Publications

Silva-Vargas, V. and Doetsch, F. (2020) “Exploring the source of human brain fluids”, Science (New York, N.Y.), 369(6500), pp. 143–144. doi: 10.1126/science.abd0269.   
Mizrak, D., Levitin, H. M., Delgado, A. C., Crotet, V., Yuan, J., Chaker, Z., Silva-Vargas, V., Sims, P. A. and Doetsch, F. (2019) “Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages”, Cell reports. Cell Press, 26(2), pp. 394–406.e5. doi: 10.1016/j.celrep.2018.12.044.   edoc
Crouch, E. E. and Doetsch, F. (2018) “FACS isolation of endothelial cells and pericytes from mouse brain microregions”, Nature protocols, 13(4), pp. 738–751. doi: 10.1038/nprot.2017.158.   edoc
Ghersi-Egea, J.-F., Strazielle, N., Catala, M., Silva-Vargas, V., Doetsch, F. and Engelhardt, B. (2018) “Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease”, Acta neuropathologica, 135(3), pp. 337–361. doi: 10.1007/s00401-018-1807-1.   edoc
Silva-Vargas, V., Delgado, A. C. and Doetsch, F. (2018) “Symmetric Stem Cell Division at the Heart of Adult Neurogenesis”, Neuron, 98(2), pp. 246–248. doi: 10.1016/j.neuron.2018.04.005.   edoc
Tome-Garcia, J., Doetsch, F. and Tsankova, N. M. (2017) “FACS-based Isolation of Neural and Glioma Stem Cell Populations from Fresh Human Tissues Utilizing EGF Ligand”, Bio-protocol, 7(24), p. 23. doi: 10.21769/BioProtoc.2659.   edoc | Open Access
Tome-Garcia, J., Tejero, R., Nudelman, G., Yong, R. L., Sebra, R., Wang, H., Fowkes, M., Magid, M., Walsh, M., Silva-Vargas, V., Zaslavsky, E., Friedel, R. H., Doetsch, F. and Tsankova, N. M. (2017) “Prospective Isolation and Comparison of Human Germinal Matrix and Glioblastoma EGFR(+) Populations with Stem Cell Properties”, Stem Cell Reports. Elsevier, 8(5), pp. 1421–1429. doi: 10.1016/j.stemcr.2017.03.019.   edoc
Paul, A., Chaker, Z. and Doetsch, F. (2017) “Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis”, Science. American Association for the Advancement of Science, 356(6345), pp. 1383–1386. doi: 10.1126/science.aal3839.   edoc
Silva-Vargas, V., Maldonado-Soto, A. R., Mizrak, D., Codega, P. and Doetsch, F. (2016) “Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells”, Cell stem cell. Cell Press, 19(5), pp. 643–652. doi: 10.1016/j.stem.2016.06.013.   edoc
Chaker, Z., Codega, P. and Doetsch, F. (2016) “A mosaic world: puzzles revealed by adult neural stem cell heterogeneity”, WIREs Developmental Biology. Wiley-Blackwell, pp. 640–658. doi: 10.1002/wdev.248.   edoc
Erfani, P., Tome-Garcia, J., Canoll, P., Doetsch, F. and Tsankova, N. M. (2015) “EGFR promoter exhibits dynamic histone modifications and binding of ASH2L and P300 in human germinal matrix and gliomas”, Epigenetics. Landes Bioscience, Vol. 10, Issue 6, pp. 496–507. doi: 10.1080/15592294.2015.1042645.   edoc
Crouch, E. E., Liu, C., Silva-Vargas, V. and Doetsch, F. (2015) “Regional and Stage-Specific Effects of Prospectively Purified Vascular Cells on the Adult V-SVZ Neural Stem Cell Lineage”, Journal of Neuroscience. Society for Neuroscience, 35(11), pp. 4528–4539. doi: 10.1523/JNEUROSCI.1188-14.2015.   edoc | Open Access
Maldonado-Soto, A. R., Oakley, D. H., Wichterle, H., Stein, J., Doetsch, F. K. and Henderson, C. E. (2014) “Stem Cells in the Nervous System”, American Journal of Physical Medicine and Rehabilitation. Lippincott Williams & Wilkins, 93(11-S3), pp. 132–144. doi: 10.1097/PHM.0000000000000111.   edoc | Open Access
Codega, P., Silva-Vargas, V., Paul, A., Maldonado-Soto, A. R., Deleo, A. M., Pastrana, E. and Doetsch, F. (2014) “Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche”, Neuron. Elsevier, 82(3), pp. 545–559. doi: 10.1016/j.neuron.2014.02.039.   edoc
Silva-Vargas, V. and Doetsch, F. (2014) “A new twist for neurotrophins : endothelial-derived NT-3 mediates adult neural stem cell quiescence”, Neuron. Cell Press, pp. 507–509. doi: 10.1016/j.neuron.2014.07.029.   edoc
Silva-Vargas, V., Crouch, E. E. and Doetsch, F. (2013) “Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging”, Current Opinion in Neurobiology. Elsevier, 23(6), pp. 935–942. doi: 10.1016/j.conb.2013.09.004.   edoc
Pastrana, E., Silva-Vargas, V. and Doetsch, F. (2011) “Eyes wide open: a critical review of sphere-formation as an assay for stem cells”, Cell Stem Cell. Cell Press, 8(5), pp. 486–498.   edoc
Carro, M. S., Lim, W. K., Alvarez, M. J., Bollo, R. J., Zhao, X., Snyder, E. Y., Sulman, E. P., Anne, S. L., Doetsch, F., Colman, H., Lasorella, A., Aldape, K., Califano, A. and Iavarone, A. (2010) “The transcriptional network for mesenchymal transformation of brain tumours”, Nature. Macmillan, 463(7279), pp. 318–325. doi: 10.1038/nature08712.   edoc
Mirzadeh, Z., Doetsch, F., Sawamoto, K., Wichterle, H. and Alvarez-Buylla, A. (2010) “The subventricular zone en-face: wholemount staining and ependymal flow”, Journal of Visualized Experiments. JoVE, (39). doi: 10.3791/1938.   edoc
Kim, Y., Wang, W.-Z., Comte, I., Pastrana, E., Tran, P. B., Brown, J., Miller, R. J., Doetsch, F., Molnár, Z. and Szele, F. G. (2010) “Dopamine stimulation of postnatal murine subventricular zone neurogenesis via the D3 receptor”, Journal of Neurochemistry. Wiley-Blackwell, 114(3), pp. 750–760. doi: 10.1111/j.1471-4159.2010.06799.x.   edoc
Cheng, L.-C., Pastrana, E., Tavazoie, M. and Doetsch, F. (2009) “miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche”, Nature Neuroscience. Nature America, 12(4), pp. 399–408. doi: 10.1038/nn.2294.   edoc
Pastrana, E., Cheng, L.-C. and Doetsch, F. (2009) “Simultaneous prospective purification of adult subventricular zone neural stem cells and their progeny”, Proceedings of the National Academy of Sciences. National Academy of Sciences, 106(15), pp. 6387–6392. doi: 10.1073/pnas.0810407106.   edoc
Riquelme, P. A., Drapeau, E. and Doetsch, F. (2008) “Brain micro-ecologies: neural stem cell niches in the adult mammalian brain”, Philosophical Transactions B: Biological Sciences. The Royal Society, 363(1489), pp. 123–137. doi: 10.1098/rstb.2006.2016.   edoc
Tavazoie, M., Van der Veken, L., Silva-Vargas, V., Louissaint, M., Colonna, L., Zaidi, B., Garcia-Verdugo, J. M. and Doetsch, F. (2008) “A specialized vascular niche for adult neural stem cells”, Cell Stem Cell. Cell Press, 3(3), pp. 279–288. doi: 10.1016/j.stem.2008.07.025.   edoc
Galan-Caridad, J. M., Harel, S., Arenzana, T. L., Hou, Z. E., Doetsch, F. K., Mirny, L. A. and Reizis, B. (2007) “Zfx controls the self-renewal of embryonic and hematopoietic stem cells”, Cell. Cell Press, 129(2), pp. 345–357. doi: 10.1016/j.cell.2007.03.014.   edoc
Doetsch, F. and Hen, R. (2005) “Young and excitable: the function of new neurons in the adult mammalian brain”, Current Opinion in Neurobiology. Elsevier, 15(1), pp. 121–128. doi: 10.1016/j.conb.2005.01.018.   edoc
Cheng, L.-C., Tavazoie, M. and Doetsch, F. (2005) “Stem cells: from epigenetics to microRNAs”, Neuron. Elsevier, 46(3), pp. 363–367. doi: 10.1016/j.neuron.2005.04.027.   edoc
Doetsch, F. (2003) “A niche for adult neural stem cells”, Current Opinion in Genetics & Development. Elsevier, 13(5), pp. 543–550. doi: 10.1016/j.gde.2003.08.012.   edoc
Doetsch, F. (2003) “The glial identity of neural stem cells”, Nature Neuroscience. Nature America, 6(11), pp. 1127–1134. doi: 10.1038/nn1144.   edoc
Gritti, A., Bonfanti, L., Doetsch, F., Caille, I., Alvarez-Buylla, A., Lim, D. A., Galli, R., Verdugo, J. M. G., Herrera, D. G. and Vescovi, A. L. (2002) “Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents”, Journal of Neuroscience. Society for Neuroscience, 22(2), pp. 437–445.   edoc
Doetsch, F., Verdugo, J. M.-G., Caille, I., Alvarez-Buylla, A., Chao, M. V. and Casaccia-Bonnefil, P. (2002) “Lack of the cell-cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesis”, Journal of Neuroscience. Society for Neuroscience, 22(6), pp. 2255–2264.   edoc
Doetsch, F. (2002) “Genetics of childhood disorders: XXXVIII. Stem cell research, part 2: reconstructing the brain”, Journal of the American Academy of Child and Adolescent Psychiatry. Lippincott Williams & Wilkins, 41(5), pp. 622–624. doi: 10.1097/00004583-200205000-00021.   edoc
Alvarez-Buylla, A., Seri, B. and Doetsch, F. (2002) “Identification of neural stem cells in the adult vertebrate brain”, Brain Research Bulletin. Elsevier, 57(6), pp. 751–758. doi: 10.1016/S0361-9230(01)00770-5.   edoc
Doetsch, F., Petreanu, L., Caille, I., Garcia-Verdugo, J. M. and Alvarez-Buylla, A. (2002) “EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells”, Neuron. Elsevier, 36(6), pp. 1021–1034. doi: 10.1016/S0896-6273(02)01133-9.   edoc
Doetsch, F. and Scharff, C. (2001) “Challenges for brain repair: insights from adult neurogenesis in birds and mammals”, Brain, Behavior and Evolution. Karger, 58(5), pp. 306–322. doi: 10.1159/000057572.   edoc | Open Access
Conover, J. C., Doetsch, F., Garcia-Verdugo, J. M., Gale, N. W., Yancopoulos, G. D. and Alvarez-Buylla, A. (2000) “Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone”, Nature Neuroscience. Nature America, 3(11), pp. 1091–1097. doi: 10.1038/80606.   edoc
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M. and Alvarez-Buylla, A. (1999) “Subventricular zone astrocytes are neural stem cells in the adult mammalian brain”, Cell. Cell Press, 97(6), pp. 703–716. doi: 10.1016/S0092-8674(00)80783-7.   edoc
Doetsch, F., García-Verdugo, J. M. and Alvarez-Buylla, A. (1999) “Regeneration of a germinal layer in the adult mammalian brain”, Proceedings of the National Academy of Sciences. National Academy of Sciences, 96(20), pp. 11619–11624.   edoc
Kirschenbaum, B., Doetsch, F., Lois, C. and Alvarez-Buylla, A. (1999) “Adult subventricular zone neuronal precursors continue to proliferate and migrate in the absence of the olfactory bulb”, Journal of Neuroscience. Society for Neuroscience, 19(6), pp. 2171–2180. Available at: http://www.jneurosci.org/content/jneuro/19/6/2171.full.pdf.   edoc
García-Verdugo, J. M., Doetsch, F., Wichterle, H., Lim, D. A. and Alvarez-Buylla, A. (1998) “Architecture and cell types of the adult subventricular zone: in search of the stem cells”, Journal of Neurobiology. Wiley, 36(2), pp. 234–248. doi: 10.1002/(SICI)1097-4695(199808)36:2<234::AID-NEU10>3.0.CO;2-E.   edoc
Doetsch, F., García-Verdugo, J. M. and Alvarez-Buylla, A. (1997) “Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain”, Journal of Neuroscience. Society for Neuroscience, 17(13), pp. 5046–5061.   edoc
Doetsch, F. and Alvarez-Buylla, A. (1996) “Network of tangential pathways for neuronal migration in adult mammalian brain”, Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 93(25), pp. 14895–14900.   edoc