovery and development. Weinheim: Wiley, pp. 227–251. doi: 10.1002/9783527808656.ch9.   edoc
Zanolla, D., Perissutti, B., Vioglio, P. C., Chierotti, M. R., Gigli, L., Demitri, N., Passerini, N., Albertini, B., Franceschinis, E., Keiser, J. and Voinovich, D. (2019) “Exploring mechanochemical parameters using a DoE approach: Crystal structure solution from synchrotron XRPD and characterization of a new praziquantel polymorph”, European Journal of Pharmaceutical Sciences. Elsevier, 140, p. 105084. doi: 10.1016/j.ejps.2019.105084.   edoc
Maccesi, M., Aguiar, P. H. N., Pasche, V., Padilla, M., Suzuki, B. M., Montefusco, S., Abagyan, R., Keiser, J., Mourão, M. M. and Caffrey, C. R. (2019) “Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery”, Parasites and Vectors. BioMed Central, 12(1), p. 493. doi: 10.1186/s13071-019-3747-6.   edoc | Open Access
Hürlimann, E. and Keiser, J. (2019) “A single dose of ivermectin is sufficient for strongyloidiasis”, The Lancet infectious diseases. Elsevier, 19(11), pp. 1150–1151. doi: 10.1016/S1473-3099(19)30519-5.   edoc
Wimmersberger, D., Schulz, J. D. and Keiser, J. (2019) “Reply to Nalin”, Clinical infectious diseases. Oxford University Press, 69(2), pp. 376–377. doi: 10.1093/cid/ciy1015.   edoc
Brecht, K., Kirchhofer, C., Bouitbir, J., Trapani, F., Keiser, J. and Krähenbühl, S. (2019) “Exogenous iron increases fasciocidal activity and hepatocellular toxicity of the synthetic endoperoxides OZ78 and MT04”, International Journal of Molecular Sciences. Molecular Diversity Preservation International, 20(19), p. 4880. doi: 10.3390/ijms20194880.   edoc | Open Access
Wimmersberger, D., Schulz, J. D. and Keiser, J. (2019) “Antihelminthic efficacy against trichuriasis reply”, Clinical infectious diseases. Oxford University Press, 69(2), pp. 376–377. doi: 10.1093/cid/ciy1015.   edoc
Lombardo, F. C., Perissutti, B. and Keiser, J. (2019) “Activity and pharmacokinetics of a praziquantel crystalline polymorph in the Schistosoma mansoni mouse model”, European Journal of Pharmaceutics and Biopharmaceutics. Elsevier, 142, pp. 240–246. doi: 10.1016/j.ejpb.2019.06.029.   edoc
Coulibaly, J. T., Hiroshige, N., N’Gbesso, Y. K., Hattendorf, J. and Keiser, J. (2019) “Efficacy and safety of ascending dosages of tribendimidine against hookworm infections in children : a randomized controlled trial”, Clinical Infectious Diseases. Oxford University Press, 69(5), pp. 845–852. doi: 10.1093/cid/ciy999.   edoc
Brussee, J. M., Schulz, J. D., Coulibaly, J. T., Keiser, J. and Pfister, M. (2019) “Ivermectin dosing strategy to achieve equivalent exposure coverage in children and adults”, Clinical pharmacology and therapeutics. Mosby, 106(3), pp. 661–667. doi: 10.1002/cpt.1456.   edoc
Cools, P., Vlaminck, J., Albonico, M., Ame, S., Ayana, M., José Antonio, B. P., Cringoli, G., Dana, D., Keiser, J., Maurelli, M. P., Maya, C., Matoso, L. F., Montresor, A., Mekonnen, Z., Mirams, G., Corrêa-Oliveira, R., Pinto, S. A., Rinaldi, L., Sayasone, S., Thomas, E., Verweij, J. J., Vercruysse, J. and Levecke, B. (2019) “Diagnostic performance of a single and duplicate Kato-Katz, Mini-FLOTAC, FECPAKG2 and qPCR for the detection and quantification of soil-transmitted helminths in three endemic countries”, PLoS Neglected Tropical Diseases. Public Library of Science, 13(8), p. e0007446. doi: 10.1371/journal.pntd.0007446.   edoc | Open Access
Vlaminck, J., Cools, P., Albonico, M., Ame, S., Ayana, M., Cringoli, G., Dana, D., Keiser, J., Maurelli, M. P., Matoso, L. F., Montresor, A., Mekonnen, Z., Mirams, G., Corrêa-Oliveira, R., Pinto, S. A., Rinaldi, L., Sayasone, S., Thomas, E., Vercruysse, J., Verweij, J. J. and Levecke, B. (2019) “Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods”, PLoS Neglected Tropical Diseases. Public Library of Science, 13(8), p. e0007471. doi: 10.1371/journal.pntd.0007471.   edoc | Open Access
Bogoch, I. I., Speich, B., Lo, N. C., Moser, W., Croll, D., Ali, S. M., Ame, S. M., Utzinger, J., Andrews, J. R. and Keiser, J. (2019) “Clinical evaluation for morbidity associated with soil-transmitted helminth infection in school-age children on Pemba Island, Tanzania”, PLoS Neglected Tropical Diseases. Public Library of Science, 13(7), p. e0007581. doi: 10.1371/journal.pntd.0007581.   edoc | Open Access
Keiser, J. and Utzinger, J. (2019) “Community-wide soil-transmitted helminth treatment is equity-effective”, Lancet. The Lancet, 393(10185), pp. 2011–2012. doi: 10.1016/S0140-6736(18)32981-7.   edoc | Open Access
Schulz, J. D., Coulibaly, J. T., Schindler, C., Wimmersberger, D. and Keiser, J. (2019) “Pharmacokinetics of ascending doses of ivermectin in Trichuris trichiura-infected children aged 2-12 years”, The journal of antimicrobial chemotherapy. Academic Press, 74(6), pp. 1642–1647. doi: 10.1093/jac/dkz083.   edoc | Open Access
Panic, G., Barda, B., Kovač, J., Coulibaly, J. T. and Keiser, J. (2019) “Evaluation of the Clinitek®, a point-of-care urinalysis system for the measurement of clinically significant urinary metabolites and detection of haematuria in Schistosoma haematobium infected children in southern Côte d’Ivoire”, Parasites and vectors. BioMedCentral, 12, p. 298. doi: 10.1186/s13071-019-3555-z.   edoc | Open Access
Karpstein, T., Pasche, V., Häberli, C., Scandale, I., Neodo, A. and Keiser, J. (2019) “Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections”, Parasites and Vectors. BioMed Central, 12, p. 226. doi: 10.1186/s13071-019-3476-x.   edoc | Open Access
Meister, I., Assawasuwannakit, P., Vanobberghen, F., Penny, M. A., Odermatt, P., Sayasone, S., Huwyler, J., Tarning, J. and Keiser, J. (2019) “Pooled population pharmacokinetic analysis of tribendimidine for the treatment of Opisthorchis viverrini infections”, Antimicrobial Agents and Chemotherapy. American Society for Microbiology, 63(4), pp. e01391–18. doi: 10.1128/AAC.01391-18.   edoc | Open Access
Schulz, J. D., Neodo, A., Coulibaly, J. T. and Keiser, J. (2019) “Pharmacokinetics of albendazole, albendazole sulfoxide and albendazole sulfone determined from plasma, blood, dried blood spots and Mitra® samples of hookworm-infected adolescents”, Antimicrobial agents and chemotherapy. American Society for Microbiology, 63(4), pp. e02489–18. doi: 10.1128/AAC.02489-18.   edoc
Le, T. G., Kundu, A., Ghoshal, A., Nguyen, N. H., Preston, S., Jiao, Y., Ruan, B., Xue, L., Huang, F., Keiser, J., Hofmann, A., Chang, B. C. H., Garcia-Bustos, J., Wells, T. N. C., Palmer, M. J., Jabbar, A., Gasser, R. B. and Baell, J. B. (2019) “Novel 1-methyl-1 H-pyrazole-5-carboxamide derivatives with potent anthelmintic activity”, Journal of medicinal chemistry. American Chemical Society, 62(7), pp. 3367–3380. doi: 10.1021/acs.jmedchem.8b01790.   edoc
Patel, C., Hürlimann, E., Keller, L., Hattendorf, J., Sayasone, S., Ali, S. M., Ame, S. M., Coulibaly, J. T. and Keiser, J. (2019) “Efficacy and safety of ivermectin and albendazole co-administration in school-aged children and adults infected with Trichuris trichiura : study protocol for a multi-country randomized controlled double-blind trial”, BMC infectious diseases. BioMed Central, 19, p. 262. doi: 10.1186/s12879-019-3882-x.   edoc | Open Access
Albertini, B., Perissutti, B., Bertoni, S., Zanolla, D., Franceschinis, E., Voinovich, D., Lombardo, F., Keiser, J. and Passerini, N. (2019) “Combining mechanochemistry and spray congealing for new praziquantel pediatric formulations in schistosomiasis treatment”, International journal of molecular sciences. Molecular Diversity Preservation International, 20(5), p. 1233. doi: 10.3390/ijms20051233.   edoc | Open Access
Moser, W., Schindler, C. and Keiser, J. (2019) “Drug combinations against soil-transmitted helminth infections”, Advances in parasitology. Elsevier, 103, pp. 91–115. doi: 10.1016/bs.apar.2018.08.002.   edoc
Mayoka, G., Keiser, J., Häberli, C. and Chibale, K. (2019) “Structure-activity relationship and in vitro absorption, distribution, metabolism, excretion, and toxicity (ADMET) studies of N-aryl 3-trifluoromethyl pyrido[1,2-a]benzimidazoles that are efficacious in a mouse model of Schistosomiasis”, ACS infectious diseases. ACS Publications, 5(3), pp. 418–429. doi: 10.1021/acsinfecdis.8b00313.   edoc
Le, T., Kundu, A., Ghoshal, A., Nguyen, N., Preston, S., Jiao, Y., Ruan, B., Xue, L., Huang, F., Keiser, J., Hofmann, A., Chang, B., Garcia-Bustos, J., Wells, T. N. C., Palmer, M. J., Jabbar, A., Gasser, R. B. and Baell, J. B. (2019) “Structure-activity relationship studies of tolfenpyrad reveal sub-nanomolar inhibitors of Haemonchus contortus development”, Journal of medicinal chemistry. American Chemical Society, 62(2), pp. 1036–1053. doi: 10.1021/acs.jmedchem.8b01789.   edoc
Lombardo, F. C., Pasche, V., Panic, G., Endriss, Y. and Keiser, J. (2019) “Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni”, Nature Protocols. Nature Publishing Group, 14(2), pp. 461–481. doi: 10.1038/s41596-018-0101-y.   edoc
Neodo, A., Schulz, J. D., Huwyler, J. and Keiser, J. (2019) “In vitro and In vivo drug-drug interaction study of the effects of ivermectin and oxantel pamoate on tribendimidine”, Antimicrobial agents and chemotherapy. American Society for Microbiology, 63(1), pp. e00762–18. doi: 10.1128/AAC.00762-18.   edoc
Coulibaly, J. T., Andrews, J. R., Lo, N. C., N’Goran, E. K., Utzinger, J., Keiser, J. and Bogoch, I. I. (2018) “Schistosoma haematobium egg excretion does not increase after exercise : implications for diagnostic testing”, American journal of tropical medicine and hygiene. Williams and Wilkins, 98(3), pp. 772–775. doi: 10.4269/ajtmh.17-0728.   edoc
Moser, W., Barenbold, O., Mirams, G. J., Cools, P., Vlaminck, J., Ali, S. M., Ame, S. M., Hattendorf, J., Vounatsou, P., Levecke, B. and Keiser, J. (2018) “Diagnostic comparison between FECPAKG2 and the Kato-Katz method for analyzing soil-transmitted helminth eggs in stool”, PLoS neglected tropical diseases. Public Library of Science, 12(6), p. e0006562. doi: 10.1371/journal.pntd.0006562.   edoc | Open Access
Pasche, V., Laleu, B. and Keiser, J. (2018) “Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni”, Parasites and Vectors. BioMed Central, 11, p. 298. doi: 10.1186/s13071-018-2855-z.   edoc | Open Access
Le, T. G., Kundu, A., Ghoshal, A., Nguyen, N. H., Preston, S., Jiao, Y., Ruan, B., Xue, L., Huang, F., Keiser, J., Hofmann, A., Chang, B. C. H., Garcia-Bustos, J., Jabbar, A., Wells, T. N. C., Palmer, M. J., Gasser, R. B. and Baell, J. B. (2018) “Optimization of novel 1-methyl-1 h-pyrazole-5-carboxamides leads to high potency larval development inhibitors of the barber’s pole worm”, Journal of medicinal chemistry. American Chemical Society, 61(23), pp. 10875–10894. doi: 10.1021/acs.jmedchem.8b01544.   edoc
Wu, J., Wang, C., Leas, D., Vargas, M., White, K. L., Shackleford, D. M., Chen, G., Sanford, A. G., Hemsley, R. M., Davis, P. H., Dong, Y., Charman, S. A., Keiser, J. and Vennerstrom, J. L. (2018) “Progress in antischistosomal N,N’-diaryl urea SAR”, Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines. Elsevier, 28(3), pp. 244–248. doi: 10.1016/j.bmcl.2017.12.064.   edoc
Palmeirim, M. S., Ame, S. M., Ali, S. M., Hattendorf, J. and Keiser, J. (2018) “Efficacy and safety of a single dose versus a multiple dose regimen of mebendazole against hookworm infections in children : a randomised, double-blind trial”, EClinicalMedicine. Elsevier , 1, pp. 7–13. doi: 10.1016/j.eclinm.2018.06.004.   edoc | Open Access
Chawla, K., Modena, M. M., Ravaynia, P. S., Lombardo, F. C., Leonhardt, M., Panic, G., Bürgel, S. C., Keiser, J. and Hierlemann, A. (2018) “Impedance-based microfluidic assay for automated antischistosomal drug screening”, ACS Sensors. American Chemical Society, 3(12), pp. 2613–2620. doi: 10.1021/acssensors.8b01027.   edoc
Pasche, V., Laleu, B. and Keiser, J. (2018) “Early antischistosomal leads identified from in vitro and in vivo screening of the medicines for malaria venture pathogen box”, ACS infectious diseases. ACS Publications, 5(1), pp. 102–110. doi: 10.1021/acsinfecdis.8b00220.   edoc
Bonate, P. L., Wang, T., Passier, P., Bagchus, W., Burt, H., Lüpfert, C., Abla, N., Kovac, J. and Keiser, J. (2018) “Extrapolation of praziquantel pharmacokinetics to a pediatric population : a cautionary tale”, Journal of pharmacokinetics and pharmacodynamics. Springer Science + Business Media B.V, 45(5), pp. 747–762. doi: 10.1007/s10928-018-9601-1.   edoc
Wu, J., Wang, C., Häberli, C., White, K. L., Shackleford, D. M., Chen, G., Dong, Y., Charman, S. A., Keiser, J. and Vennerstrom, J. L. (2018) “SAR of a new antischistosomal urea carboxylic acid”, Bioorganic & medicinal chemistry letters. Elsevier, 28(23-24), pp. 3648–3651. doi: 10.1016/j.bmcl.2018.10.039.   edoc
D’Orchymont, F. H., J. Panic, G. J., M. Gemperle, L. K. and J. Gasser, G. (2018) “Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidate”, MedChemComm . Royal Society of Chemistry, 9(44), pp. 1905–1909. doi: 10.1039/C8MD00396C.   edoc
Buchter, V., Hess, J., Gasser, G. and Keiser, J. (2018) “Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy”, Parasites and Vectors. BioMed Central, 11, p. 580. doi: 10.1186/s13071-018-3132-x.   edoc | Open Access
Vlaminck, J., Cools, P., Albonico, M., Ame, S., Ayana, M., Bethony, J., Cringoli, G., Dana, D., Keiser, J., Maurelli, M. P., Montresor, A., Mekonnen, Z., Mirams, G., Corrêa-Oliveira, R., Prichard, R., Rashwan, N., Rinaldi, L., Sayasone, S., Thomas, E., Verweij, J. J., Vercruysse, J. and Levecke, B. (2018) “Comprehensive evaluation of stool-based diagnostic methods and benzimidazole resistance markers to assess drug efficacy and detect the emergence of anthelmintic resistance : a Starworms study protocol”, PLoS Neglected Tropical Diseases. Public Library of Science, 12(11), p. e0006912. doi: 10.1371/journal.pntd.0006912.   edoc | Open Access
Liu, Z., Xia, B., Saric, J., Utzinger, J., Holmes, E., Keiser, J. and Li, J. V. (2018) “Effects of vancomycin and ciprofloxacin on the NMRI mouse metabolism”, Journal of Proteome Research. American Chemical Society, 17(10), pp. 3565–3573. doi: 10.1021/acs.jproteome.8b00583.   edoc
Ayana, M., Vlaminck, J., Cools, P., Ame, S., Albonico, M., Dana, D., Keiser, J., Manly, H., Matoso, L. F., Mekonnen, Z., Montresor, A., Correa-Oliveira, R., Rinaldi, L., Sayasone, S., Tesfaye, L., Vercruysse, J., Mirams, G. and Levecke, B. (2018) “Modification and optimization of the FECPAKG2 protocol for the detection and quantification of soil-transmitted helminth eggs in human stool”, PLoS Neglected Tropical Diseases. Public Library of Science, 12(10), p. e0006655. doi: 10.1371/journal.pntd.0006655.   edoc | Open Access
Wimmersberger, D., Coulibaly, J. T., Schulz, J. D., Puchkow, M., Huwyler, J., N’Gbesso, Y., Hattendorf, J. and Keiser, J. (2018) “Efficacy and safety of ivermectin against Trichuris trichiura in preschool- and school-aged children : a randomized controlled dose-finding trial”, Clinical Infectious Diseases. Oxford University Press, 67(8), pp. 1247–1255. doi: 10.1093/cid/ciy246.   edoc
Coulibaly, J. T., Ouattara, M., Barda, B., Utzinger, J., N’Goran, E. K. and Keiser, J. (2018) “A rapid appraisal of factors influencing praziquantel treatment compliance in two communities endemic for schistosomiasis in Côte d’Ivoire”, Tropical medicine and infectious disease. Multidisciplinary Digital Publishing Institute, 3(2), p. 69. doi: 10.3390/tropicalmed3020069.   edoc | Open Access
Hiroshige, N., Coulibaly, J., Huwyler, J., Bonate, P. L. and Keiser, J. (2018) “Pharmacokinetics of a Pediatric Tribendimidine Dose-Finding Study To Treat Hookworm Infection in African Children”, Antimicrobial agents and chemotherapy. American Society for Microbiology, 62(9), p. e00959. doi: 10.1128/AAC.00959-18.   edoc | Open Access
Becker, S. L., Liwanag, H. J., Snyder, J. S., Akogun, O., Belizario, V., Freeman, M. C., Gyorkos, T. W., Imtiaz, R., Keiser, J., Krolewiecki, A., Levecke, B., Mwandawiro, C., Pullan, R. L., Addiss, D. G. and Utzinger, J. (2018) “Toward the 2020 goal of soil-transmitted helminthiasis control and elimination”, PLoS Neglected Tropical Diseases. Public Library of Science, 12(8), p. e0006606. doi: 10.1371/journal.pntd.0006606.   edoc | Open Access
Panic, G. and Keiser, J. (2018) “Acting beyond 2020 : better characterization of praziquantel and promising antischistosomal leads”, Current Opinion in Pharmacology. Elsevier, pp. 27–33. doi: 10.1016/j.coph.2018.06.004.   edoc
Kovač, J., Meister, I., Neodo, A., Panic, G., Coulibaly, J. T., Falcoz, C. and Keiser, J. (2018) “Pharmacokinetics of praziquantel in Schistosoma mansoni and Schistosoma haematobium infected school- and preschool- aged children”, Antimicrobial agents and chemotherapy. American Society for Microbiology, 62(8), pp. e02253–17. doi: 10.1128/AAC.02253-17.   edoc
Kovač, J., Panic, G., Neodo, A., Meister, I., Coulibaly, J. T., Schulz, J. D. and Keiser, J. (2018) “Evaluation of a novel micro-sampling device, Mitratm, in comparison to dried blood spots, for analysis of praziquantel in Schistosoma haematobium-infected children in rural Côte d’Ivoire”, Journal of Pharmaceutical and Biomedical Analysis. Elsevier, 151, pp. 339–346. doi: 10.1016/j.jpba.2018.01.030.   edoc
Schneeberger, P. H. H., Coulibaly, J. T., Gueuning, M., Moser, W., Coburn, B., Frey, J. E. and Keiser, J. (2018) “Off-target effects of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel-pamoate, and albendazole plus oxantel-pamoate on the human gut microbiota”, International journal for parasitology. Drugs and drug resistance. Elsevier, 8(3), pp. 372–378. doi: 10.1016/j.ijpddr.2018.07.001.   edoc | Open Access
Schulz, J. D., Neodo, A., Coulibaly, J. T. and Keiser, J. (2018) “Development and validation of a LC-MS/MS method for ivermectin quantification in dried blood spots : application to a pharmacokinetic study in Trichuris trichiura-infected adults”, Analytical Methods. Royal Society of Chemistry, 10, pp. 2901–2909. doi: 10.1039/c8ay00828k.   edoc | Open Access
Schulz, J. D., Moser, W., Hürlimann, E. and Keiser, J. (2018) “Preventive chemotherapy in the fight against soil-transmitted Helminthiasis : achievements and limitations”, Trends in parasitology. Elsevier, 34(7), pp. 590–602. doi: 10.1016/j.pt.2018.04.008.   edoc
Moser, W., Sayasone, S., Xayavong, S., Bounheuang, B., Puchkov, M., Huwyler, J., Hattendorf, J. and Keiser, J. (2018) “Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate against hookworm infections in school-aged children in Laos : a randomised, single-blind trial”, The Lancet infectious diseases. Elsevier, 18(7), pp. 729–737. doi: 10.1016/S1473-3099(18)30220-2.   edoc
Barda, B., Ame, S. M., Ali, S. M., Albonico, M., Puchkov, M., Huwyler, J., Hattendorf, J. and Keiser, J. (2018) “Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections : a randomised, non-inferiority, single-blind trial”, The Lancet infectious diseases. Elsevier, 18(8), pp. 864–873. doi: 10.1016/S1473-3099(18)30233-0.   edoc
Panic, G., Coulibaly, J. T., Harvey, N., Keiser, J. and Swann, J. (2018) “Characterizing the biochemical response to Schistosoma mansoni infection and treatment with praziquantel in preschool and school aged children”, Journal of Proteome Research. American Chemical Society, 17(6), pp. 2028–2033. doi: 10.1021/acs.jproteome.7b00910.   edoc
Zanolla, D., Perissutti, B., Passerini, N., Chierotti, M. R., Hasa, D., Voinovich, D., Gigli, L., Demitri, N., Geremia, S., Keiser, J., Cerreia Vioglio, P. and Albertini, B. (2018) “A new soluble and bioactive polymorph of praziquantel”, European Journal of Pharmaceutics and Biopharmaceutics. Elsevier, 127, pp. 19–28. doi: 10.1016/j.ejpb.2018.01.018.   edoc
Coulibaly, J. T., Panic, G., Yapi, R. B., Kovač, J., Barda, B., N’Gbesso, Y. K., Hattendorf, J. and Keiser, J. (2018) “Efficacy and safety of ascending doses of praziquantel against Schistosoma haematobium infection in preschool-aged and school-aged children : a single-blind randomised controlled trial”, BMC Medicine. BioMed Central, 16, p. 81. doi: 10.1186/s12916-018-1066-y.   edoc | Open Access
Barda, B., Wampfler, R., Sayasone, S., Phongluxa, K., Xayavong, S., Keoduangsy, K., Schindler, C. and Keiser, J. (2018) “Evaluation of two DNA extraction methods for detection of Strongyloides stercoralis infection”, Journal of clinical microbiology, 56(4), pp. e01941–17. doi: 10.1128/JCM.01941-17.   edoc
Speich, B., von Niederhäusern, B., Blum, C. A., Keiser, J., Schur, N., Fürst, T., Kasenda, B., Christ-Crain, M., Hemkens, L. G., Pauli-Magnus, C., Schwenkglenks, M., Briel, M. and Making Randomized Trials Affordable Group (2018) “Retrospective assessment of resource use and costs in two investigator-initiated randomized trials exemplified a comprehensive cost item list”, Journal of clinical epidemiology. Pergamon Press, 96, pp. 73–83. doi: 10.1016/j.jclinepi.2017.12.022.   edoc
Sayasone, S., Keiser, J., Meister, I., Vonghachack, Y., Xayavong, S., Senggnam, K., Phongluxa, K., Hattendorf, J. and Odermatt, P. (2018) “Efficacy and safety of tribendimidine versus praziquantel against Opisthorchis viverrini in Laos : an open-label, randomised, non-inferiority, phase 2 trial”, The Lancet infectious diseases. Elsevier, 18(2), pp. 155–161. doi: 10.1016/S1473-3099(17)30624-2.   edoc
Levecke, B., Easton, A. V., Cools, P., Albonico, M., Ame, S., Gilleard, J. S., Keiser, J., Montresor, A., Prichard, R., Vlaminck, J. and Vercruysse, J. (2018) “The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans”, International Journal for Parasitology: Drugs and Drug Resistance. Elsevier, 8(1), pp. 67–69. doi: 10.1016/j.ijpddr.2017.12.004.   edoc | Open Access
Schneeberger, P. H. H., Coulibaly, J. T., Panic, G., Daubenberger, C., Gueuning, M., Frey, J. E. and Keiser, J. (2018) “Investigations on the interplays between Schistosoma mansoni, praziquantel and the gut microbiome”, Parasites and Vectors. BioMed Central, 11, p. 168. doi: 10.1186/s13071-018-2739-2.   edoc | Open Access
Perissutti, B., Passerini, N., Trastullo, R., Keiser, J., Zanolla, D., Zingone, G., Voinovich, D. and Albertini, B. (2017) “An explorative analysis of process and formulation variables affecting comilling in a vibrational mill: the case of praziquantel”, International journal of pharmaceutics. Elsevier, 533(2), pp. 402–412. doi: 10.1016/j.ijpharm.2017.05.053.   edoc
Moser, W., Schindler, C. and Keiser, J. (2017) “Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis”, BMJ. BMJ Publishing Group, 358, p. j4307. doi: 10.1136/bmj.j4307.   edoc | Open Access
Hess, J., Panic, G., Patra, M., Mastrobuoni, L., Spingler, B., Roy, S., Keiser, J. and Gasser, G. (2017) “Ferrocenyl, ruthenocenyl, and benzyl oxamniquine derivatives with cross-species activity against Schistosoma mansoni and Schistosoma haematobium”, ACS infectious diseases. ACS Publications, 3(9), pp. 645–652. doi: 10.1021/acsinfecdis.7b00054.   edoc
Panic, G., Ruf, M.-T. and Keiser, J. (2017) “Immunohistochemical investigations of treatment with Ro 13-3978, praziquantel, oxamniquine, and mefloquine in Schistosoma mansoni-infected mice”, Antimicrobial agents and chemotherapy. American Society for Microbiology, 61(12), pp. e01142–17. doi: 10.1128/AAC.01142-17.   edoc
Barda, B., Sayasone, S., Phongluxa, K., Xayavong, S., Keoduangsy, K., Odermatt, P., Puchkov, M., Huwyler, J., Hattendorf, J. and Keiser, J. (2017) “Efficacy of moxidectin versus ivermectin against Strongyloides stercoralis infections: a randomized controlled non-inferiority trial”, Clinical Infectious Diseases. Oxford University Press, 65(2), pp. 276–281. doi: 10.1093/cid/cix278.   edoc | Open Access
Barda, B., Albonico, M., Buonfrate, D., Ame, S. M., Ali, S., Speich, B. and Keiser, J. (2017) “Side benefits of mass drug administration for lymphatic filariasis on Strongyloides stercoralis prevalence on Pemba Island, Tanzania”, American journal of tropical medicine and hygiene. Williams and Wilkins, 97(3), pp. 681–683. doi: 10.4269/ajtmh.17-0050.   edoc
Abla, N., Keiser, J., Vargas, M., Reimers, N., Haas, H. and Spangenberg, T. (2017) “Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model”, PLoS neglected tropical diseases. Public Library of Science, 11(9), p. e0005942. doi: 10.1371/journal.pntd.0005942.   edoc | Open Access
Kovač, J., Vargas, M. and Keiser, J. (2017) “In vitro and in vivo activity of R- and S- praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel against Schistosoma haematobium”, Parasites and Vectors. BioMed Central, 10, p. 365. doi: 10.1186/s13071-017-2293-3 .   edoc | Open Access
Rajchgot, J., Coulibaly, J. T., Keiser, J., Utzinger, J., Lo, N. C., Mondry, M. K., Andrews, J. R. and Bogoch, I. I. (2017) “Mobile-phone and handheld microscopy for neglected tropical diseases”, PLoS neglected tropical diseases, 11(7), p. e0005550. doi: 10.1371/journal.pntd.0005550 .   edoc | Open Access
Tritten, L., Tam, M., Vargas, M., Jardim, A., Stevenson, M. M., Keiser, J. and Geary, T. G. (2017) “Excretory/secretory products from the gastrointestinal nematode Trichuris muris”, Experimental parasitology, 178, pp. 30–36. doi: 10.1016/j.exppara.2017.05.003.   edoc
Coulibaly, J. T., Panic, G., Silué, K. D., Kovac, J., Hattendorf, H. and Keiser, J. (2017) “Efficacy and safety of praziquantel in preschool-aged and school-aged children infected with Schistosoma mansoni: a randomised controlled, parallel-group, dose-ranging, phase 2 trial”, Lancet Glob Health. Elsevier, 5(7), pp. e688-e698. doi: 10.1016/S2214-109X(17)30187-0.   edoc | Open Access
Greter, H., Cowan, N., Ngandolo, B. N., Kessely, H., Alfaroukh, I. O., Utzinger, J., Keiser, J. and Zinsstag, J. (2017) “Treatment of human and livestock helminth infections in a mobile pastoralist setting at Lake Chad: attitudes to health and analysis of active pharmaceutical ingredients of locally available anthelminthic drugs”, Acta Tropica. Elsevier, 175, pp. 91–99. doi: 10.1016/j.actatropica.2016.05.012.   edoc
Okombo, J., Singh, K., Mayoka, G., Ndubi, F., Barnard, L., Njogu, P. M., Njoroge, M., Gibhard, L., Brunschwig, C., Vargas, M., Keiser, J., Egan, T. J. and Chibale, K. (2017) “Antischistosomal activity of pyrido[1,2-a]benzimidazole derivatives and correlation with inhibition of beta-hematin formation”, ACS Infectious Diseases. American Chemical Society, 3(6), pp. 411–420. doi: 10.1021/acsinfecdis.6b00205.   edoc
Preston, S., Jiao, Y., Baell, J. B., Keiser, J., Crawford, S., Koehler, A. V., Wang, T., Simpson, M. M., Kaplan, R. M., Cowley, K. J., Simpson, K. J., Hofmann, A., Jabbar, A. and Gasser, R. B. (2017) “Screening of the ’Open Scaffolds’ collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber’s pole worm and other parasitic nematodes”, International Journal for Parasitology: Drugs and Drug Resistance. Elsevier, 7(3), pp. 286–294. doi: 10.1016/j.ijpddr.2017.05.004.   edoc
Sayasone, S., Meister, I., Andrews, J. R., Odermatt, P., Vonghachack, Y., Xayavong, S., Senggnam, K., Phongluxa, K., Hattendorf, J., Bogoch, I. I. and Keiser, J. (2017) “Efficacy and safety of praziquantel against light infections of Opisthorchis viverrini : a randomised parallel single blind dose-ranging trial”, Clinical infectious diseases. Oxford University Press, 64(4), pp. 451–458. doi: 10.1093/cid/ciw785.   edoc | Open Access
Cowan, N., Meier, C., Neodo, A. and Keiser, J. (2017) “Exposure of Heligmosomoides polygyrus and Trichuris muris to albendazole, albendazole sulfoxide, mebendazole and oxantel pamoate in vitro and in vivo to elucidate the pathway of drug entry into these gastrointestinal nematodes”, International journal for parasitology. Drugs and drug resistance. Elsevier, 7(2), pp. 159–173. doi: 10.1016/j.ijpddr.2017.03.005.   edoc | Open Access
Bergquist, R., Utzinger, J. and Keiser, J. (2017) “Controlling schistosomiasis with praziquantel : how much longer without a viable alternative?”, Infectious Diseases of Poverty. Biomed Central, 6, p. 74. doi: 10.1186/s40249-017-0286-2.   edoc
Moser, W., Labhardt, N. D., Cheleboi, M., Muhairwe, J. and Keiser, J. (2017) “Unexpected low soil-transmitted helminth prevalence in the Butha-Buthe district in Lesotho, results from a cross-sectional survey”, Parasites and Vectors. BioMed Central, 10, p. 72. doi: 10.1186/s13071-017-1995-x.   edoc
Keiser, J. (2017) “Jennifer Keiser - tackling drug resistance before it arises”, Trends in parasitology. Elsevier, 33(3), pp. 153–154.   edoc
Barda, B., Coulibaly, J. T., Hatz, C. and Keiser, J. (2017) “Ultrasonographic evaluation of urinary tract morbidity in school-aged and preschool-aged children infected with Schistosoma haematobium and its evolution after praziquantel treatment : a randomized controlled trial”, PLoS Neglected Tropical Diseases. Public Library of Science, 11(2), p. e0005400. doi: 10.1371/journal.pntd.0005400.   edoc
Leonidova, A., Vargas, M., Huwyler, J. and Keiser, J. (2016) “Pharmacokinetics of the antischistosomal lead OZ418 in uninfected mice determined by LC-MS/MS”, Antimicrobial agents and chemotherapy. American Society for Microbiology, 60(12), pp. 7364–7371. doi: 10.1128/AAC.02394-15.   edoc
Greter, H., Batil, A. A., Alfaroukh, I. O., Grimm, F., Ngandolo, B. N., Keiser, J., Utzinger, J., Zinsstag, J. and Hattendorf, J. (2016) “Re-infection with Fasciola gigantica 6-months post-treatment with triclabendazole in cattle from mobile pastoralist husbandry systems at Lake Chad”, Veterinary parasitology. Elsevier, 230, pp. 43–48. doi: 10.1016/j.vetpar.2016.10.019.   edoc
Wang, C., Zhao, Q., Vargas, M., Jones, J. O., White, K. L., Shackleford, D. M., Chen, G., Saunders, J., Ng, A. C. F., Chiu, F. C. K., Dong, Y., Charman, S. A., Keiser, J. and Vennerstrom, J. L. (2016) “Revisiting the SAR of the antischistosomal aryl hydantoin (Ro 13-3978)”, Journal of medicinal chemistry. American Chemical Society, 59(23), pp. 10705–10718. doi: 10.1021/acs.jmedchem.6b01410.   edoc | Open Access
Cowan, N., Raimondo, A. and Keiser, J. (2016) “Approved oncology drugs lack in vivo activity against Trichuris muris despite in vitro activity”, Parasitology research. Springer-Verlag, 115(11), pp. 4443–4446. doi: 10.1007/s00436-016-5225-9.   edoc
Duthaler, U., Sayasone, S., Vanobbergen, F., Penny, M. A., Odermatt, P., Huwyler, J. and Keiser, J. (2016) “Single ascending dose pharmacokinetic study of tribendimidine in Opisthorchis viverrini-infected patients”, Antimicrobial agents and chemotherapy. American Society for Microbiology, 60(10), pp. 5705–5715. doi: 10.1128/AAC.00992-16.   edoc
Coulibaly, J. T., Ouattara, M., Keiser, J., Bonfoh, B., N’Goran, E. K., Andrews, J. R. and Bogoch, I. I. (2016) “Evaluation of malaria diagnoses using a handheld light microscope in a community-based setting in rural Côte d’Ivoire”, American journal of tropical medicine and hygiene. Williams and Wilkins, 95(4), pp. 831–834. doi: 10.4269/ajtmh.16-0328.   edoc
Khan, M. O. F., Keiser, J., Amoyaw, P. N. A., Hossain, M. F., Vargas, M., Le, J. G., Simpson, N. C., Roewe, K. D., Freeman, T. N. C., Hasley, T. R., Maples, R. D., Archibald, S. J. and Hubin, T. J. (2016) “Discovery of antischistosomal drug leads based on tetraazamacrocyclic derivatives and their metal complexes”, Antimicrobial agents and chemotherapy. American Society for Microbiology, 60(9), pp. 5331–5336. doi: 10.1128/AAC.00778-16.   edoc
Clède, S., Cowan, N., Lambert, F., Bertrand, H. C., Rubbiani, R., Patra, M., Hess, J., Sandt, C., Trcera, N., Gasser, G., Keiser, J. and Policar, C. (2016) “Bimodal x-ray and infrared imaging of an organometallic derivative of praziquantel in Schistosoma mansoni”, ChemBioChem. Wiley-VCH, 17(11), pp. 1004–1007. doi: 10.1002/cbic.201500688.   edoc
Sayasone, S., Odermatt, P., Vonghachack, Y., Xayavong, S., Senggnam, K., Duthaler, U., Akkhavong, K., Hattendorf, J. and Keiser, J. (2016) “Efficacy and safety of tribendimidine against Opisthorchis viverrini : two randomised, parallel-group, single-blind, dose-ranging, phase 2 trials”, Lancet Infectious Diseases. Elsevier, 16(10), pp. 1145–1453. doi: 10.1016/S1473-3099(16)30198-0.   edoc
Vanobberghen, F., Penny, M. A., Duthaler, U., Odermatt, P., Sayasone, S., Keiser, J. and Tarning, J. (2016) “Population pharmacokinetic modeling of tribendimidine metabolites in opisthorchis viverrini-Infected adults”, Antimicrobial agents and chemotherapy. American Society for Microbiology, 60(10), pp. 5695–5704. doi: 10.1128/AAC.00655-16.   edoc
Van Voorhis, W. C., Adams, J. H., Adelfio, R., Ahyong, V., Akabas, M. H., Alano, P., Alday, A., Alemán Resto, Y., Alsibaee, A., Alzualde, A., Andrews, K. T., Avery, S. V., Avery, V. M., Ayong, L., Baker, M., Baker, S., Ben Mamoun, C., Bhatia, S., Bickle, Q., Bounaadja, L., Bowling, T., Bosch, J., Boucher, L. E., Boyom, F. F., Brea, J., Brennan, M., Burton, A., Caffrey, C. R., Camarda, G., Carrasquilla, M., Carter, D., Belen Cassera, M., Chih-Chien Cheng, K., Chindaudomsate, W., Chubb, A., Colon, B. L., Colón-López, D. D., Corbett, Y., Crowther, G. J., Cowan, N., D’Alessandro, S., Le Dang, N., Delves, M., DeRisi, J. L., Du, A. Y., Duffy, S., Abd El-Salam El-Sayed, S., Ferdig, M. T., Fernández Robledo, J. A., Fidock, D. A., Florent, I., Fokou, P. V. T., Galstian, A., Gamo, F. J., Gokool, S., Gold, B., Golub, T., Goldgof, G. M., Guha, R., Guiguemde, W. A., Gural, N., Guy, R. K., Hansen, M. A. E., Hanson, K. K., Hemphill, A., Hooft van Huijsduijnen, R., Horii, T., Horrocks, P., Hughes, T. B., Huston, C., Igarashi, I., Ingram-Sieber, K., Itoe, M. A., Jadhav, A., Naranuntarat Jensen, A., Jensen, L. T., Jiang, R. H. Y., Kaiser, A., Keiser, J., Ketas, T., Kicka, S., Kim, S., Kirk, K., Kumar, V. P., Kyle, D. E., Lafuente, M. J., Landfear, S., Lee, N., Lee, S., Lehane, A. M., Li, F., Little, D., Liu, L., Llinás, M., Loza, M. I., Lubar, A., Lucantoni, L., Lucet, I., Maes, L., Mancama, D., Mansour, N. R., March, S., McGowan, S., Medina Vera, I., Meister, S., Mercer, L., Mestres, J., Mfopa, A. N., Misra, R. N., Moon, S., Moore, J. P., Morais Rodrigues da Costa, F., Müller, J., Muriana, A., Nakazawa Hewitt, S., Nare, B., Nathan, C., Narraidoo, N., Nawaratna, S., Ojo, K. K., Ortiz, D., Panic, G., Papadatos, G., Parapini, S., Patra, K., Pham, N., Prats, S., Plouffe, D. M., Poulsen, S.-A., Pradhan, A., Quevedo, C., Quinn, R. J., Rice, C. A., Abdo Rizk, M., Ruecker, A., St Onge, R., Salgado Ferreira, R., Samra, J., Robinett, N. G., Schlecht, U., Schmitt, M., Silva Villela, F., Silvestrini, F., Sinden, R., Smith, D. A., Soldati, T., Spitzmüller, A., Stamm, S. M., Sullivan, D. J., Sullivan, W., Suresh, S., Suzuki, B. M., Suzuki, Y., Swamidass, S. J., Taramelli, D., Tchokouaha, L. R. Y., Theron, A., Thomas, D., Tonissen, K. F., Townson, S., Tripathi, A. K., Trofimov, V., Udenze, K. O., Ullah, I., Vallieres, C., Vigil, E., Vinetz, J. M., Voong Vinh, P., Vu, H., Watanabe, N.-A., Weatherby, K., White, P. M., Wilks, A. F., Winzeler, E. A., Wojcik, E., Wree, M., Wu, W., Yokoyama, N., Zollo, P. H. A., Abla, N., Blasco, B., Burrows, J., Laleu, B., Leroy, D., Spangenberg, T., Wells, T. and Willis, P. A. (2016) “Open source drug discovery with the malaria box compound collection for neglected diseases and beyond”, PLoS Pathogens. Public Library of Science, 12(7), p. e1005763. doi: 10.1371/journal.ppat.1005763.   edoc | Open Access
Lo, N. C., Coulibaly, J. T., Bendavid, E., N’Goran, E. K., Utzinger, J., Keiser, J., Bogoch, I. I. and Andrews, J. R. (2016) “Evaluation of a urine pooling strategy for the rapid and cost-efficient prevalence classification of schistosomiasis”, PLoS Neglected Tropical Diseases. Public Library of Science, 10(8), p. e0004894. doi: 10.1371/journal.pntd.0004894.   edoc | Open Access
Coulibaly, J. T., Ouattara, M., Becker, S. L., Lo, N. C., Keiser, J., N’Goran, E. K., Ianniello, D., Rinaldi, L., Cringoli, G. and Utzinger, J. (2016) “Comparison of sensitivity and faecal egg counts of Mini-FLOTAC using fixed stool samples and Kato-Katz technique for the diagnosis of Schistosoma mansoni and soil-transmitted helminths”, Acta tropica. Elsevier Science Publ, 164, pp. 107–116. doi: 10.1016/j.actatropica.2016.08.024.   edoc
Albonico, M., Becker, S. L., Odermatt, P., Angheben, A., Anselmi, M., Amor, A., Barda, B., Buonfrate, D., Cooper, P., Gétaz, L., Keiser, J., Khieu, V., Montresor, A., Muñoz, J., Requena-Méndez, A., Savioli, L., Speare, R., Steinmann, P., van Lieshout, L., Utzinger, J. and Bisoffi, Z. (2016) “StrongNet: An International Network to Improve Diagnostics and Access to Treatment for Strongyloidiasis Control”, PLoS Neglected Tropical Diseases. Public Library of Science, 10(9), p. e0004898. doi: 10.1371/journal.pntd.0004898.   edoc | Open Access
Barda, B., Coulibaly, J. T., Puchkov, M., Huwyler, J., Hattendorf, J. and Keiser, J. (2016) “Efficacy and safety of moxidectin, synriam, synriam-praziquantel versus praziquantel against schistosoma haematobium and S. mansoni infections: a randomized, exploratory phase 2 trial”, PLoS Neglected Tropical Diseases. Public Library of Science, 10(9), p. e0005008. doi: 10.1371/journal.pntd.0005008.   edoc | Open Access
Keiser, J., Panic, G., Adelfio, R., Cowan, N., Vargas, M. and Scandale, I. (2016) “Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections”, Parasites and Vectors. BioMed Central, 9, p. 376. doi: 10.1186/s13071-016-1616-0.   edoc | Open Access
Cordey, S., Brito, F., Vu, D. L., Turin, L., Kilowoko, M., Kyungu, E., Genton, B., Zdobnov, E. M., D’Acremont, V. and Kaiser, L. (2016) “Astrovirus VA1 identified by next-generation sequencing in a nasopharyngeal specimen of a febrile Tanzanian child with acute respiratory disease of unknown etiology”, Emerging microbes and infections. Nature Publishing Group, p. e67. doi: 10.1038/emi.2016.67.   edoc
Coulibaly, J. T., Ouattara, M., D’Ambrosio, M. V., Fletcher, D. A., Keiser, J., Utzinger, J., N’Goran, E. K., Andrews, J. R. and Bogoch, I. I. (2016) “Accuracy of Mobile Phone and Handheld Light Microscopy for the Diagnosis of Schistosomiasis and Intestinal Protozoa Infections in Côte d’Ivoire”, PLoS Neglected Tropical Diseases. Public Library of Science, 10(6), p. e0004768. doi: 10.1371/journal.pntd.0004768.   edoc | Open Access
Meister, I., Kovac, J., Duthaler, U., Odermatt, P., Huwyler, J., Vanobberghen, F., Sayasone, S. and Keiser, J. (2016) “Pharmacokinetic study of praziquantel enantiomers and its main metabolite R-trans-4-OH-PZQ in plasma, blood and dried blood spots in Opisthorchis viverrini-infected patients”, PLoS Neglected Tropical Diseases. Public Library of Science, 10(5), p. e0004700. doi: 10.1371/journal.pntd.0004700.   edoc | Open Access
Qian, M.-B., Utzinger, J., Keiser, J. and Zhou, X.-N. (2016) “Clonorchiasis”, Lancet, 387(10020), pp. 800–810. doi: 10.1016/S0140-6736(15)60313-0.   edoc
Speich, B., Moser, W., Ali, S. M., Ame, S. M., Albonico, M., Hattendorf, J. and Keiser, J. (2016) “Efficacy and reinfection with soil-transmitted helminths 18-weeks post-treatment with albendazole-ivermectin, albendazole-mebendazole, albendazole-oxantel pamoate and mebendazole”, Parasites and Vectors. BioMed Central, 9, p. 123. doi: 10.1186/s13071-016-1406-8.   edoc | Open Access
Meister, I., Leonidova, A., Kovač, J., Duthaler, U., Keiser, J. and Huwyler, J. (2016) “Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots”, Journal of pharmaceutical and biomedical analysis. Elsevier, 118, pp. 81–88. doi: 10.1016/j.jpba.2015.10.011.   edoc
Flores, D., Panic, G., Braissant, O. and Keiser, J. (2016) “A novel isothermal microcalorimetry tool to assess drug effects on Ancylostoma ceylanicum and Necator americanus”, Applied microbiology and biotechnology. Springer, 100(2), pp. 837–846. doi: 10.1007/s00253-015-7081-4.   edoc
Bogoch, I. I., Sayasone, S., Vonghachack, Y., Meister, I., Utzinger, J., Odermatt, P., Andrews, J. R. and Keiser, J. (2016) “Diagnosis of Opisthorchis viverrini infection with handheld microscopy in Lao People’s Democratic Republic”, American journal of tropical medicine and hygiene. Williams and Wilkins, 94(1), pp. 158–160. doi: 10.4269/ajtmh.15-0525.   edoc
Barda, B. D., Keiser, J. and Albonico, M. (2015) “Human trichuriasis : diagnostics update”, Current tropical medicine reports, 2, pp. 201–208. doi: 10.1007/s40475-015-0063-x.   edoc
Panic, G., Flores, D., Ingram-Sieber, K. and Keiser, J. (2015) “Fluorescence/luminescence-based markers for the assessment of Schistosoma mansoni schistosomula drug assays”, Parasites and Vectors. BioMed Central, 8, p. 624. doi: 10.1186/s13071-015-1233-3.   edoc | Open Access
Moser, W., Ali, S. M., Ame, S. M., Speich, B., Puchkov, M., Huwyler, J., Albonico, M., Hattendorf, J. and Keiser, J. (2015) “Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study”, The Lancet infectious diseases. Elsevier, 16(1), pp. 53–60. doi: 10.1016/S1473-3099(15)00271-6.   edoc
Duthaler, U., Keiser, J. and Huwyler, J. (2015) “LC-MS/MS method for the determination of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and dried blood spots”, Journal of pharmaceutical and biomedical analysis. Elsevier, 105, pp. 163–173. doi: 10.1016/j.jpba.2014.12.006.   edoc
Keiser, J. (2015) “Is caenorhabditis elegans the magic bullet for anthelminthic drug discovery?”, Trends in parasitology. Elsevier, Vol. 31, H. 10, pp. 455–456. doi: 10.1016/j.pt.2015.08.004.   edoc
Cowan, N., Yaremenko, I. A., Krylov, I. B., Terent’ev, A. O. and Keiser, J. (2015) “Elucidation of the in vitro and in vivo activities of bridged 1,2,4-trioxolanes, bridged 1,2,4,5-tetraoxanes, tricyclic monoperoxides, silyl peroxides, and hydroxylamine derivatives against Schistosoma mansoni”, Bioorganic & medicinal chemistry. Elsevier, 23(16), pp. 5175–5181. doi: 10.1016/j.bmc.2015.02.010.   edoc | Open Access
Panic, G., Vargas, M., Scandale, I. and Keiser, J. (2015) “Activity profile of an FDA-approved compound library against Schistosoma mansoni”, PLoS neglected tropical diseases. Public Library of Science, Vol. 9, H. 7 , e0003962. doi: 10.1371/journal.pntd.0003962.   edoc | Open Access
Cowan, N. and Keiser, J. (2015) “Repurposing of anticancer drugs: in vitro and in vivo activities against Schistosoma mansoni”, Parasites and Vectors. BioMed Central, 8, p. 417. doi: 10.1186/s13071-015-1023-y.   edoc | Open Access
Ephraim, R. K. D., Duah, E., Cybulski, J. S., Prakash, M., D’Ambrosio, M. V., Fletcher, D. A., Keiser, J., Andrews, J. R. and Bogoch, I. I. (2015) “Diagnosis of Schistosoma haematobium infection with a mobile phone-mounted foldscope and a reversed-lens CellScope in Ghana”, American journal of tropical medicine and hygiene. Williams and Wilkins, Vol. 92, H. 6, pp. 1253–1256. doi: 10.4269/ajtmh.14-0741.   edoc
Vejzagić, N., Adelfio, R., Keiser, J., Kringel, H., Thamsborg, S. M. and Kapel, C. M. O. (2015) “Bacteria-induced egg hatching differs for Trichuris muris and Trichuris suis”, Parasites and Vectors. BioMed Central, 8 (371). doi: 10.1186/s13071-015-0986-z.   edoc | Open Access
Olliaro, P. L., Vaillant, M., Diawara, A., Coulibaly, J. T., Garba, A., Keiser, J., King, C. H., Knopp, S., Landouré, A., N’Goran, E. K., Raso, G., Scherrer, A. U., Sousa-Figueiredo, J. C., Stete, K., Zhou, X.-N. and Utzinger, J. (2015) “Toward measuring Schistosoma response to praziquantel treatment with appropriate descriptors of egg excretion”, PLoS neglected tropical diseases. Public Library of Science, Vol. 9, H. 6 , e0003821. doi: 10.1371/journal.pntd.0003821.   edoc | Open Access
Hess, J., Keiser, J. and Gasser, G. (2015) “Toward organometallic antischistosomal drug candidates”, Future medicinal chemistry. Future Science, Vol. 7, H. 6, pp. 821–830. doi: 10.4155/fmc.15.22.   edoc
Keiser, J., Panic, G., Vargas, M., Wang, C., Dong, Y., Gautam, N. and Vennerstrom, J. L. (2015) “Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal”, The journal of antimicrobial chemotherapy. Academic Press, Vol. 70, H. 6, pp. 1788–1797. doi: 10.1093/jac/dkv016.   edoc
Barda, B., Albonico, M., Ianniello, D., Ame, S. M., Keiser, J., Speich, B., Rinaldi, L., Cringoli, G., Burioni, R., Montresor, A. and Utzinger, J. (2015) “How long can stool samples be fixed for an accurate diagnosis of soil-transmitted helminth infection using mini-FLOTAC?”, PLoS neglected tropical diseases. Public Library of Science, Vol. 9, H. 4 , e0003698. doi: 10.1371/journal.pntd.0003698.   edoc | Open Access
Ogorodova, L. M., Fedorova, O. S., Sripa, B., Mordvinov, V. A., Katokhin, A. V., Keiser, J., Odermatt, P., Brindley, P. J., Mayboroda, O. A., Velavan, T. P., Freidin, M. B., Sazonov, A. E., Saltykova, I. V., Pakharukova, M. Y., Kovshirina, Y. V., Kaloulis, K., Krylova, O. Y., Yazdanbakhsh, M. and Topic Consortium (2015) “Opisthorchiasis: an overlooked danger”, PLoS neglected tropical diseases. Public Library of Science, Vol. 9, H. 4 , e0003563. doi: 10.1371/journal.pntd.0003563.   edoc | Open Access
Speich, B., Ali, S. M., Ame, S. M., Albonico, M., Utzinger, J. and Keiser, J. (2015) “Quality control in the diagnosis of Trichuris trichiura and Ascaris lumbricoides using the Kato-Katz technique : experience from three randomised controlled trials”, Parasites and Vectors. BioMed Central, 8 (82). doi: 10.1186/s13071-015-0702-z.   edoc | Open Access
Keiser, J. and [et al.] (2015) “Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infection : a four-arm, randomised controlled trial”, The Lancet infectious diseases. Elsevier, Vol. 15, H. 3, pp. 277–284. doi: 10.1016/S1473-3099(14)71050-3.   edoc
Braissant, O., Keiser, J., Meister, I., Bachmann, A., Wirz, D., Göpfert, B., Bonkat, G. and Wadsö, I. (2015) “Isothermal microcalorimetry accurately detects bacteria, tumorous microtissues, and parasitic worms in a label-free well-plate assay”, Biotechnology journal. Wiley, 10(3), pp. 460–468. doi: 10.1002/biot.201400494.   edoc
Kljun, J., Scott, A. J., Rizner, T. L., Keiser, J. and Turel, I. (2014) “Synthesis and biological evaluation of organoruthenium complexes with azole antifungal agents : first crystal structure of a tioconazole metal complex”, Organometallics. American Chemical Society, Vol. 33, H. 7, pp. 1594–1601.   edoc
Kulke, D., von Samson-Himmelstjerna, G., Miltsch, S. M., Wolstenholme, A. J., Jex, A. R., Gasser, R. B., Ballesteros, C., Geary, T. G., Keiser, J., Townson, S., Harder, A. and Krücken, J. (2014) “Characterization of the Ca2+-gated and voltage-dependent k+-channel slo-1 of nematodes and its interaction with emodepside”, PLoS neglected tropical diseases. Public Library of Science, Vol. 8, H. 12 , e3401. doi: 10.1371/journal.pntd.0003401.   edoc | Open Access
Spivak, A. Y., Keiser, J., Vargas, M., Gubaidullin, R. R., Nedopekina, D. A., Shakurova, E. R., Khalitova, R. R. and Odinokov, V. N. (2014) “Synthesis and activity of new triphenylphosphonium derivatives of betulin and betulinic acid against Schistosoma mansoni in vitro and in vivo”, Bioorganic & medicinal chemistry. Elsevier, 22(21), pp. 6297–6304. doi: 10.1016/j.bmc.2014.07.014.   edoc
Bogoch, I. I., Andrews, J. R., Speich, B., Ame, S. M., Ali, S. M., Stothard, J. R., Utzinger, J. and Keiser, J. (2014) “Quantitative evaluation of a handheld light microscope for field diagnosis of soil-transmitted helminth infection”, American journal of tropical medicine and hygiene. Williams and Wilkins, Vol. 91, H. 6, pp. 1138–1141. doi: 10.4269/ajtmh.14-0253.   edoc
Bogoch, I. I., Coulibaly, J. T., Andrews, J. R., Speich, B., Keiser, J., Stothard, J. R., N’goran, E. K. and Utzinger, J. (2014) “Evaluation of portable microscopic devices for the diagnosis of Schistosoma and soil-transmitted helminth infection”, Parasitology. Cambridge University Press, Vol. 141, H. 14, pp. 1811–1818. doi: 10.1017/S0031182014000432.   edoc
Panic, G., Duthaler, U., Speich, B. and Keiser, J. (2014) “Repurposing drugs for the treatment and control of helminth infections”, International journal of parasitology : drugs and drug resistance. Elsevier], Vol. 4, pp. 185–200. doi: 10.1016/j.ijpddr.2014.07.002.   edoc
Wang, C., Zhao, Q., Min, J., Muniyan, S., Vargas, M., Wang, X., Dong, Y., Guy, R. K., Lin, M.-F., Keiser, J. and Vennerstrom, J. L. (2014) “Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978”, American journal of tropical medicine and hygiene. Williams and Wilkins, Vol. 90, H. 6, pp. 1156–1158. doi: 10.4269/ajtmh.14-0029.   edoc
Meister, I., Ingram-Sieber, K., Cowan, N., Todd, M., Robertson, M. N., Meli, C., Patra, M., Gasser, G. and Keiser, J. (2014) “Activity of praziquantel enantiomers and main metabolites against Schistosoma mansoni”, Antimicrobial agents and chemotherapy. American Society for Microbiology, Vol. 58, H. 9, pp. 5466–5472. doi: 10.1128/AAC.02741-14.   edoc
Tritten, L., Keiser, J., Karwa, T., Utzinger, J., Holmes, E. and Saric, J. (2014) “Comparing systemic metabolic responses in mice to single or dual infection with Plasmodium berghei and Heligmosomoides bakeri”, Molecular biosystems. Royal Society of Chemistry, Vol. 10, H. 9, pp. 2358–2367. doi: 10.1039/c4mb00097h.   edoc
Keiser, J., Vargas, M., Rubbiani, R., Gasser, G. and Biot, C. (2014) “In vitro and in vivo antischistosomal activity of ferroquine derivatives”, Parasites and Vectors. BioMed Central, 7 (424). doi: 10.1186/1756-3305-7-424.   edoc | Open Access
Keiser, J., Silué, K. D., Adiossan, L. K., N’Guessan, N. A., Monsan, N., Utzinger, J. and N’Goran, E. K. (2014) “Praziquantel, mefloquine-praziquantel, and mefloquine-artesunate-praziquantel against Schistosoma haematobium : a randomized, exploratory, open-label trial”, PLoS neglected tropical diseases. Public Library of Science, Vol. 8, H. 7 , e2975. doi: 10.1371/journal.pntd.0002975.   edoc | Open Access
Speich, B., Utzinger, J., Marti, H., Ame, S. M., Ali, S. M., Albonico, M. and Keiser, J. (2014) “Comparison of the Kato-Katz method and ether-concentration technique for the diagnosis of soil-transmitted helminth infections in the framework of a randomised controlled trial”, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. Springer, Vol. 33, H. 5, pp. 815–822. doi: 10.1007/s10096-013-2019-1.   edoc
Ingram-Sieber, K., Cowan, N., Panic, G., Vargas, M., Mansour, N. R., Bickle, Q. D., Wells, T. N. C., Spangenberg, T. and Keiser, J. (2014) “Orally active antischistosomal early leads identified from the open access malaria box”, PLoS neglected tropical diseases. Public Library of Science, Vol. 8, H. 1 , e2610. doi: 10.1371/journal.pntd.0002610.   edoc | Open Access
Küster, T., Kriegel, N., Stadelmann, B., Wang, X., Dong, Y., Vennerstrom, J. L., Keiser, J. and Hemphill, A. (2014) “Amino ozonides exhibit in vitro activity against Echinococcus multilocularis metacestodes”, International journal of antimicrobial agents. Elsevier, Vol. 43, H. 1, pp. 40–46. doi: 10.1016/j.ijantimicag.2013.09.012.   edoc
Olliaro, P., Delgado-Romero, P. and Keiser, J. (2014) “The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer)”, The journal of antimicrobial chemotherapy. Academic Press, Vol. 69, H. 4, pp. 863–870. doi: 10.1093/jac/dkt491.   edoc
Keiser, J., Speich, B. and Utzinger, J. (2014) “The authors reply : Yasukawa K. comment to ‘Oxantel pamoate-albendazole for Trichuris trichiura infection’”, The New England journal of medicine. Massachusetts Medical Society, p. 1953. doi: 10.1056/NEJMc1403068.   edoc
Speich, B., Ame, S. M., Ali, S. M., Alles, R., Huwyler, J., Hattendorf, J., Utzinger, J., Albonico, M. and Keiser, J. (2014) “Oxantel pamoate-albendazole for Trichuris trichiura infection”, The New England journal of medicine. Massachusetts Medical Society, Vol. 370, H. 7, pp. 610–620. doi: 10.1056/NEJMoa1301956.   edoc
Qian, M. B., Yap, P., Yang, Y. C., Liang, H., Jiang, Z. H., Li, W., Utzinger, J., Zhou, X. N. and Keiser, J. (2013) “Accuracy of the Kato-Katz method and formalin-ether concentration technique for the diagnosis of Clonorchis sinensis, and implication for assessing drug efficacy”, Parasites and Vectors. BioMed Central, 6 (314). doi: 10.1186/1756-3305-6-314.   edoc | Open Access
Utzinger, J. and Keiser, J. (2013) “Research and development for neglected diseases : more is still needed, and faster”, Lancet global health. Elsevier], Vol. 1, H. 6 , e317-e318. doi: 10.1016/S2214-109X(13)70148-7.   edoc
Patra, M., Joshi, T., Pierroz, V., Ingram, K., Kaiser, M., Ferrari, S., Spingler, B., Keiser, J. and Gasser, G. (2013) “DMSO-mediated ligand dissociation : renaissance for biological activity of N-heterocyclic-[Ru(η(6) -arene)Cl2 ] drug candidates”, Chemistry : a European journal. Wiley-VCH Verlag, Vol. 19, H. 44, pp. 14768–14772. doi: 10.1002/chem.201303341.   edoc
Panic, G., Ingram, K. and Keiser, J. (2013) “Development of an in vitro drug sensitivity assay based on newly excysted larvae of Echinostoma caproni”, Parasites and Vectors. BioMed Central, 6 (237). doi: 10.1186/1756-3305-6-237.   edoc | Open Access
Alles, R., Puchkov, M., Jablonski, C., Speich, B., Keiser, J. and Huwyler, J. (2013) “Development of oxantel tablets for pediatric clinical studies : a technical note”, Journal of drug delivery science and technology. Ed. de Santé, Vol. 23, H. 6, pp. 623–625.   edoc
Patra, M., Ingram, K., Leonidova, A., Pierroz, V., Ferrari, S., Robertson, M. N., Todd, M. H., Keiser, J. and Gasser, G. (2013) “In vitro metabolic profile and in vivo antischistosomal activity studies of (η(6)-praziquantel)Cr(CO)3 derivatives”, Journal of medicinal chemistry. American Chemical Society, 56(22), pp. 9192–9198. doi: 10.1021/jm401287m.   edoc | Open Access
Tritten, L., Keiser, J., Godejohann, M., Utzinger, J., Vargas, M., Beckonert, O., Holmes, E. and Saric, J. (2013) “Metabolic profiling framework for discovery of candidate diagnostic markers of malaria”, Scientific Reports. Nature Publishing Group, 3, p. 2769. doi: 10.1038/srep02769.   edoc | Open Access
Knopp, S., Becker, S. L., Ingram, K. J., Keiser, J. and Utzinger, J. (2013) “Diagnosis and treatment of schistosomiasis in children in the era of intensified control”, Expert review of anti-infective therapy. Expert Reviews, Vol. 11, H. 11, pp. 1237–1258. doi: 10.1586/14787210.2013.844066.   edoc
Tsang, A. S., Ingram, K., Keiser, J., Hibbert, D. B. and Todd, M. H. (2013) “Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group”, Organic & biomolecular chemistry : an international journal of synthetic, physical and biomolecular organic chemistry. Royal Society of Chemistry, pp. 4921–4924. doi: 10.1039/c3ob40503f.   edoc
Meister, I., Duthaler, U., Huwyler, J., Rinaldi, L., Bosco, A., Cringoli, G. and Keiser, J. (2013) “Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with Fasciola hepatica in sheep”, Veterinary parasitology. Elsevier, Vol. 198, H. 1-2, pp. 102–110. doi: 10.1016/j.vetpar.2013.08.007.   edoc
Ingram, K., Duthaler, U., Vargas, M., Ellis, W. and Keiser, J. (2013) “Disposition of mefloquine and enpiroline is highly influenced by a chronic Schistosoma mansoni infection”, Antimicrobial agents and chemotherapy. American Society for Microbiology, Vol. 57, H. 9, pp. 4506–4511. doi: 10.1128/AAC.01129-13.   edoc
Keiser, J., Adelfio, R., Vargas, M., Odermatt, P. and Tesana, S. (2013) “Activity of tribendimidine and praziquantel combination therapy against the liver fluke Opisthorchis viverrini in vitro and in vivo”, Journal of helminthology. Cambridge University Press, Vol. 87, H. 2, pp. 252–256.   edoc
Vukcevic, M., Zorzato, F., Keck, S., Tsakiris, D. A., Keiser, J., Maizels, R. M. and Treves, S. (2013) “Gain of function in the immune system caused by a ryanodine receptor 1 mutation”, Journal of cell science. Company of Biologists, 126(15), pp. 3485–3492. doi: 10.1242/jcs.130310.   edoc | Open Access
Qian, M. B., Yap, P., Yang, Y. C., Liang, H., Jiang, Z. H., Li, W., Tan, Y. G., Zhou, H., Utzinger, J., Zhou, X. N. and Keiser, J. (2013) “Efficacy and safety of tribendimidine against Clonorchis sinensis”, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. Oxford University Press, Vol. 56, H. 7 , e76-e82. doi: 10.1093/cid/cis1011.   edoc
Bogoch, I. I., Andrews, J. R., Speich, B., Utzinger, J., Ame, S. M., Ali, S. M. and Keiser, J. (2013) “Mobile phone microscopy for the diagnosis of soil-transmitted helminth infections : a Proof-of-Concept Study”, American journal of tropical medicine and hygiene. Williams and Wilkins, Vol. 88, H. 4, pp. 626–629. doi: 10.4269/ajtmh.12-0742.   edoc
Xiao, S.-H., Utzinger, J., Tanner, M., Keiser, J. and Xue, J. (2013) “Advances with the Chinese anthelminthic drug tribendimidine in clinical trials and laboratory investigations”, Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin. Elsevier Science Publ, 126(2), pp. 115–126. doi: 10.1016/j.actatropica.2013.01.009.   edoc
Wimmersberger, D., Tritten, L. and Keiser, J. (2013) “Development of an in vitro drug sensitivity assay for Trichuris muris first-stage larvae”, Parasites and Vectors. BioMed Central, 6 (42). doi: 10.1186/1756-3305-6-42.   edoc | Open Access
Keiser, J., Manneck, T., Kirchhofer, C. and Braissant, O. (2013) “Isothermal microcalorimetry to study the activity of triclabendazole and its metabolites on juvenile and adult Fasciola hepatica”, Experimental parasitology : EP. Academic Press, Vol. 133, H. 3, pp. 265–268. doi: 10.1016/j.exppara.2012.11.020.   edoc
Speich, B., Marti, H., Ame, S. M., Ali, S. M., Bogoch, I. I., Utzinger, J., Albonico, M. and Keiser, J. (2013) “Prevalence of intestinal protozoa infection among school-aged children on Pemba Island, Tanzania, and effect of single-dose albendazole, nitazoxanide and albendazole-nitazoxanide”, Parasites and Vectors. BioMed Central, 6 (3). doi: 10.1186/1756-3305-6-3.   edoc | Open Access
de Moraes, J., Keiser, J., Ingram, K., Nascimento, C., Yamaguchi, L. F., Bittencourt, C. R., Bemquerer, M. P., Leite, J. R., Kato, M. J. and Nakano, E. (2013) “In vitro synergistic interaction between amide piplartine and antimicrobial peptide dermaseptin against Schistosoma mansoni schistosomula and adult worms”, Current medicinal chemistry. Bentham, Vol. 20, H. 2, pp. 301–309.   edoc
Patra, M., Ingram, K., Pierroz, V., Ferrari, S., Spingler, B., Gasser, R. B., Keiser, J. and Gasser, G. (2013) “[(η(6) -praziquantel)Cr(CO)(3)] derivatives with remarkable in vitro anti-schistosomal activity”, Chemistry : a European journal. Wiley-VCH Verlag, Vol. 19, H. 7, pp. 2232–2235. doi: 10.1002/chem.201204291.   edoc
Keiser, J., Tritten, L., Silbereisen, A., Speich, B., Adelfio, R. and Vargas, M. (2013) “Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms : revival of an old drug”, PLoS neglected tropical diseases. Public Library of Science, Vol. 7, H. 3 , e2119. doi: 10.1371/journal.pntd.0002119.   edoc | Open Access
Ziegelbauer, K., Speich, B., Mäusezahl, D., Bos, R., Keiser, J. and Utzinger, J. (2012) “Effect of sanitation on soil-transmitted helminth infection : systematic review and meta-analysis”, PLoS medicine. PLoS. doi: 10.1371/journal.pmed.1001162.   edoc | Open Access
Soukhathammavong, P. A., Sayasone, S., Phongluxa, K., Xayaseng, V., Utzinger, J., Vounatsou, P., Hatz, C., Akkhavong, K., Keiser, J. and Odermatt, P. (2012) “Low efficacy of single-dose albendazole and mebendazole against hookworm and effect on concomitant helminth infection in Lao PDR”, PLoS neglected tropical diseases. Public Library of Science, Vol. 6, H. 1 , e1417. doi: 10.1371/journal.pntd.0001417.   edoc | Open Access
Caffrey, C. R., Utzinger, J. and Keiser, J. (2012) “Drug discovery for trematodiases : challenges and progress”, in Parasitic helminths : targets, screens, drugs and vaccines. Weinheim: Wiley Blackwell (Drug discovery in infectious diseases), pp. 323–337.   edoc
Lovis, L., Mak, T. K., Phongluxa, K., Soukhathammavong, P. A., Vonghachack, Y., Keiser, J., Vounatsou, P., Tanner, M., Hatz, C., Utzinger, J., Odermatt, P. and Akkhavong, K. (2012) “Efficacy of praziquantel against Schistosoma mekongi and Opisthorchis viverrini : a randomized, single-blinded dose-comparison trial”, PLoS neglected tropical diseases. Public Library of Science, Vol. 6, H. 7 , e1726. doi: 10.1371/journal.pntd.0001726.   edoc | Open Access
Koné, W. M., Vargas, M. and Keiser, J. (2012) “Anthelmintic activity of medicinal plants used in Côte d’Ivoire for treating parasitic diseases”, Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie. Springer-Verlag, Vol. 110, H. 6, pp. 2351–2362. doi: 10.1007/s00436-011-2771-z.   edoc
Keiser, J. and Utzinger, J. (2012) “Antimalarials in the treatment of schistosomiasis”, Current pharmaceutical design. Bentham Science Publ, Vol. 18, H. 24, pp. 3531–3538. doi: 10.2174/138161212801327293.   edoc
Tritten, L., Silbereisen, A. and Keiser, J. (2012) “Nitazoxanide : in vitro and in vivo drug effects against Trichuris muris and Ancylostoma ceylanicum, alone or in combination”, International journal for parasitology: drugs and drug resistance. Elsevier, Vol. 2, pp. 98–105. doi: 10.1016/j.ijpddr.2012.02.004.   edoc
Ingram, K., Ellis, W. and Keiser, J. (2012) “Antischistosomal activities of mefloquine-related arylmethanols”, Antimicrobial agents and chemotherapy. American Society for Microbiology, Vol. 56, H. 6, pp. 3207–3215. doi: 10.1128/AAC.06177-11.   edoc
Manneck, T., Keiser, J. and Müller, J. (2012) “Mefloquine interferes with glycolysis in schistosomula of Schistosoma mansoni via inhibition of enolase”, Parasitology. Cambridge University Press, Vol. 139, H. 4, pp. 497–505. doi: 10.1017/S0031182011002204.   edoc
Zumla, A. and Keiser, J. (2012) “Tropical diseases”, Infectious disease clinics of North America. doi: 10.1016/j.idc.2012.03.012.   edoc
Saric, J., Want, E. J., Duthaler, U., Lewis, M., Keiser, J., Schockcor, J. P., Ross, G. A., Nicholson, J. K., Holmes, E. and Tavares, M. F. (2012) “Systematic evaluation of extraction methods for multi-platform based metabotyping : application to the Fasciola hepatica metabolome”, Analytical chemistry. American Chemical Society, Vol. 84, H. 16, pp. 6963–6972. doi: 10.1021/ac300586m.   edoc
Coulibaly, J. T., N’Gbesso, Y. K., Knopp, S., Keiser, J., N’Goran, E. K. and Utzinger, J. (2012) “Efficacy and safety of praziquantel in preschool-aged children in an area co-endemic for Schistosoma mansoni and S. haematobium”, PLoS neglected tropical diseases. Public Library of Science, Vol. 6, H. 12 , e1917. doi: 10.1371/journal.pntd.0001917.   edoc | Open Access
Thomsen, H., Reider, K., Franke, K., Wessjohann, L. A., Keiser, J., Dagne, E. and Arnold, N. (2012) “Characterization of constituents and anthelmintic properties of Hagenia abyssinica”, Scientia Pharmaceutica. Österreichischer Apotheker-Verlag, 80(2), pp. 433–446. doi: 10.3797/scipharm.1109-04.   edoc | Open Access
Tritten, L., Braissant, O. and Keiser, J. (2012) “Comparison of novel and existing tools for studying drug sensitivity against the hookworm Ancylostoma ceylanicum in vitro”, Parasitology. Cambridge University Press, Vol. 139, H. 3, pp. 348–357. doi: 10.1017/S0031182011001934.   edoc
Marxer, M., Ingram, K. and Keiser, J. (2012) “Development of an in vitro drug screening assay using Schistosoma haematobium schistosomula”, Parasites and Vectors. BioMed Central, 5 (164). doi: 10.1186/1756-3305-5-165.   edoc | Open Access
Ingram, K., Schiaffo, C. E., Sittiwong, W., Benner, E., Dussault, P. H. and Keiser, J. (2012) “In vitro and in vivo activity of 3-alkoxy-1,2-dioxolanes against Schistosoma mansoni”, The journal of antimicrobial chemotherapy. Academic Press, Vol. 67, H. 8, pp. 1979–1986. doi: 10.1093/jac/dks141.   edoc
Keiser, J., Tritten, L., Adelfio, R. and Vargas, M. (2012) “Effect of combinations of marketed human anthelmintic drugs against Trichuris muris in vitro and in vivo”, Parasites and Vectors. BioMed Central, 5(292). doi: 10.1186/1756-3305-5-292.   edoc | Open Access
Tritten, L., Nwosu, U., Vargas, M. and Keiser, J. (2012) “In vitro and in vivo efficacy of tribendimidine and its metabolites alone and in combination against the hookworms Heligmosomoides bakeri and Ancylostoma ceylanicum”, Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin. Elsevier Science Publ, 122(1), pp. 101–107. doi: 10.1016/j.actatropica.2011.12.008.   edoc | Open Access
Keiser, J., Vargas, M. and Winter, R. (2012) “Anthelminthic properties of mangostin and mangostin diacetate”, Parasitology international. Elsevier, Vol. 61, H. 2, pp. 369–371. doi: 10.1016/j.parint.2012.01.004.   edoc
Patra, M., Ingram, K., Pierroz, V., Ferrari, S., Spingler, B., Keiser, J. and Gasser, G. (2012) “Ferrocenyl derivatives of the anthelmintic praziquantel : design, synthesis and biological evaluation”, Journal of medicinal chemistry. American Chemical Society, 55(20), pp. 8790–8798. doi: 10.1021/jm301077m.   edoc | Open Access
Utzinger, J., Becker, S. L., Knopp, S., Blum, J., Neumayr, A. L., Keiser, J. and Hatz, C. F. (2012) “Neglected tropical diseases : diagnosis, clinical management, treatment and control”, Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology. EMH, Vol. 142 , w13726. doi: 10.4414/smw.2012.13727.   edoc | Open Access
Knopp, S., Steinmann, P., Keiser, J. and Utzinger, J. (2012) “Nematode infections : soil-transmitted helminths and Trichinella”, Infectious disease clinics of North America, Vol. 26, H. 2, pp. 341–358. doi: 10.1016/j.idc.2012.02.006.   edoc
Ingram, K., Yaremenko, I. A., Krylov, I., Hofer, L., Terent’ev, A. O. and Keiser, J. (2012) “Identification of antischistosomal leads by evaluating peroxides of beta-dicarbonyl compounds and their heteroanalogs : bridged 1,2,4,5-tetraoxanes and alphaperoxides, and beta,delta-triketones: tricyclic monoperoxides”, Journal of medicinal chemistry. American Chemical Society, 55(20), pp. 8700–8711. doi: 10.1021/jm3009184.   edoc | Open Access
Lochmatter, C., Schneider, C. L., Ingram, K., Keiser, J. and Schifferli, J. A. (2012) “Schistosoma mansoni tetraspanning orphan receptor (SmTOR) : a new vaccine candidate against Schistosomiasis”, Clinical and experimental immunology. Blackwell, Vol. 170, H. 3, pp. 342–357. doi: 10.1111/j.1365-2249.2012.04667.x.   edoc
Speich, B., Ame, S. M., Ali, S. M., Alles, R., Hattendorf, J., Utzinger, J., Albonico, M. and Keiser, J. (2012) “Efficacy and safety of nitazoxanide, albendazole, and nitazoxanide-albendazole against Trichuris trichiura infection : a randomized controlled trial”, PLoS neglected tropical diseases. Public Library of Science, Vol. 6, H. 6 , e1685. doi: 10.1371/journal.pntd.0001685.   edoc | Open Access
Keiser, J., Ingram, K., Vargas, M., Chollet, J., Wang, X., Dong, Y. and Vennerstrom, J. L. (2012) “In vivo activity of aryl ozonides against Schistosoma species”, Antimicrobial agents and chemotherapy. American Society for Microbiology, Vol. 56, H. 2, pp. 1090–1092. doi: 10.1128/AAC.05371-11.   edoc
Toyang, N. J., Ateh, E. N., Keiser, J., Vargas, M., Bach, H., Tane, P., Sondengam, L. B., Davis, H., Bryant, J. and Verpoorte, R. (2012) “Toxicity, antimicrobial and anthelmintic activities of Vernonia guineensis Benth. (Asteraceae) crude extracts”, Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs. Elsevier Scientific Publishers, Vol. 144, H. 3, pp. 700–704. doi: 10.1016/j.jep.2012.10.016.   edoc
Knopp, S., Steinmann, P., Hatz, C., Keiser, J. and Utzinger, J. (2012) “Nematode infections : filariases”, Infectious disease clinics of North America, Vol. 26, H. 2, pp. 359–381. doi: 10.1016/j.idc.2012.02.005.   edoc
Kirchhofer, C., Vargas, M., Huwyler, J. and Keiser, J. (2012) “Pharmacokinetics of the fasciocidal drug candidates MT04 and OZ78 in uninfected rats and in vitro pharmacodynamic studies”, International journal for parasitology: drugs and drug resistance. Elsevier, Vol. 2, pp. 121–125. doi: 10.1016/j.ijpddr.2012.03.003.   edoc
Duthaler, U., Huwyler, J., Rinaldi, L., Cringoli, G. and Keiser, J. (2012) “Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with Fasciola hepatica”, Veterinary parasitology. Elsevier, Vol. 186, H. 3-4, pp. 270–280. doi: 10.1016/j.vetpar.2011.11.076.   edoc
Keiser, J., Ingram, K., Vargas, M., Chollet, J., Wang, X., Dong, Y. and Vennerstrom, J. L. (2011) “In vivo activity of next generation synthetic ozonides against Schistosoma species”, Antimicrobial agents and chemotherapy. American Society for Microbiology, 56(2), pp. 1090–1092. doi: 10.1128/AAC.05371-11.   edoc
Keiser, J. and Utzinger, J. (2011) “Foodborne trematodiasis and schistosomiasis”, in Rudolph, C., Rudolph, A., Lister, G., First, L., and Gershon, A. (eds.) Rudolph’s Pediatrics. New York: McGraw-Hill, pp. 1200–1203.   edoc
Jones, M. K., Keiser, J. and McManus, D. P. (2011) “Trematodes”, in Jorgensen, J. H. (ed.) Manual of clinical microbiology. Washington: ASM Press, pp. 2230–2242.   edoc
Stadelmann, B., Küster, T., Scholl, S., Barna, F., Kropf, C., Keiser, J., Boykin, D. W., Stephens, C. E. and Hemphill, A. (2011) “In vitro efficacy of dicationic compounds and mefloquine enantiomers against Echinococcus multilocularis metacestodes”, Antimicrobial agents and chemotherapy : AAC. American Society for Microbiology, Vol. 55, H. 10, pp. 4866–4872. doi: 10.1128/AAC.00478-11.   edoc
Utzinger, J., N’Goran E. K., Caffrey, C. R. and Keiser, J. (2011) “From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis”, Acta tropica. Elsevier Science Publ, 120(1), pp. S121-S137. doi: 10.1016/j.actatropica.2010.08.020.   edoc
Keiser, J., Sayed, H., El-Ghanam M., Sabry, H., Anani, S., El-Wakeel A., Hatz, C., Utzinger, J., El-Din S. S., El-Maadawy W. and Botros, S. (2011) “Efficacy and safety of artemether in the treatment of chronic fascioliasis in Egypt: exploratory phase-2 trials”, PLoS neglected tropical diseases. Library of Science, Vol. 5, H. 9 , e1285. doi: 10.1371/journal.pntd.0001285.   edoc
Kirchhofer, C., Vargas, M., Braissant, O., Dong, Y., Wang, X., Vennerstrom, J. L. and Keiser, J. (2011) “Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni”, Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin. Elsevier Science Publ, 118(1), pp. 56–62. doi: 10.1016/j.actatropica.2011.02.003.   edoc | Open Access
Manneck, T., Braissant, O., Ellis, W. and Keiser, J. (2011) “Schistosoma mansoni: antischistosomal activity of the four optical isomers and the two racemates of mefloquine on schistosomula and adult worms in vitro and in vivo”, Experimental parasitology : EP. Academic Press, Vol. 127, H. 1, pp. 260–269. doi: 10.1016/j.exppara.2010.08.011.   edoc
Manneck, T., Braissant, O., Haggenmüller, Y. and Keiser, J. (2011) “Isothermal microcalorimetry to study drugs against Schistosoma mansoni”, Journal of clinical microbiology, Vol. 49, H. 4, pp. 1217–1225. doi: 10.1128/JCM.02382-10.   edoc
Küster, T., Stadelmann, B., Hermann, C., Scholl, S., Keiser, J. and Hemphill, A. (2011) “In vitro and in vivo efficacy of mefloquine-based treatment against alveolar echinococcosis”, Antimicrobial agents and chemotherapy : AAC. American Society for Microbiology, Vol. 55, H. 2, pp. 713–721. doi: 10.1128/AAC.01392-10.   edoc
Keiser, J., Ingram, K. and Utzinger, J. (2011) “Antiparasitic drugs for paediatrics : systematic review, formulations, pharmacokinetics, safety, efficacy and implications for control”, Parasitology. Cambridge University Press, Vol. 138, H. 12, pp. 1620–1632. doi: 10.1017/S0031182011000023.   edoc
Wang, X., Zhao, Q., Vargas, M., Dong, Y., Sriraghavan, K., Keiser, J. and Vennerstrom, J. L. (2011) “The activity of dispiro peroxides against Fasciola hepatica”, Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines. Pergamon, Vol. 21, H. 18, pp. 5320–5330. doi: 10.1016/j.bmcl.2011.07.024.   edoc
Silbereisen, A., Tritten, L. and Keiser, J. (2011) “Exploration of novel in vitro assays to study drugs against Trichuris spp”, Journal of microbiological methods. Elsevier, Vol. 87, H. 2, pp. 169–175. doi: 10.1016/j.mimet.2011.08.009.   edoc
Olliaro, P., Seiler, J., Kuesel, A., Horton, J., Clark, J. N., Don, R. and Keiser, J. (2011) “Potential drug development candidates for human soil-transmitted helminthiases”, PLoS neglected tropical diseases. Library of Science, Vol. 5, H. 6 , e1138. doi: 10.1371/journal.pntd.0001138.   edoc
Keiser, J., Manneck, T. and Vargas, M. (2011) “Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitro”, The journal of antimicrobial chemotherapy. Academic Press, Vol. 66, H. 8, pp. 1791–1797. doi: 10.1093/jac/dkr178.   edoc
Nwosu, U., Vargas, M., Harder, A. and Keiser, J. (2011) “Efficacy of the cyclooctadepsipeptide PF1022A against Heligmosomoides bakeri in vitro and in vivo”, Parasitology. Cambridge University Press, Vol. 138, H. 9, pp. 1193–1201. doi: 10.1017/S003118201100076X.   edoc
Tritten, L., Silbereisen, A. and Keiser, J. (2011) “In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections”, PLoS neglected tropical diseases. Library of Science, Vol. 5, H. 12 , e1457. doi: 10.1371/journal.pntd.0001457.   edoc
Ferreira, J. F., Peaden, P. and Keiser, J. (2011) “In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis : trematocidal plant alcoholic extracts”, Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie. Springer-Verlag, Vol. 109, H. 6, pp. 1585–1592. doi: 10.1007/s00436-011-2418-0.   edoc
Li, J. V., Saric, J., Wang, Y., Keiser, J., Utzinger, J. and Holmes, E. (2011) “Chemometric analysis of biofluids from mice experimentally infected with Schistosoma mansoni”, Parasites and Vectors. BioMed Central, 4 (179). doi: 10.1186/1756-3305-4-179.   edoc | Open Access
Soukhathammavong, P., Odermatt, P., Sayasone, S., Vonghachack, Y., Vounatsou, P., Hatz, C., Akkhavong, K. and Keiser, J. (2011) “Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini : a randomised, exploratory, open-label, phase 2 trial”, The Lancet infectious diseases. Elsevier, 11(2), pp. 110–118. doi: 10.1016/S1473-3099(10)70250-4.   edoc | Open Access
Duthaler, U., Keiser, J. and Huwyler, J. (2011) “Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether, and their major metabolites dihydroartemisinin and dihydroartemisininglucuronide in sheep plasma”, Journal of Mass Spectrometry. Wiley, 46(2), pp. 172–181. doi: 10.1002/jms.1883.   edoc
Keiser, J. and Utzinger, J. (2010) “The drugs we have and the drugs we need against major helminth infections”, Advances in parasitology. Elsevier, Vol. 73, pp. 197–230.   edoc
Keiser, J. (2010) “In vitro and in vivo trematode models for chemotherapeutic studies”, Parasitology. Cambridge University Press, 137(3), pp. 589–603.   edoc
Keiser, J., Duthaler, U. and Utzinger, J. (2010) “Update on the diagnosis and treatment of food-borne trematode infections”, Current opinion in infectious diseases. Lippincott Williams & Wilkins, 23(5), pp. 513–520.   edoc
Utzinger, J., Steinmann, P., Keiser, J. and Bos, R. (2010) “Impacts santaires du développement des larges réserves d’eau, barrages et irrigation”, in Écologie de la santé et biodiversité : cours. Bruxelles: De Boeck (Licence Master Doctorat. Biologie), pp. 116–125.   edoc
Kirchhofer, C., Keiser, J. and Huwyler, J. (2010) “Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate”, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. Elsevier, Vol. 878, H. 28, pp. 2770–2774. doi: 10.1016/j.jchromb.2010.08.020.   edoc
Utzinger, J., Keiser, J. and Albonico, M. (2010) “This wormy world : here and there and everywhere”, Parassitologia : organo ufficiale della Società Italiana di Parassitologia. Lombardo, Vol. 52, pp. 47–50.   edoc
Saric, J., Li, J. V., Utzinger, J., Wang, Y., Keiser, J., Dirnhofer, S., Beckonert, O., Sharabiani, M. T. A., Fonville, J. M., Nicholson, J. K. and Holmes, E. (2010) “Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain”, Molecular systems biology. EMBO, Vol. 6 , 396.   edoc
Duthaler, U., Rinaldi, L., Maurelli, M. P., Vargas, M., Utzinger, J., Cringoli, G. and Keiser, J. (2010) “Fasciola hepatica: comparison of the sedimentation and FLOTAC techniques for the detection and quantification of faecal egg counts in rats”, Experimental parasitology : EP. Academic Press, Vol. 126, H. 2, pp. 161–166.   edoc
Zhao, Q., Vargas, M., Dong, Y., Zhou, L., Wang, X., Sriraghavan, K., Keiser, J. and Vennerstrom, J. L. (2010) “Structure-activity relationship of an ozonide carboxylic acid (OZ78) against Fasciola hepatica”, Journal of medicinal chemistry. American Chemical Society, 53(10), pp. 4223–4233. doi: 10.1021/jm100226t .   edoc | Open Access
Keiser, J. and Vargas, M. (2010) “Effect of artemether, artesunate, OZ78, praziquantel, and tribendimidine alone or in combination chemotherapy on the tegument of Clonorchis sinensis”, Parasitology international. Elsevier, Vol. 59, H. 3, pp. 472–476.   edoc
Manneck, T., Haggenmüller, Y. and Keiser, J. (2010) “Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni”, Parasitology. Cambridge University Press, Vol. 137, H. 1, pp. 85–98.   edoc
Wang, Y., Li, J. V., Saric, J., Keiser, J., Wu, J., Utzinger, J. and Holmes, E. (2010) “Advances in metabolic profiling of experimental nematode and trematode infections”, Advances in parasitology. Elsevier, Vol. 73, pp. 373–404.   edoc
Duthaler, U., Smith, T. A. and Keiser, J. (2010) “In vivo and in vitro sensitivity of Fasciola hepatica to combinations of triclabendazole and artesunate, artemether or OZ78”, Antimicrobial agents and chemotherapy : AAC. American Society for Microbiology, Vol. 54, H. 11, pp. 4596–4604.   edoc
Rufener, L., Keiser, J., Kaminsky, R., Mäser, P. and Nilsson, D. (2010) “Phylogenomics of ligand-gated ion channels predicts monepantel effect”, PLoS Pathogens. Public Library of Science, Vol. 6, H. 9 , e1001091.   edoc
Keiser, J., Vargas, M. and Vennerstrom, J. L. (2010) “Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice”, The journal of antimicrobial chemotherapy. Academic Press, Vol. 65, H. 9, pp. 1991–1995.   edoc
Dong, Y., Chollet, J., Vargas, M., Mansour, N. R., Bickle, Q., Alnouti, Y., Huang, J., Keiser, J. and Vennerstrom, J. L. (2010) “Praziquantel analogs with activity against juvenile Schistosoma mansoni”, Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines. Pergamon, Vol. 20, H. 8, pp. 2481–2484.   edoc
Keiser, J., Vargas, M. and Doenhoff, M. J. (2010) “Activity of artemether and mefloquine against juvenile and adult Schistosoma mansoni in athymic and immunocompetent NMRI mice”, American Journal of Tropical Medicine and Hygiene. Williams and Wilkins, Vol. 82, H. 1, pp. 112–114.   edoc
Keiser, J., Veneziano, V., Rinaldi, L., Mezzino, L., Duthaler, U. and Cringoli, G. (2010) “Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep”, Research in Veterinary Science. British Veterinary Association, Vol. 88, H. 1, pp. 107–110.   edoc
Kirchhofer, C., Keiser, J. and Huwyler, J. (2010) “Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate”, Journal of chromatography B. Elsevier, Vol. 878, H. 28, pp. 2770–2774.   edoc
Keiser, J., Kirchhofer, C., Haschke, M., Huwyler, J., Dong, Y., Vennerstrom, J. L., Vanhoff, K., Kaminsky, R. and Malikides, N. (2010) “Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep”, Veterinary parasitology. Elsevier, Vol. 173, H. 3-4, pp. 228–235.   edoc
Xiao, S. H., Keiser, J., Chen, M. G., Tanner, M. and Utzinger, J. (2010) “Research and development of antischistosomal drugs in the People’s Republic of China a 60-year review”, Advances in parasitology. Elsevier, Vol. 73, pp. 231–295.   edoc
Utzinger, J., Tanner, M. and Keiser, J. (2010) “ACTs for schistosomiasis: do they act?”, The Lancet infectious diseases. Elsevier, pp. 579–581.   edoc
Keiser, J., N’Guessan N. A., Adoubryn, K. D., Silué, K. D., Vounatsou, P., Hatz, C., Utzinger, J. and N’Goran E. K. (2010) “Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against Schistosoma haematobium: randomized, exploratory open-label trial”, Clinical Infectious Diseases. Oxford University Press, Vol. 50, H. 9, pp. 1205–1213.   edoc
Keiser, J. (2009) “Vascular pharmacology : opportunities for intervention”, Clinical pharmacology and therapeutics. Mosby, Vol. 86, H. 2, pp. 124–126. doi: 10.1038/clpt.2009.111.   edoc
Kim, T. I., Yoo, W. G., Li, S., Hong, S. T., Keiser, J. and Hong, S. J. (2009) “Efficacy of artesunate and artemether against Clonorchis sinensis in rabbits”, Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie. Springer-Verlag, Vol. 106, pp. 153–160.   edoc
Koudou, B. G., Tano, Y., Keiser, J., Vounatsou, P., Girardin, O., Klero, K., Koné, M., N’goran, E. K., Cissé, G., Tanner, M. and Utzinger, J. (2009) “Effect of agricultural activities on prevalence rates, and clinical and presumptive malaria episodes in central Côte d’Ivoire”, Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin = revue des sciences tropicales et de médecine tropicale = review of tropical science and tropical medicine. Elsevier Science Publ, 111(3), pp. 268–274. doi: 10.1016/j.actatropica.2009.05.006.   edoc
Tchicaya, E. S., Koudou, B. G., Keiser, J., Adja, A. M., Cissé, G., Tanner, M., Tano, Y. and Utzinger, J. (2009) “Effect of repeated application of microbial larvicides on malaria transmission in central Côte d’Ivoire”, Journal of the American mosquito control association : mosquito news. The American Mosquito Control Association, Vol. 25, H. 3, pp. 382–385.   edoc
Keiser, J., Chollet, J., Xiao, S. H., Mei, J. Y., Jiao, P. Y., Utzinger, J. and Tanner, M. (2009) “Mefloquine - an aminoalcohol with promising antischistosomal properties in mice”, PLoS neglected tropical diseases. Library of Science, Vol. 3, H. 1 , e350.   edoc
Xiao, S.-H., Chollet, J., Utzinger, J., Mei, J.-Y., Jiao, P.-Y., Keiser, J. and Tanner, M. (2009) “Effect of single-dose oral mefloquine on the morphology of adult Schistosoma japonicum in mice”, Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie. Springer-Verlag, Vol. 105, H. 3, pp. 853–861.   edoc
Zhang, C.-W., Xiao, S.-H., Utzinger, J., Chollet, J., Keiser, J. and Tanner, M. (2009) “Histopathological changes in adult Schistosoma japonicum harbored in mice treated with a single dose of mefloquine”, Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie. Springer-Verlag, Vol. 104, H. 6, pp. 1407–1416.   edoc
Xiao, S.-H., Keiser, J., Xue, J., Tanner, M., Morson, G. and Utzinger, J. (2009) “Effect of single-dose oral artemether and tribendimidine on the tegument of adult Clonorchis sinensis in rats”, Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie. Springer-Verlag, Vol. 104, H. 3, pp. 533–541.   edoc
Keiser, J., Xiao, S.-H., Smith, T. A. and Utzinger, J. (2009) “Combination chemotherapy against Clonorchis sinensis : experiments with artemether, artesunate, OZ78, praziquantel, and tribendimidine in the rat model”, Antimicrobial agents and chemotherapy. American Society for Microbiology, Vol. 53, H. 9, pp. 3770–3776.   edoc
Keiser, J. and Utzinger, J. (2009) “Food-borne trematodiases”, Clinical microbiology reviews. American Society for Microbiolgy, Vol. 22, pp. 466–483.   edoc
Erlanger, T. E., Weiss, S., Keiser, J., Utzinger, J. and Wiedenmayer, K. (2009) “Past, present, and future of Japanese encephalitis”, Emerging Infectious Diseases. National Center for Infectious Diseases, Vol. 15, no. 1 , 7 S.   edoc
Saric, J., Li, J. V., Wang, Y., Keiser, J., Veselkov, K. A., Dirnhofer, S., Yap, I. K., Nicholson, J. K., Holmes, E. and Utzinger, J. (2009) “Panorganismal metabolic response modelling of an experimental Echinostoma caproni infection in the mouse”, Journal of Proteome Research. American Chemical Society, Vol. 8, H. 8, pp. 3899–3911.   edoc
Li, J. V., Holmes, E., Saric, J., Keiser, J., Dirnhofer, S., Utzinger, J. and Wang, Y. (2009) “Metabolic profiling of a Schistosoma mansoni infection in mouse tissues using magic angle spinning-nuclear magnetic resonance spectroscopy”, International journal for parasitology. Elsevier, Vol. 39, pp. 547–558.   edoc
Keiser, J., Gruyer, M.-S., Perrottet, N., Zanolari, B., Mercier, T. and Decosterd, L. (2009) “Pharmacokinetic parameters of artesunate and dihydroartemisinin in rats infected with Fasciola hepatica”, Journal of Antimicrobial Chemotherapy. Academic Press, Vol. 63, H. 3, pp. 543–549.   edoc
Halferty, L., O’Neill, J. F., Brennan, G. P., Keiser, J. and Fairweather, I. (2009) “Electron microscopical study to assess the in vitro effects of the synthetic trioxolane OZ78 against the liver fluke, Fasciola hepatica”, Parasitology. Cambridge University Press, Vol. 136, H. 11, pp. 1325–1337.   edoc
O’Neill J. F., Johnston, R. C., Halferty, L., Brennan, G. P., Keiser, J. and Fairweather, I. (2009) “Adult triclabendazole-resistant Fasciola hepatica: morphological changes in the tegument and gut following in vivo treatment with artemether in the rat model”, Journal of Helminthology. Cambridge University Press, Vol. 83, H. 2, pp. 151–163.   edoc
Lovis, L., Mak, T. K., Phongluxa, K., Soukhathammavong, P., Sayasone, S., Akkhavong, K., Odermatt, P., Keiser, J. and Felger, I. (2009) “PCR diagnosis of Opisthorchis viverrini and Haplorchis taichui infections in a Lao community in an area of endemicity and comparison of diagnostic methods for parasitological field surveys”, Journal of Clinical Microbiology. Soc, Vol. 47, H. 5, pp. 1517–1523.   edoc
Hodel, E. M., Zanolari, B., Mercier, T., Biollaz, J., Keiser, J., Olliaro, P., Genton, B. and Decosterd, L. A. (2009) “A single LC-tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma”, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. Elsevier, Vol. 877, H. 10, pp. 867–886.   edoc
Keiser, J., Odermatt, P. and Tesana, S. (2009) “Dose-response relationships and tegumental surface alterations in Opisthorchis viverrini following treatment with mefloquine in vivo and in vitro”, Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie. Springer-Verlag, Vol. 105, H. 1, pp. 261–266.   edoc
Caffrey, C. R., Williams, D. L., Todd, M. J., Nelson, D. L., Keiser, J., Utzinger, J. and Selzer, P. M. (2009) “Chemotherapeutic development strategies for schistosomiasis”, in Antiparasitic and Antibacterial drug discovery. Weinheim: Wiley-Blackwell (Drug discovery in infectious diseases), pp. 301–321.   edoc
Erlanger, T. E., Keiser, J. and Utzinger, J. (2008) “Effect of dengue vector control interventions on entomological parameters in developing countries : a systematic review and meta-analysis”, Medical and veterinary entomology. Blackwell, Vol. 22, H. 3, pp. 203–221. doi: 10.1111/j.1365-2915.2008.00740.x.   edoc
Keiser, J. and Utzinger, J. (2008) “Efficacy of current drugs against soil-transmitted helminth infections : systematic review and meta-analysis”, JAMA : the journal of the American Medical Association. American Medical Association, Vol. 299, H. 16, pp. 1937–1948. doi: 10.1001/jama.299.16.1937.   edoc
Keiser, J., Thiemann, K., Endriss, Y. and Utzinger, J. (2008) “Strongyloides ratti : In Vitro and In Vivo Activity of Tribendimidine”, PLoS neglected tropical diseases. Public Library of Science, Vol. 2, H. 1 , e136.   edoc
Xue, J., Utzinger, J., Zhang, Y. N., Tanner, M., Keiser, J. and Xiao, S. H. (2008) “Artemether and tribendimidine lack activity in experimental treatment of Paragonimus westermani in the dog”, Parasitology research. Springer-Verlag, Vol. 102, H. 3, pp. 537–540.   edoc
Keiser, J., Rinaldi, L., Veneziano, V., Mezzino, L., Tanner, M., Utzinger, J. and Cringoli, G. (2008) “Efficacy and safety of artemether against a natural Fasciola hepatica infection in sheep”, Parasitology research. Springer-Verlag, Vol. 103, H. 3, pp. 517–522. doi: 10.1007/s00436-008-0998-0.   edoc
Spicher, M., Roethlisberger, C., Lany, C., Stadelmann, B., Keiser, J., Ortega-Mora, L. M., Gottstein, B. and Hemphill, A. (2008) “In vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives”, Antimicrobial agents and chemotherapy. American Society for Microbiology, Vol. 52, H. 9, pp. 3447–3450.   edoc
Saric, J., Li, J. V., Wang, Y., Keiser, J., Bundy, J. G., Holmes, E. and Utzinger, J. (2008) “Metabolic Profiling of an Echinostoma caproni Infection in the Mouse for Biomarker Discovery”, PLoS Neglected Tropical Diseases. Public Library of Science, Vol. 2, H. 7 , e254.   edoc
Keiser, J., Utzinger, J., Xiao, S. H., Odermatt, P. and Tesana, S. (2008) “Opisthorchis viverrini : efficacy and tegumental alterations following administration of tribendimidine in vivo and in vitro”, Parasitology research. Springer-Verlag, Vol. 102, pp. 771–776.   edoc
Xiao, S. H., Jian, X., Tanner, M., Yong-Nian, Z., Keiser, J., Utzinger, J. and Hui-Qiang, Q. (2008) “Artemether, artesunate, praziquantel and tribendimidine administered singly at different dosages against Clonorchis sinensis : a comparative in vivo study”, Acta tropica. Elsevier Science Publ, 106(1), pp. 54–59. doi: 10.1016/j.actatropica.2008.01.003.   edoc
Keiser, J. and Morson, G. (2008) “Fasciola hepatica: Surface tegumental responses to in vitro and in vivo treatment with the experimental fasciolicide OZ78”, Experimental parasitology : EP. Academic Press, Vol. 119, pp. 87–93.   edoc
Keiser, J. and Morson, G. (2008) “Fasciola hepatica: tegumental alterations in adult flukes following in vitro and in vivo administration of artesunate and artemether”, Experimental parasitology : EP. Academic Press, Vol. 118, pp. 228–237.   edoc
Saric, J., Wang, Y., Li, J., Coen, M., Utzinger, J., Marchesi, J. R., Keiser, J., Veselkov, K., Lindon, J. C., Nicholson, J. K. and Holmes, E. (2008) “Species variation in the fecal metabolome gives insight into differential gastrointestinal function”, Journal of Proteome Research. American Chemical Society, Vol. 7, H. 1, pp. 352–360.   edoc
Keiser, J. (1999) Pharmacological investigations on current and new drugs for treatment of human African trypanosomiasis. doi: 10.5451/unibas-002031674.   edoc | Open Access