Publications

Liao, C. and Seebeck, F. P. (2020) “Asymmetric β-Methylation of l- and d-α-Amino Acids by a Self-Contained Enzyme Cascade”, Angewandte Chemie International Edition. Wiley, 59(18), pp. 7184–7187. doi: 10.1002/anie.201916025.   edoc
Maurer, A. and Seebeck, F. P. (2020) “Reexamination of the Ergothioneine Biosynthetic Methyltransferase EgtD from Mycobacterium tuberculosis as a Protein Kinase Substrate”, ChemBioChem. Wiley, 21(20), pp. 2908–2911. doi: 10.1002/cbic.202000232.   edoc
Flückger, S., Igareta, N. V. and Seebeck, F. P. (2020) “Convergent Evolution of Fungal Cysteine Dioxygenases”, ChemBioChem. Wiley, 21(21), pp. 3082–3086. doi: 10.1002/cbic.202000317.   edoc
Milito, A., Castellano, I., Burn, R., Seebeck, F. P., Brunet, C. and Palumbo, A. (2020) “First evidence of ovothiol biosynthesis in marine diatoms”, Free radical biology and medicine. Elsevier, 152, pp. 680–688. doi: 10.1016/j.freeradbiomed.2020.01.010.   edoc
Stampfli, A. R. and Seebeck, F. P. (2020) “The catalytic mechanism of sulfoxide synthases”, Current Opinion in Chemical Biology. Elsevier, 59, pp. 111–118. doi: 10.1016/j.cbpa.2020.06.007.   edoc
Stampfli, A. R., Blankenfeldt, W. and Seebeck, F. P. (2020) “Structural basis of ergothioneine biosynthesis”, Current Opinion in Structural Biology. Elsevier, 65, pp. 1–8. doi: 10.1016/j.sbi.2020.04.002.   edoc
Goncharenko, K. V., Flückiger, S., Liao, C., Lim, D., Stampfli, A. R. and Seebeck, F. P. (2020) “Selenocysteine as a Substrate, an Inhibitor and a Mechanistic Probe for Bacterial and Fungal Iron-Dependent Sulfoxide Synthases”, Chemistry - A European Journal. Wiley, 26(6), pp. 1328–1334. doi: 10.1002/chem.201903898.   edoc
Lim, D., Wen, X. and Seebeck, F. P. (2020) “Selenoimidazolium Salts as Supramolecular Reagents for Protein Alkylation”, Chembiochem : a European journal of chemical biology. Wiley, 21(24), pp. 3515–3520. doi: 10.1002/cbic.202000557.   edoc
Liao, C. and Seebeck, F. P. (2019) “S-adenosylhomocysteine as a methyl transfer catalyst in biocatalytic methylation reactions”, Nature Catalysis . Springer Nature , 2(8), pp. 696–701. doi: 10.1038/s41929-019-0300-0.   edoc | Open Access
Leisinger, F., Burn, R., Meury, M., Lukat, P. and Seebeck, F. P. (2019) “Structural and Mechanistic Basis for Anaerobic Ergothioneine Biosynthesis”, Journal of the American Chemical Society. American Chemical Society, 141 (17), pp. 6906–6914. doi: 10.1021/jacs.8b12596.   edoc | Open Access
Maurer, A., Leisinger, F., Lim, D. and Seebeck, F. P. (2019) “Structure and Mechanism of Ergothionase from Treponema denticola”, Chemistry - A European Journal. Wiley, 25(44), pp. 10298–10303. doi: 10.1002/chem.201901866.   edoc | Open Access
Miarzlou, D. A., Leisinger, F., Joss, D., Häussinger, D. and Seebeck, F. P. (2019) “Structure of formylglycine-generating enzyme in complex with copper and a substrate reveals an acidic pocket for binding and activation of molecular oxygen”, Chemical Science. Royal Society of Chemistry, 10(29), pp. 7049–7058. doi: 10.1039/c9sc01723b.   edoc | Open Access
Lim, D., Gründemann, D. and Seebeck, F. P. (2019) “Total Synthesis and Functional Characterization of Selenoneine”, Angewandte Chemie International Edition. Wiley, 58(42), pp. 15026–15030. doi: 10.1002/anie.201908967.   edoc | Open Access
Liao, C. and Seebeck, F. P. (2019) “In vitro reconstitution of bacterial DMSP biosynthesis”, Angew. Chemie Int. Ed, 35, pp. 3553–3556.   edoc
Stampfli, A. R., Goncharenko, K. V., Meury, M., Dubey, B. N., Schirmer, T. and Seebeck, F. P. (2019) “An Alternative Active Site Architecture for O2 Activation in the Ergothioneine Biosynthetic EgtB from Chloracidobacterium thermophilum”, Journal of American Chemical Society. American Chemical Society, 141(13), pp. 5275–5285. doi: 10.1021/jacs.8b13023.   edoc | Open Access
Misson, L., Burn, R., Vit, A., Hildesheim, J., Beliaeva, M. A., Blankenfeldt, W. and Seebeck, F. P. (2018) “Inhibition and Regulation of the Ergothioneine Biosynthetic Methyltransferase EgtD”, ACS Chemical Biology. American Chemical Society, 13(5), pp. 1333–1342. doi: 10.1021/acschembio.8b00127.   edoc | Open Access
Castellano, I. and Seebeck, F. P. (2018) “On ovothiol biosynthesis and biological roles: from life in the ocean to therapeutic potential”, Natural Product Reports. The Royal Society of Chemistry, 35(12), pp. 1241–1250. doi: 10.1039/c8np00045j.   edoc | Open Access
Gamage, A. M., Liao, C., Cheah, I. K., Chen, Y., Lim, D. R. X., Ku, J. W. K., Chee, R. S. L., Gengenbacher, M., Seebeck, F. P., Halliwell, B. and Gan, Y.-H. (2018) “The proteobacterial species Burkholderia pseudomallei produces ergothioneine, which enhances virulence in mammalian infection”, FASEB Journal. Federation of American Society of Experimental Biology , 32(12), pp. 6395–6409. doi: 10.1096/fj.201800716.   edoc
Knop, M., Dang, T. Q., Jeschke, G. and Seebeck, F. P. (2017) “Copper is a Cofactor of the Formylglycine-Generating Enzyme”, ChemBioChem. Wiley, 18(2), pp. 161–165. doi: 10.1002/cbic.201600359.   edoc | Open Access
Meury, M., Knop, M. and Seebeck, F. P. (2017) “Structural Basis for Copper-Oxygen Mediated C-H Bond Activation by the Formylglycine-Generating Enzyme”, Angewandte Chemie International Edition. Wiley, 56(28), pp. 8115–8119. doi: 10.1002/anie.201702901.   edoc | Open Access
Knop, M., Lemnaru, R. and Seebeck, F. P. (2017) “Mutation of Conserved Residues Increases in Vitro Activity of the Formylglycine-Generating Enzyme”, ChemBioChem. Wiley, 18(17), pp. 1755–1761. doi: 10.1002/cbic.201700174.   edoc
Faponle, A. S., Seebeck, F. P. and de Visser, S. P. (2017) “Sulfoxide Synthase versus Cysteine Dioxygenase Reactivity in a Nonheme Iron Enzyme”, Journal of the American Chemical Society. American Chemical Society, 139(27), pp. 9259–9270. doi: 10.1021/jacs.7b04251.   edoc | Open Access
Burn, R., Misson, L., Meury, M. and Seebeck, F. P. (2017) “Anaerobic Origin of Ergothioneine”, Angewandte Chemie International Edition. Wiley, 56(41), pp. 12508–12511. doi: 10.1002/anie.201705932.   edoc
Liao, C. and Seebeck, F. P. (2017) “Convergent Evolution of Ergothioneine Biosynthesis in Cyanobacteria”, ChemBioChem. Wiley, 18(21), pp. 2115–2118. doi: 10.1002/cbic.201700354.   edoc
Goncharenko, K. and Seebeck, F. P. (2016) “Conversion of a non-heme iron-dependent sulfoxide synthase into a thiol dioxygenase by a single point mutation”, Chemical Communications . Royal Society of Chemistry, 52(9), pp. 1945–1948. doi: 10.1039/c5cc07772a.   edoc | Open Access
Vit, A., Mashabela, G., Blankenfeldt, W. and Seebeck, F. P. (2015) “Structure of the Ergothioneine-Biosynthesis Amidohydrolase EgtC”, ChemBioChem. Wiley, 16(10), pp. 1490–1496. doi: 10.1002/cbic.201500168.   edoc | Open Access
Knop, M., Engi, P., Lemnaru, R. and Seebeck, F. P. (2015) “In Vitro Reconstitution of Formylglycine-Generating Enzymes Requires Copper(I)”, ChemBioChem. Wiley, 16(15), pp. 2147–2150. doi: 10.1002/cbic.201500322.   edoc | Open Access
Goncharenko, K. V., Vit, A., Blankenfeldt, W. and Seebeck, F. P. (2015) “Structure of the Sulfoxide Synthase EgtB from the Ergothioneine Biosynthetic Pathway”, Angewandte Chemie International Edition. Wiley, 54(9), pp. 2821–2824. doi: 10.1002/anie.201410045.   edoc | Open Access
Vit, A., Misson, L., Blankenfeldt, W. and Seebeck, F. P. (2015) “Ergothioneine Biosynthetic Methyltransferase EgtD Reveals the Structural Basis of Aromatic Amino Acid Betaine Biosynthesis”, ChemBioChem. Wiley, 16(1), pp. 119–125. doi: 10.1002/cbic.201402522.   edoc
Vit, A., Misson, L., Blankenfeldt, W. and Seebeck, F. (2014) “Crystallization and preliminary X-ray analysis of the ergothioneine-biosynthetic methyltransferase EgtD”, Acta Crystallographica Section F: Structural Biology and Crystallization Communications. International Union of Crystallography , 70(5), pp. 676–680. doi: 10.1107/S2053230X1400805X.   edoc | Open Access
Seebeck, F. (2013) “Thiohistidine biosynthesis”, Chimia. Schweizerische Chemische Gesellschaft, 67(5), pp. 333–336. doi: 10.2533/chimia.2013.333.   edoc | Open Access
Mashabela, G. and Florian, S. (2013) “Substrate specificity of an oxygen dependent sulfoxide synthase in ovothiol biosynthesis”, Chemical Communications. Royal Society of Chemistry, 49(70), pp. 7714–7716. doi: 10.1039/c3cc42594k.   edoc | Open Access
Amrein, B., Schmid, M., Collet, G., Cuniasse, P., Gilardoni, F., Seebeck, F. P. and Ward, T. R. (2012) “Identification of two-histidines one-carboxylate binding motifs in proteins amenable to facial coordination to metals”, Metallomics. Royal Society of Chemistry, 4(4), pp. 379–388. doi: 10.1039/C2MT20010D.   edoc
Hofmann, F., Szostak, J. W. and Seebeck, F. P. (2012) “In vitro selection of functional lantipeptides”, Journal of the American Chemical Society. American Chemical Society, 134(19), pp. 8038–8041. doi: 10.1021/ja302082d.   edoc